جست‌وجوی استاد و پژوهشگر

Tahira Riazمشاهده پروفایل

مدرس

• Mass spectrometry
• Proteomics
• Bioinformatics
• +۳ مورد دیگر

Tahira Riaz is a Lecturer and Senior Engineer in the Department of Microbiology at the University of Oslo, affiliated with the Faculty of Medicine. Her research focuses on antimicrobial resistance, particularly Mycobacterium tuberculosis (Mtb) biofilm formation and drug discovery. She leads a postdoctoral project funded by the EU’s Joint Programming Initiative on Antimicrobial Resistance (JPIAMR), investigating novel Mycobacterial Tolerance Inhibitors (MTIs) against multidrug-resistant TB. Riaz’s work combines mass spectrometry, proteomics, and mutant analysis to uncover MTIs’ mechanisms of action and synergy with existing TB drugs. Her teaching roles include supervising Bachelor’s students and leading microbiology laboratory courses for medical students. She has held deputy roles representing temporary academic staff on institutional councils. Key research interests include proteomics, immunology, and bioinformatics, with a focus on understanding bacterial pathogenesis and developing precision medicine strategies. Riaz’s publications span proteomic analyses of Mtb strains, Alzheimer’s disease biomarkers, and bacterial DNA repair mechanisms. She collaborates internationally on projects addressing antimicrobial resistance and drug discovery. Her work bridges fundamental research with clinical applications, emphasizing translational outcomes in infectious disease management.

Amy Whitakerمشاهده پروفایل

استادیار مدعو

• DNA Repair
• Transcriptional Regulation
• Cancer Biology
• +۳ مورد دیگر

Dr. Amy Whitaker is an Adjunct Assistant Professor in the Department of Biochemistry and Molecular Biology at Drexel University College of Medicine. She leads the Whitaker Lab, where her research focuses on molecular mechanisms linking DNA damage responses and gene regulation in cancer development. Her primary research investigates two interconnected biological processes: Base excision repair (BER) pathways for oxidative DNA damage Epigenetic-like transcriptional regulation of tumor suppressors and oncogenes This work specifically targets G-quadruplex forming sequences, with the long-term goal of identifying novel therapeutic targets for cancer treatment.

Rawle Philbertمشاهده پروفایل

استاد

• Oral Surgery
• Maxillofacial Surgery
• Trauma Surgery
• +۳ مورد دیگر

Dr. Rawle Philbert serves as Chief of the Division of Oral and Maxillofacial Surgery at the University of Texas Southwestern Medical Center, where he previously led the Oral and Maxillofacial Surgery residency program for over two decades and chaired the Dentistry and OMS department. His expertise spans surgical innovation, trauma management, and complex reconstructive procedures in maxillofacial surgery. Education: He graduated from Howard University College of Dentistry and completed an oral and maxillofacial surgery residency at Harlem Hospital Center. Research focuses on surgical techniques for mandibular fractures, bone grafting, and managing maxillofacial pathologies. His work emphasizes evidence-based practices and multidisciplinary care, as seen in over two dozen peer-reviewed articles published in journals like Journal of Oral and Maxillofacial Surgery and European Journal of Oral and Maxillofacial Surgery . Awards include the Lincoln Medical Center Auxiliary Lifetime Achievement Award and New York City Health and Hospital Corporation Doctor of the Year Award, recognizing his contributions to patient care and surgical education. Dr. Philbert has advised multiple residents through his residency program and contributed to advancing surgical protocols in oral trauma and implantology. His clinical interests include complex maxillofacial reconstructions and managing rare tumors, with a focus on improving patient outcomes through innovative techniques.

Nigel Brissettمشاهده پروفایل

مدرس ارشد

• Protein Biochemistry
• DNA Damage and Repair
• Structural Biology
• +۳ مورد دیگر

Nigel Brissett is a Senior Lecturer at the University of Brighton's School of Applied Sciences, affiliated with the Centre for Lifelong Health. His research focuses on protein biochemistry, DNA damage response mechanisms, and fetal alcohol spectrum disorder (FASD). He holds a PhD from the University of London (1996) and a combined Biochemistry/Chemistry degree from Aston University (1991). Research interests include structural biology of protein-DNA interactions, prokaryotic DNA repair enzymes, and FASD's molecular effects. He applies biochemical approaches to study prenatal alcohol exposure's impact on skeletal development and metabolic processes. Nigel teaches biochemistry and metabolic pathways, emphasizing research-integrated pedagogy and student engagement. Previous roles include postdoctoral research at the University of Sussex (1997-2005) and the Genome Damage and Stability Centre (2005-2019). He is a Biochemical Society Local Ambassador and holds a Postgraduate Certificate in Learning and Teaching in Higher Education.

