Jeffrey S. Smith

Jeffrey S. Smith is a Professor of Biochemistry and Molecular Genetics at the University of Virginia School of Medicine, with a courtesy appointment in another department. His research focuses on transcriptional silencing mechanisms and aging processes in Saccharomyces cerevisiae (yeast). Key areas include rDNA chromatin structure, epigenetic regulation, and metabolic pathways influencing longevity. Smith holds a BS in Marine Biology from LIU Southampton, a PhD in Biochemistry from the University of Medicine and Dentistry/RWJMS, and postdoctoral training in Molecular Biology at Johns Hopkins School of Medicine.

His research interests emphasize how chromatin organization and metabolic signaling modulate yeast aging. Notable projects include studying Sir2-regulated silencing, caloric restriction effects on lifespan, and the role of cohesin complexes in genomic stability. His recent work explores mechanisms linking rDNA transcription to replicative aging and identifies small molecules like isonicotinamide that extend chronological lifespan.

Publications highlight interdisciplinary approaches in yeast genetics, biochemistry, and systems biology. While no explicit awards are listed, his work has contributed significantly to understanding fundamental aging mechanisms. Advising and grant details are not provided here, but his lab focuses on yeast models to dissect epigenetic and metabolic pathways.