جستجوی استاد راهنمای دانشگاهی

Prof. Maria-Elena Torres-Padilla is a prominent academic leading research in epigenetics and stem cell biology. She holds the position of Professor for Stem Cell Biology at Ludwig-Maximilians-University Munich (LMU) and is Director of multiple institutes, including the Institute for Epigenetics and Stem Cells and the Stem Cell Center at Helmholtz Munich. Her work focuses on understanding the epigenetic mechanisms underlying cellular reprogramming, totipotency, and early embryonic development. Education: Maria-Elena earned her undergraduate degree in Biology from the National University of Mexico (UNAM), followed by a PhD in Molecular Biology at the Institut Pasteur in Paris. She completed her postdoctoral training at the Gurdon Institute, University of Cambridge, before establishing her independent research group in 2008. Research Interests: Her lab investigates how chromatin dynamics and epigenetic regulation shape cell fate decisions in early embryos. Key areas include the role of histone modifications, nuclear organization, and transposable elements in maintaining totipotency and driving cellular plasticity. Her work aims to engineer cells for regenerative therapies targeting neurodegenerative diseases and brain injuries. Publications: Recent work highlights discoveries in nuclear architecture, epigenetic pathways, and transposable element regulation during embryogenesis. These studies underscore the importance of chromatin dynamics in developmental processes and therapeutic applications. Awards: She has received prestigious accolades, including the 2025 Leibniz Prize (Germany’s highest scientific honor), membership in the German Academy of Sciences Leopoldina, and recognition by the World Economic Forum as a Young Scientist. Advising & Grants: She mentors a multidisciplinary team of postdocs and doctoral researchers, fostering a diverse and collaborative environment. Her lab’s funding includes ERC grants and initiatives like the LifeTime European Initiative, supporting her vision to bridge basic and translational research. Labs & Teams: The Torres-Padilla Lab at Helmholtz Munich integrates microscopy, genomics, and computational biology to study epigenetic principles in development. Collaborations span disciplines, including the Epigenetics@HelmholtzMunich network, to advance cell-based therapies. Her future work aims to leverage epigenetic insights to create ‘cells à la carte’ for regenerative medicine, emphasizing ethical and societal impacts of scientific innovation.

• Epigenetics
• Stem Cell Biology
• Cell Biology
• +۳ مورد دیگر

Lu Chen is an Assistant Professor at Temple University's Fox Chase Cancer Center, affiliated with the Cancer Epigenetics Institute Research Program specializing in Nuclear Dynamics and Cancer. Their lab focuses on RNA biology mechanisms underlying cancer and aging-related diseases. Key research areas include epigenetic regulation of telomerase, engineering senescence-resistant CAR-T cells, and developing CRISPR-based diagnostics. Education includes a PhD in Biochemistry and Molecular Biology from the University of Kansas Medical Center (2013), postdoctoral training at Stanford University (2013–2019), and a BS from Wuhan University (2006). Honors include the NIGMS-MIRA Award (2023) and Stanford Cancer Institute Fellowship (2018). The lab employs advanced techniques like icSHAPE-seq, CRISPR engineering, and single-molecule imaging. Current projects investigate telomerase regulation, RNA modifications, and translational therapies for degenerative diseases. Collaborations span structural biology, nanotechnology, and clinical oncology. Lab Team: Includes postdocs (Aldana Vistarop, Musinu Zakari), PhD students (Julia Hoopman, Alexander Morris), and undergraduate researchers. Grants: Active NIGMS-MIRA funding supports ongoing studies on RNA processing and cancer immortality. Awards: Recognitions for telomere research and contributions to understanding RNA biology. Labs: Operates at Fox Chase Cancer Center (lab website: luchenlab.org ). Active in mentoring with a focus on training early-career scientists in molecular oncology and RNA technologies.

