Daniel Sprague

Dr. Daniel Sprague, MD, PhD is an Adjunct Assistant Professor in the Department of Biochemistry and Molecular Biology at the Medical University of South Carolina (MUSC). He leads the Sprague Lab, focused on discovering small molecules targeting diseases such as neglected tropical diseases, cancer, and neurotransmission disorders. His work involves elucidating signaling pathways like GPCRs, epigenetic mechanisms, and ion channels to develop translational therapies from bench to bedside.

• Education:
  • BS in Biochemistry and Molecular Biology & Chemistry/Biology, University of Miami (2011)
  • PhD in Chemistry, Vanderbilt University (2016)
  • MD, Medical College of Wisconsin (2021)
  • Postdoctoral Training in Cell Biology at Medical College of Wisconsin (2024)
• Research Interests:
  • Novel small molecule discovery for disease targets
  • Epigenetic signaling and bromodomain modulation
  • TRP channel pharmacology in parasitic diseases
  • Design of anti-parasitic and anticancer agents
• Lab Highlights:
  • Current projects include TRPM channel-based flukicide development
  • Investigating praziquantel resistance mechanisms
  • Optimizing CXCL12 ligands for cancer therapy
• Advising & Collaboration:
  • Mentors graduate students (Erika) and undergraduates (Connor)
  • Alumni Ana and Julia pursue graduate studies in related fields
  • Active collaborations on opioid receptor pharmacology and mitochondrial targeting
• Lab Location:

  Basic Science Building, Room 506, Charleston SC