Amy Whitakerمشاهده پروفایل

استادیار

• DNA Repair
• Oxidative DNA Damage
• Cancer Genetics
• +۳ مورد دیگر

Amy Whitaker is an Assistant Professor at Temple University’s Fox Chase Cancer Center, affiliated with the Cancer Epigenetics Institute Research Program. She holds a PhD in Biochemistry and Biophysics from Texas A&M University and a BS in Chemistry from the University of St. Thomas. Her research focuses on the interplay between DNA repair mechanisms and the transcriptional regulation of cancer-associated genes, particularly involving oxidative DNA lesions and G-quadruplex structures. Key techniques include structural biology (X-ray crystallography, Cryo-EM), nucleic acid enzymology, and single-molecule fluorescence microscopy. Dr. Whitaker has been recognized with awards such as the EMGS Newly Independent Investigator Engagement Program Awardee (2022) and the NIH Pathway to Independence Award (2020). Her lab investigates DNA repair strategies in G-quadruplex regions and their impact on tumor suppressor and oncogene expression. Recent grants include the W. W. Smith Charitable Trust Medical Research grant (2023). Current lab members include postdoc Elham Ahanin, technician Shanae Franklin, and student Christopher Merlo. Alumni include Haley Kravitz (now a PhD student at Drexel University) and Oviyanna Umoh. Her work aims to identify molecular targets for cancer therapy through mechanistic insights into DNA repair pathways.

Eva Goellnerمشاهده پروفایل

استادیار

• DNA Repair Mechanisms
• Cancer Biology
• Genetic Toxicology
• +۳ مورد دیگر

Eva Goellner is an Assistant Professor in the Department of Toxicology and Cancer Biology at the University of Kentucky. Her research focuses on understanding the molecular mechanisms linking DNA repair pathways to sensitivity toward DNA-damaging agents, particularly in cancer and environmental contexts. She holds a PhD from the University of Pittsburgh School of Medicine and completed postdoctoral training at the Ludwig Institute for Cancer Research. Education: Postdoctoral Fellowship: Ludwig Institute for Cancer Research PhD: University of Pittsburgh School of Medicine BS: Carnegie Mellon University Research interests include DNA repair mechanisms, mismatch repair pathways, and the interplay between environmental agents and genetic stability. Her lab investigates how DNA repair pathways influence cellular responses to chemotherapy and environmental toxins. Key publications highlight her work on mismatch repair proteins (e.g., Msh2, Mlh1), chromatin remodeling in DNA repair, and the role of DNA polymerase β in therapeutic interventions. She has contributed to understanding how proteins like HLTF and SHPRH interact with mismatch repair systems.

David M Wilson IIIمشاهده پروفایل

استاد

• Genome Repair
• Neurodegenerative Diseases
• Aging Mechanisms
• +۴ مورد دیگر

Professor David M Wilson III leads the GRAND Team (Genome Repair in Aging and Neurodegenerative Disease) at Hasselt University. His research focuses on delineating genome maintenance mechanisms in neurodegenerative conditions and developing strategies to promote healthy aging. Previously, he held senior positions at Lawrence Livermore National Laboratory and the National Institute on Aging (NIH). Education: Bachelor of Arts in Biology & Political Science, Bucknell University PhD in Molecular Biology, Loyola University – Stritch School of Medicine Post-doctoral Training in Molecular Toxicology, Harvard School of Public Health Research Focus: The GRAND Team investigates biochemical mechanisms of DNA repair systems, particularly oxidative damage resolution. Key aims include defining how repair defects drive degenerative diseases/aging and developing therapies to preserve genome integrity and extend healthspan. Core interests span DNA damage susceptibility, neurodegenerative pathways, and oxidative stress in aging. Active Funding: Alzheimer Research Foundation (SAO-FRA, 2023–2026): Targeting DNA repair mechanisms against Aβ-Tau-induced neuronal loss Research Foundation – Flanders (FWO, 2025–2029): Genomic stress resolution in gut disorders involving enteric nervous defects Professional Service: Current Roles: Reviews Editor for Cellular and Molecular Life Sciences and Frontiers Aging ; EMBL Representative. Past: Editorial boards of 6+ journals including Nucleic Acids Research ; Executive roles in Environmental Mutagenesis Society; Grant reviewer for NIH/NWO. Advising & Team Leadership: Leads 2 PhD students, 2 Master's candidates, and postdoctoral researchers in the GRAND Team. Alumni include 16+ PhD/Master's graduates from current and prior institutions (NIA, Lawrence Livermore).