• RNA Biology
• Cancer Biology
• Epigenetics
• +۵ مورد دیگر

Pier Giuseppe Pelicci is a Full Professor of Pathology at the University of Milan and Scientific Co-Director of the European Institute of Oncology (IEO), Milan. He holds leadership roles including Chairman of the Department of Experimental Oncology at IEO and President of TTFactor Srl, a technology transfer company. His academic career spans positions such as Visiting Professor at New York Medical College and Associate Professor of Oncology at the University of Parma. He earned his MD (Summa cum laude) and PhD in Molecular Biology from the University of Perugia. His research focuses on Cancer Stem Cells , Cell Cycle Control , and Genomics , with contributions to understanding leukemia and breast cancer biology. He has received over 20 prestigious awards, including the 2012 Premio Città di Firenze and the Swiss Bridge Award (2007). Pelicci leads major initiatives like the SEMM Foundation (European School of Molecular Medicine) and serves on scientific advisory boards for institutions worldwide. His work integrates molecular biology, oncology, and translational research to advance cancer treatment strategies.

• Cancer Stem Cells
• Cell Cycle Control
• Genomics
• +۳ مورد دیگر

Eduard C. Hurt is a Full Professor (C4) at Heidelberg University's Faculty of Biosciences, Department of Biochemistry, where he has served since 1995. He directed the Heidelberg University Biochemistry Center (BZH) from 2003–2005. Previously, he was a Group Leader at EMBL Heidelberg (1987–1994) and a postdoc at the University of Basel. His PhD was completed at the University of Regensburg. Hurt's research focuses on fundamental cellular mechanisms including: Nuclear pore complex architecture and nucleocytoplasmic transport Transcription-coupled mRNA export and ribosome biogenesis Chromatin organization, sumoylation, and ubiquitination pathways Nuclear envelope dynamics and membrane biogenesis Analysis of his 15 most recent publications reveals strong emphasis on structural biology of nuclear transport complexes, mechanistic studies of ribosome assembly/export, and mRNA quality control at nuclear pores. His work integrates yeast genetics, biochemistry, and advanced microscopy. Awards & Honors: Gottfried Wilhelm Leibniz Prize (2001) Feldberg Prize (2007) Elected Member: Leopoldina (2003), Academia Europaea (2007) He leads research groups at BZH focusing on nuclear pore complexes and ribosome biogenesis, collaborating internationally on structural biology projects. His lab utilizes biochemical reconstitution, CRISPR-based genomics, and cryo-EM to study macromolecular assemblies.

• Nuclear pore complex
• Nucleocytoplasmic transport
• Ribosome biogenesis
• +۶ مورد دیگر

Anne Dejean is a Professor at INSERM (French National Institute for Health and Medical Research) and Director of the Laboratory of Nuclear Organization and Oncogenesis at the Pasteur Institute since 2003. Her research focuses on molecular and cellular mechanisms underlying cancer development, particularly in hepatocarcinoma and leukemia. Positions: Director at Pasteur Institute/INSERM (2003-present), Professor at INSERM (since 1985) Research Interests: Post-translational modifications (especially SUMOylation), cellular senescence, nuclear organization, retinoic acid receptor signaling, and chromatin dynamics in oncogenesis. Publication Trends: Key themes include SUMO pathway regulation (1998-2010), cancer-related gene expression dysregulation (1986-2006), and chromosomal segregation mechanisms (2005). Recent work explores miR-22/222 roles in liver carcinogenesis. Awards: EMBO member (1995), Chevalier de l'Ordre de la Légion d'Honneur (2007), L'Oréal-UNESCO Award (2010), Inserm Grand Prix (2014), Sjöberg Prize (2018) Her leadership in the Laboratory of Nuclear Organization and Oncogenesis has advanced understanding of nuclear architecture's role in cancer progression.

• Molecular Biology
• Cancer Research
• Post-translational Modifications
• +۳ مورد دیگر

