معرفی
Jesús de la Cruz is a Lecturer in Genetics at the Department of Genetics, Faculty of Biology, University of Seville, Spain. He leads the Jesús de la Cruz Lab located at the Institute of Biomedicine of Seville (IBiS) within the "Virgen del Rocío" University Hospital Campus. His research focuses on ribosome assembly and gene expression in eukaryotes, with particular emphasis on understanding the complex process of ribosome biogenesis in yeast as a model system.
Dr. de la Cruz's primary research interest lies in studying the fundamental process of ribosome assembly in eukaryotes. His laboratory investigates how ribosomal proteins and assembly factors contribute to the maturation of both 40S and 60S ribosomal subunits. The team's work has revealed critical insights into the roles of specific ribosomal proteins (such as eL15, eL36, eS12), RNA helicases (including Dbp7), and other assembly factors in the stepwise construction of functional ribosomes. Their research demonstrates that eukaryotic ribosome biogenesis is considerably more complex than prokaryotic ribosome assembly, requiring numerous trans-acting factors and intricate quality control mechanisms.
Analysis of Dr. de la Cruz's most recent publications reveals a consistent focus on ribosome structure, assembly, and function, with particular attention to the roles of specific ribosomal proteins and assembly factors. His work spans multiple aspects of ribosome biology including the maturation of ribosomal subunits, the connection between ribosome biogenesis and translation, and the impact of ribosome dysfunction on cellular processes. The research utilizes Saccharomyces cerevisiae (budding yeast) as a primary model system, taking advantage of its well-characterized genetics and conserved eukaryotic features.
Dr. de la Cruz actively collaborates with numerous international research groups including the Woolford lab at Carnegie Mellon University (USA), the Henry/Henras lab at CBI in Toulouse (France), the Kressler lab at the University of Fribourg (Switzerland), and the Panse lab at the University of Zurich (Switzerland), among others. These collaborations focus on various aspects of ribosome biogenesis, from structural characterization to functional analysis of assembly factors. His laboratory is part of the Research Unit "Gene Expression in Eukaryotes" at IBiS, Spain, working closely with the groups of M.C. Muñoz-Centeno/S. Chávez and F. Gómez-Herreros.
The Jesús de la Cruz Lab is located in Lab 201 at the Institute of Biomedicine of Seville, where they maintain active research programs investigating ribosome synthesis and function. The laboratory welcomes postdoctoral researchers, PhD students, and undergraduate students interested in molecular genetics and ribosome biology. Their work has significant implications for understanding fundamental cellular processes and may inform research on human diseases related to ribosome dysfunction.