Joshua Burgessمشاهده پروفایل

استاد مهمان

• Medical biochemistry
• Metabolomics
• Medical microbiology
• +۳ مورد دیگر

Dr. Joshua Burgess is a Visiting Professor in the School of Biomedical Sciences at Queensland University of Technology (QUT), within the Faculty of Health. His research focuses on medical biochemistry, metabolomics, and medical microbiology, with a particular emphasis on DNA repair mechanisms, cancer therapeutics, and protein interactions in oncology. He holds a PhD and dual bachelor’s degrees in Biomedical Science and Biotechnology from QUT. His work investigates how proteins like Banf1, COMMD4, and ALDOA influence DNA repair pathways and tumorigenesis. Key areas include PARP inhibitor mechanisms, epigenetic regulation of DNA damage repair, and targeted therapies for lung and breast cancers. Collaborations with institutions like QUT’s Centre for Genomics and Personalised Health drive translational research in precision oncology. Burgess’ recent studies explore the therapeutic potential of inner nuclear membrane proteins and the role of CDCA3 in enhancing chemotherapy efficacy. His research bridges basic science and clinical applications, addressing challenges like tumor resistance and drug sensitivity. Supervision topics include UV-induced DNA damage responses, PARP inhibitor efficacy in ovarian cancer, and novel DNA repair protein characterization. While no explicit grants or awards are listed, his publications reflect active engagement in high-impact oncology research.

• Bioethics
• Biobanking Ethics
• Personalized Medicine
• +۳ مورد دیگر

Kristin Solum Steinsbekk is an Associate Professor in the Department of Biomedical Laboratory Science at the Norwegian University of Science and Technology (NTNU), affiliated with the Faculty of Natural Sciences. Her expertise spans bioethics, biobanking, and personalized medicine, with a focus on ethical challenges in genomic research and clinical applications. Her research interests include the ethical implications of commercialization in biobanking, consent models for genomic studies, and the societal impact of personalized medicine. She has contributed to interdisciplinary education initiatives, particularly in biomedical laboratory science and medical genetics, teaching courses such as HBIO3015 and HBIOT2031. Her work often addresses the balance between scientific innovation and ethical responsibility, including topics like incidental findings management, participant engagement in research, and the implications of digital health technologies. She has presented at numerous conferences, including the European Conference on Philosophy of Medicine and the Norwegian Society for Human Genetics meetings. Steinsbekk holds a doctoral degree from NTNU (2013) focusing on biobank ethics and has authored or co-authored over 20 peer-reviewed articles, covering topics from genetic mutation analysis to Kantian ethics in medical technology.

Tadahide Izumiمشاهده پروفایل

دانشیار

• DNA damage
• Mutagenesis
• Reactive oxygen species
• +۳ مورد دیگر

Tadahide Izumi, PhD, is an Associate Professor in the Department of Toxicology and Cancer Biology at the University of Kentucky. His research focuses on DNA damage and mutagenesis caused by reactive oxygen species (ROS) and exogenous agents like ionizing radiation and chemotherapy drugs. Central to his work is understanding how cellular defenses and DNA repair pathways, particularly base excision repair (BER), contribute to genomic integrity and cancer therapy resistance. Dr. Izumi’s lab investigates the regulation of APE1, a critical BER enzyme, through post-translational modifications such as oxidation/reduction and ubiquitination. This research aims to uncover mechanisms underlying cancer’s resistance to treatments, with potential applications in improving organ preservation therapies. He is also affiliated as Joint Faculty in Toxicology. No specific scientific awards or student advisees are listed in the provided information. His research highlights the dual role of BER in both maintaining genomic stability and enabling cancer resistance, emphasizing the complexity of molecular carcinogenesis.