Erin Green is an Associate Professor in the Department of Biological Sciences at the University of Maryland, Baltimore County (UMBC). Her research focuses on epigenetic regulation mediated by post-translational modifications of histones, particularly lysine methylation, and its role in cellular stress responses and chromatin structure. She uses the budding yeast Saccharomyces cerevisiae as a model system, integrating molecular biology, genetics, biochemistry, genomics, and proteomics to explore how these modifications control gene expression and genome integrity. Education : Postdoctoral Fellowship, Stanford University (2013) Ph.D., University of California, Berkeley (2007) B.A., Bryn Mawr College (2000) Research Interests : Regulation of histone lysine methylation in chromatin homeostasis Role of non-histone protein methylation in nuclear signaling pathways Epigenetic mechanisms underlying cellular stress responses and tumorigenesis Grants : Multiple NIH-funded projects, including studies on lysine methylation’s role in proteostasis, stress responses, and telomere maintenance. Notable grants include: “Lysine methylation at chromatin and cellular responses to stress” (2017–2022) “The SMYD lysine methyltransferase Set6 in proteostasis and signaling” (2019–2021, 2023–present) Lab Activities : The Green Lab actively mentors students, with recent advisees including Mandi Lichtenstein, Chase Andre, and Fidelia Asomani. Recent research highlights include publications on noncanonical SET domain proteins, tumor metastasis mechanisms, and telomere maintenance pathways.

• Epigenetics
• Protein Post-Translational Modifications
• Cellular Stress Responses
• +۵ مورد دیگر

Dr. Daniel Sprague, MD, PhD is an Adjunct Assistant Professor in the Department of Biochemistry and Molecular Biology at the Medical University of South Carolina (MUSC). He leads the Sprague Lab, focused on discovering small molecules targeting diseases such as neglected tropical diseases, cancer, and neurotransmission disorders. His work involves elucidating signaling pathways like GPCRs, epigenetic mechanisms, and ion channels to develop translational therapies from bench to bedside. Education: BS in Biochemistry and Molecular Biology & Chemistry/Biology, University of Miami (2011) PhD in Chemistry, Vanderbilt University (2016) MD, Medical College of Wisconsin (2021) Postdoctoral Training in Cell Biology at Medical College of Wisconsin (2024) Research Interests: Novel small molecule discovery for disease targets Epigenetic signaling and bromodomain modulation TRP channel pharmacology in parasitic diseases Design of anti-parasitic and anticancer agents Lab Highlights: Current projects include TRPM channel-based flukicide development Investigating praziquantel resistance mechanisms Optimizing CXCL12 ligands for cancer therapy Advising & Collaboration: Mentors graduate students (Erika) and undergraduates (Connor) Alumni Ana and Julia pursue graduate studies in related fields Active collaborations on opioid receptor pharmacology and mitochondrial targeting Lab Location: Basic Science Building, Room 506, Charleston SC

• Drug Discovery
• Epigenetics
• Neuroscience
• +۷ مورد دیگر

Dr. Teresa Lee is an Assistant Professor in the Department of Biological Sciences at the University of Massachusetts Lowell, part of the College of Sciences. Her research focuses on the epigenetics of longevity, chromatin structure, and transgenerational inheritance, using C. elegans as a model organism. She leads the Lee Lab, which investigates how chromatin landscapes influence aging and fertility across generations. Dr. Lee holds a BS from the University of North Carolina at Chapel Hill, a PhD from UC Berkeley, and completed her postdoctoral training at Emory University. Her work bridges molecular genetics, cell biology, and developmental biology, combining genomic tools with microscopy to explore inheritance patterns. Key findings include the discovery that elevated repressive chromatin in ancestors extends lifespan in C. elegans . Future research aims to map how transgenerational chromatin changes affect gene expression over an organism’s life cycle. Dr. Lee has received multiple accolades, including the 2024 Faculty Excellence Award for mentoring and the 2023 Teaching Excellence Award. She is committed to inclusive education, co-developing the Pipeline CURE program to integrate research into undergraduate curricula. Her grants include NIH R15 funding as Principal Investigator for projects linking chromatin to lifespan and genomic integrity in germ cells. Lab Focus: Epigenetic regulation of aging, chromatin inheritance Key Techniques: Molecular genetics, genomics, high-resolution microscopy Collaborations: Cross-disciplinary projects in epigenetics and developmental biology

• Epigenetics
• Longevity
• Chromatin
• +۳ مورد دیگر

Yael David, PhD, is an Assistant Professor in the Chemical Biology Program at Memorial Sloan Kettering Cancer Center (MSKCC). She leads a lab focused on understanding epigenetic regulation of transcription via chemical biology approaches. Her work integrates biochemistry, cell biology, and protein engineering to study histone modifications in health and disease, particularly cancer and diabetes. David holds a PhD from the Weizmann Institute of Science and conducted postdoctoral research at Princeton University under Tom Muir. She is affiliated with the Tri-Institutional Chemical Biology Program (TPCB) and has received awards including the Josie Robertson Investigatorship and Pershing Square Sohn Cancer Alliance Award. Education: BS in Biology, Stony Brook University (2004) PhD in Biochemistry, Weizmann Institute of Science (2011) Postdoctoral Fellowship in Chemical Biology, Princeton University (2016) Research Interests: Her lab develops chemical tools to study histone modifications and their roles in chromatin dynamics, transcriptional regulation, and disease. Key areas include: Epigenetic mechanisms in cancer Non-canonical histone marks and their therapeutic targeting Chemical probes for histone modification analysis Awards: Josie Robertson Young Investigator’s award (2016–2021) CEBRA Award (2018) Pershing Square Sohn Cancer Alliance Award Lab Affiliations: David’s lab is part of the TPCB and collaborates widely. Current projects include investigating histone glycation’s role in disease and developing novel epigenetic therapies.

• Epigenetics
• Chemical Biology
• Cancer Biology
• +۳ مورد دیگر

Jesús de la Cruz is a Lecturer in Genetics at the Department of Genetics, Faculty of Biology, University of Seville, Spain. He leads the Jesús de la Cruz Lab located at the Institute of Biomedicine of Seville (IBiS) within the "Virgen del Rocío" University Hospital Campus. His research focuses on ribosome assembly and gene expression in eukaryotes, with particular emphasis on understanding the complex process of ribosome biogenesis in yeast as a model system. Dr. de la Cruz's primary research interest lies in studying the fundamental process of ribosome assembly in eukaryotes. His laboratory investigates how ribosomal proteins and assembly factors contribute to the maturation of both 40S and 60S ribosomal subunits. The team's work has revealed critical insights into the roles of specific ribosomal proteins (such as eL15, eL36, eS12), RNA helicases (including Dbp7), and other assembly factors in the stepwise construction of functional ribosomes. Their research demonstrates that eukaryotic ribosome biogenesis is considerably more complex than prokaryotic ribosome assembly, requiring numerous trans-acting factors and intricate quality control mechanisms. Analysis of Dr. de la Cruz's most recent publications reveals a consistent focus on ribosome structure, assembly, and function, with particular attention to the roles of specific ribosomal proteins and assembly factors. His work spans multiple aspects of ribosome biology including the maturation of ribosomal subunits, the connection between ribosome biogenesis and translation, and the impact of ribosome dysfunction on cellular processes. The research utilizes Saccharomyces cerevisiae (budding yeast) as a primary model system, taking advantage of its well-characterized genetics and conserved eukaryotic features. Dr. de la Cruz actively collaborates with numerous international research groups including the Woolford lab at Carnegie Mellon University (USA), the Henry/Henras lab at CBI in Toulouse (France), the Kressler lab at the University of Fribourg (Switzerland), and the Panse lab at the University of Zurich (Switzerland), among others. These collaborations focus on various aspects of ribosome biogenesis, from structural characterization to functional analysis of assembly factors. His laboratory is part of the Research Unit "Gene Expression in Eukaryotes" at IBiS, Spain, working closely with the groups of M.C. Muñoz-Centeno/S. Chávez and F. Gómez-Herreros. The Jesús de la Cruz Lab is located in Lab 201 at the Institute of Biomedicine of Seville, where they maintain active research programs investigating ribosome synthesis and function. The laboratory welcomes postdoctoral researchers, PhD students, and undergraduate students interested in molecular genetics and ribosome biology. Their work has significant implications for understanding fundamental cellular processes and may inform research on human diseases related to ribosome dysfunction.