• Computational Chemistry
• Molecular Dynamics Simulations
• QM/MM Methods
• +۱۱ مورد دیگر

Prof. Dr. Petra Imhof is a full professor of Computational Chemistry at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), where she serves as Technical Director of the Computer Chemistry Center. She leads a dynamic research group focused on understanding biomolecular processes through advanced computer simulations. Her work bridges chemistry, biology, and physics, with strong emphasis on enzyme mechanisms, DNA-protein interactions, and computational biophysics. Her research interests include: Computational modeling of enzymatic reaction mechanisms using QM/MM methods Protein-DNA recognition and specificity, especially in DNA repair enzymes like thymine DNA glycosylase and restriction endonuclease EcoRV Proton transfer dynamics in membrane proteins such as cytochrome c oxidase Allosteric communication networks in proteins Transition network analysis for complex macromolecular transitions Computational spectroscopy, including vibrational and fluorescent protein studies Her recent publications reveal a strong focus on DNA repair mechanisms, metalloenzyme inhibition, and the physical chemistry of biomolecular recognition. The works span from fundamental biophysical questions to applications in drug design and biosensor development, reflecting a deep integration of theory and biochemical insight. Prof. Imhof has mentored numerous researchers, including PhD and postdoctoral students, many of whom are listed as co-authors on her publications. She has not received any explicitly mentioned scientific awards in the provided text. She leads an active research team investigating protein dynamics, enzymatic catalysis, and DNA damage recognition using molecular simulations. The group employs cutting-edge computational techniques to model complex biological systems, with applications ranging from basic science to therapeutic development.

Amanda K. McCulloughمشاهده پروفایل

استاد پژوهشی

• DNA Repair
• Genome Instability
• Cancer Biology
• +۴ مورد دیگر

Amanda K. McCullough is a Research Professor at Oregon Health & Science University (OHSU) , focusing on biochemical mechanisms of DNA repair systems and their roles in environmental stress responses. Her work bridges genome instability, cancer biology, and metabolic diseases. Education: Ph.D. in Cellular and Molecular Biology, University of Vermont (1992) Postdoctoral Training: Oregon Health & Science University, University of Texas Medical Branch Her research investigates DNA damage response pathways in carcinogenesis, particularly aflatoxin- and UV-induced mutations, NEIL1 glycosylase functions, and small molecule inhibitors for cancer therapy. Recent studies explore links between DNA repair defects and colorectal cancers/metabolic disorders , as well as protein-DNA interactions in neurodegenerative diseases. Key trends in her 15 most recent articles (2025–2019) include aflatoxin mutagenesis, NEIL1 polymorphisms across populations, abasic site targeting by chemotherapeutic agents, and DNA repair modulation for cancer treatment. Awards include the 2017 OHSU Excellence in Teaching .

David K. Cortezمشاهده پروفایل

استاد

• DNA Damage Response
• Genome Integrity
• DNA Repair
• +۷ مورد دیگر

David K. Cortez is Professor of Biochemistry and Chair of the Department of Biochemistry at Vanderbilt University School of Medicine. He also holds the Richard N. Armstrong Ph.D. Chair for Innovation in Biochemistry and serves as Associate Director for Basic Science Research at the Vanderbilt-Ingram Cancer Center. His research is centered on genome maintenance, DNA damage response, and replication stress mechanisms. Institution: Vanderbilt University School: School of Medicine Department: Department of Biochemistry Leadership: Chair of Biochemistry, Associate Director (Basic Science), VICC Contact: david.cortez@vanderbilt.edu | 615-322-8547 | 613 Light Hall, Nashville, TN Dr. Cortez's research focuses on understanding how cells maintain genome integrity during DNA replication and in response to DNA damage. His work integrates genetics, biochemistry, cell biology, proteomics, and structural biology to dissect mechanisms involving ATR kinase signaling, replication fork remodeling, BRCA-related pathways, abasic site repair, and proteolysis . These processes are crucial for preventing cancer, developmental disorders, and aging. The 15 most recent publications highlight a consistent focus on DNA damage signaling, replication fork dynamics, and repair mechanisms . Key themes include the use of iPOND for proteomic mapping , fork regression and protection , ATR-mediated checkpoint control , and therapeutic targeting of DNA repair pathways in cancer. Subfields span molecular oncology, signal transduction, and structural enzymology. Scientific recognition includes: Richard N. Armstrong Ph.D. Chair for Innovation in Biochemistry Dr. Cortez leads an active research program with ongoing postdoctoral recruitment, indicating strong grant support and mentoring activity. His lab is embedded in multiple interdisciplinary centers, including the Genome Maintenance Program (Vanderbilt-Ingram Cancer Center), Vanderbilt Institute of Chemical Biology, and Center in Molecular Toxicology , reflecting broad collaborative and funding networks. He advises graduate and postdoctoral researchers in molecular cancer biology and DNA repair. Future work continues to explore therapeutic vulnerabilities in DNA repair-deficient cancers. The Cortez Lab maintains a strong presence in both basic and translational research, with ongoing projects aimed at identifying novel repair proteins, characterizing fork protection mechanisms, and developing cancer therapies targeting the DNA damage response. The lab utilizes cutting-edge techniques such as genetic screens, iPOND, structural biology, and preclinical models.