• Ribosome Biogenesis
• Gene Expression
• Molecular Genetics
• +۴ مورد دیگر

Y. George Zheng, Ph.D., serves as the Panoz Professor of Pharmacy within the Department of Pharmaceutical and Biomedical Sciences at the University of Georgia College of Pharmacy. His academic leadership contributes to the institution's recognition as a top-15 pharmacy program nationally, with research spanning epigenetic mechanisms and therapeutic development. Dr. Zheng's work centers on epigenetic enzymology , specifically protein arginine methyltransferases (PRMTs) and histone acetyltransferases (HATs). His laboratory investigates molecular mechanisms of histone modifications—including methacrylation, benzoylation, and acetoacetylation—and develops chemical probes targeting enzymes involved in cancer pathways and viral replication. Research integrates chemical biology , structural analysis , and high-throughput screening to translate basic discoveries into therapeutic strategies for leukemia, neuroblastoma, and infectious diseases. Analysis of his recent publication record reveals sustained innovation in epigenetic drug discovery, with emphasis on PRMT enzyme regulation, novel histone mark characterization, and antiviral agent development against SARS-CoV-2 methyltransferases. His work demonstrates consistent methodological advancement in assay design and inhibitor screening, establishing foundational knowledge for targeting epigenetic dysregulation in disease. Dr. Zheng holds the distinguished Panoz Professorship, an endowed chair recognizing exceptional scholarly contributions to pharmaceutical sciences. While specific mentoring details are not enumerated, Dr. Zheng actively guides graduate researchers in the Pharmaceutical and Biomedical Sciences program. His externally funded laboratory employs interdisciplinary approaches to dissect epigenetic mechanisms, with grant support enabling cutting-edge instrumentation for biochemical and cellular studies. The Zheng laboratory maintains a dynamic research environment focused on elucidating biological functions of emerging histone modifications and advancing targeted epigenetic therapeutics toward preclinical validation.

• Epigenetics
• Biochemistry
• Cancer Biology
• +۲ مورد دیگر

Serge McGraw is a Professor in the Department of Obstetrics and Gynecology at the University of Montreal’s Faculty of Medicine. He leads the Laboratoire d'Épigénétique du Développement et du Neurodéveloppement , focusing on epigenetic dysregulation in developmental and neurodevelopmental disorders. His research integrates genetic and environmental models, including mouse embryos, stem cells, and patient-derived iPSCs. Key projects address inherited epigenetic errors, fetal alcohol spectrum disorder (FASD), and mutations in epigenetic genes like DNMT3A. Education: PhD in Reproductive Biology (Laval University, 2007), postdoctoral training in epigenetics at McGill University (2007–2014). Additional degrees include a BSc in Biochemistry (Laval, 2000), and a diploma in Health Sciences (University of Moncton, 1997). Research Expertise: Developmental origins of health and disease (DOHAD), FASD mechanisms, rare epigenetic syndromes (e.g., TBRS), and multi-omics approaches. His work bridges basic science and translational medicine, targeting epigenetic therapies for neurodevelopmental disorders. Awards: Senior Research Scholar, Fonds de recherche du Québec-Santé (2024) Knowledge Mobilization Prize (RQR, 2024, 2022) Junior Research Scholar awards (FRQS, 2020, 2016) Teaching & Supervision: Advised over 10 graduate students since 2018, focusing on epigenetic mechanisms, FASD, and TBRS. Active in obstetrics/gynecology training programs. Affiliations: Researcher at CHU Sainte-Justine, member of the Azrieli Research Center and Réseau Québécois en Reproduction (RQR). Deputy Head of the Feto-Maternal and Neonatal Pathologies research axis.

• Developmental Epigenetics
• Neurodevelopmental Disorders
• Fetal Alcohol Spectrum Disorder (FASD)
• +۳ مورد دیگر

Carlo Yague-Sanz is a Researcher affiliated with the University of Namur, specifically within the Namur Research Institute for Life Sciences and the Namur Institute for Complex Systems. He holds a Doctor of Sciences degree, as evidenced by his 2018 thesis on RNA polymerase II CTD phosphorylation. His research focuses on RNA biology, transcription mechanisms, chromatin structure, and fungal genetics, with particular emphasis on RNA polymerases' roles in gene regulation and chromatin interactions. Dr. Yague-Sanz has led two major research projects: one exploring microRNA-like biogenesis in fission yeast and another investigating RNA polymerase II's role in priming chromatin for RNA polymerase III transcription. His work contributes to UN Sustainable Development Goals related to advancing health and life sciences. Recent publications highlight his expertise in antisense transcription regulation, RNA processing, and epigenetic mechanisms. He collaborates internationally and has authored over 16 peer-reviewed articles and reviews. Key achievements include pioneering the Rho-seq method for RNA modification mapping and revealing novel roles of RNA-binding proteins in ribosomal RNA processing. His research bridges fundamental molecular biology with applications in understanding cellular differentiation and gene expression control.