Kathleen L. O'Connorمشاهده پروفایل

استاد

• Cancer Biology
• Integrin Signaling
• Metastasis
• +۷ مورد دیگر

Kathleen L. O'Connor is a Professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky and a key figure at the Markey Cancer Center, where she serves as Associate Director of Cancer Education and Mentoring and Director of the Markey STRONG Scholars and Post-baccalaureate Fellows Programs. Her work bridges fundamental molecular research with translational oncology and cancer education. Her educational journey includes a B.S. from James Madison University (1988), a Ph.D. from Case Western Reserve University (1996), and post-doctoral training at Harvard Medical School (2001). Dr. O'Connor's research centers on integrin signaling, particularly the role of integrin α6β4 in promoting carcinoma invasion and metastasis. Her work has revealed critical links between integrin signaling and pathways such as cAMP, RhoA activation, NFAT transcription factors, and DNA repair mechanisms including base excision and nucleotide excision repair. She has identified how integrin α6β4 drives epigenetic changes like promoter demethylation of pro-metastatic genes (e.g., S100A4, amphiregulin) and contributes to the aggressive phenotype of triple-negative breast cancer (TNBC). Her recent publications reflect a strong focus on metastasis mechanisms, DNA repair modulation by integrins, cancer metabolism, and therapeutic targeting. Themes across her work include signal transduction, tumor microenvironment interactions, and epigenetic regulation in cancer progression. Integrin α6β4 signaling in cancer DNA repair and epigenetic regulation Metastasis in breast and lung cancers Targeting S100A4 and integrins for therapy Cancer education and mentoring She has no listed scientific awards in the provided text but plays a major role in mentoring and program leadership. Her grants and funding are implied through her extensive publication record and leadership in cancer training programs. She advises students and postdocs, though specific names are not listed. Dr. O'Connor leads the STRONG Scholars Program, a comprehensive initiative for training underrepresented students in cancer research, and is deeply involved in shaping cancer education at the institutional level. Her lab investigates how integrin signaling networks drive invasive growth and therapeutic resistance, with future work likely focused on translating these findings into precision medicine strategies for TNBC.

• Antimicrobial Resistance
• Infectious Diseases
• Bacterial Pathogenesis
• +۵ مورد دیگر

Dr. Arya Gupta serves as a Senior Lecturer in Biomedical Sciences at Leeds Beckett University's School of Health and Centre for Biomedical Science Research, teaching Microbial World, Medical & Environmental Microbiology, Public Health Epidemiology, and Enterprise Biomedical Science courses. His academic journey includes a BSc in Microbiology from St. Xavier's College (Kolkata), an MSc in Bioscience (Infection and Immunity) from the University of Leeds, and a PhD from Leeds (2017) focused on aminoacyl-tRNA synthetase inhibitors for bacterial infections. Gupta's research centers on antimicrobial resistance (AMR) in MRSA and ESKAPE pathogens, with three core pillars: developing novel treatment regimes through drug repurposing to enhance antibiotic efficacy, investigating MRSA-nasal microbiota interactions, and creating point-of-care diagnostic tools. His interdisciplinary approach bridges molecular microbiology, public health, and translational innovation, notably through pro bono consulting for PHappi's women's health initiatives. Analysis of his 15 most recent publications (2018-2024) reveals dominant themes in DNA repair-targeted combinatorial therapies (leveraging cancer drugs against resistant bacteria), bacteriophage-mediated AMR transfer dynamics, and polymicrobial infection models using artificial sputum systems. His work consistently emphasizes molecular mechanisms underlying resistance evolution and therapeutic counterstrategies. Since 2021, Gupta has contributed scientific expertise to PHappi's UTI treatment development while maintaining active research collaborations. His prior roles include postdoctoral positions at St. George's University of London (developing MRSA resistance transfer assays) and University of Kent (targeting DNA repair in cancer-related infections), followed by a Knowledge Transfer Partnership at Leeds focused on aviation fuel contamination detection. He actively participates in the Centre for Biomedical Science Research, leading projects on AMR mechanisms and diagnostic development while fostering cross-disciplinary partnerships in infectious disease research.