• RNA Biology
• Gene Regulation
• Transcription Mechanisms
• +۳ مورد دیگر

Dr. Kenneth W. Berendzen is a Senior Researcher and Staff Scientist at the Center for Plant Molecular Biology (ZMBP) at the University of Tübingen, Germany. He serves as the Shared Resource Lab Manager for both the FACS and Transformation Departments at ZMBP, where he oversees critical core facilities supporting plant molecular biology research. His position within the Faculty of Science places him at the intersection of advanced technological support and cutting-edge plant research. Dr. Berendzen's research program focuses on protein-protein and protein-DNA network interactions of transcription factors in plants. His work employs diverse methodologies including Genetics, FACS and Flow Cytometry, Reporter-gene assays, Cloning, Tissue-culture, protoplast generation and transfection, Protein-protein interaction assays, and Bio-Informatics. He primarily works with Arabidopsis thaliana plants and cell-cultures, as well as Nicotiana benthamiana . A significant portion of his research involves the two-component system (TCS) in plants, also known as the Multi-Step Phosphorelay, which is an evolutionarily conserved signaling mechanism from bacteria to plants. His publication record demonstrates consistent contributions to plant molecular biology, with recent work focusing on transcription factor networks, chromatin organization, plant hormone signaling, and advanced methodologies for studying protein interactions. The 15 most recent publications reveal a strong emphasis on plant signaling mechanisms, nuclear organization, and innovative technical approaches that bridge computational and experimental biology. Dr. Berendzen teaches within both the Plant Physiology Department and the Nano Science Department, offering lectures and practical courses at the Bachelor and Master levels. He welcomes students interested in lab rotations or practical courses to visit his office on the 5th floor, West Wing, room 5X17 at ZMBP. He is the principal creator and developer of Motif Mapper, a collection of scripts for various word counting tasks in DNA sequence analysis. This open-source software package has been widely used in bioinformatics research and has evolved through multiple versions including VBA, .NET, and Python implementations. His technical expertise extends to developing specialized methodologies such as animation of the two-component system using Blender and various bioinformatics tools for protein-protein interaction mining.

• Plant Molecular Biology
• Transcription Factors
• Protein-Protein Interactions
• +۵ مورد دیگر

Jeffrey S. Smith is a Professor of Biochemistry and Molecular Genetics at the University of Virginia School of Medicine, with a courtesy appointment in another department. His research focuses on transcriptional silencing mechanisms and aging processes in Saccharomyces cerevisiae (yeast). Key areas include rDNA chromatin structure, epigenetic regulation, and metabolic pathways influencing longevity. Smith holds a BS in Marine Biology from LIU Southampton, a PhD in Biochemistry from the University of Medicine and Dentistry/RWJMS, and postdoctoral training in Molecular Biology at Johns Hopkins School of Medicine. His research interests emphasize how chromatin organization and metabolic signaling modulate yeast aging. Notable projects include studying Sir2-regulated silencing, caloric restriction effects on lifespan, and the role of cohesin complexes in genomic stability. His recent work explores mechanisms linking rDNA transcription to replicative aging and identifies small molecules like isonicotinamide that extend chronological lifespan. Publications highlight interdisciplinary approaches in yeast genetics, biochemistry, and systems biology. While no explicit awards are listed, his work has contributed significantly to understanding fundamental aging mechanisms. Advising and grant details are not provided here, but his lab focuses on yeast models to dissect epigenetic and metabolic pathways.

• Biochemistry
• Epigenetics
• Genetics
• +۳ مورد دیگر