Tadahide Izumi

Tadahide Izumi, PhD, is an Associate Professor in the Department of Toxicology and Cancer Biology at the University of Kentucky. His research focuses on DNA damage and mutagenesis caused by reactive oxygen species (ROS) and exogenous agents like ionizing radiation and chemotherapy drugs. Central to his work is understanding how cellular defenses and DNA repair pathways, particularly base excision repair (BER), contribute to genomic integrity and cancer therapy resistance.

Dr. Izumi’s lab investigates the regulation of APE1, a critical BER enzyme, through post-translational modifications such as oxidation/reduction and ubiquitination. This research aims to uncover mechanisms underlying cancer’s resistance to treatments, with potential applications in improving organ preservation therapies. He is also affiliated as Joint Faculty in Toxicology.

No specific scientific awards or student advisees are listed in the provided information. His research highlights the dual role of BER in both maintaining genomic stability and enabling cancer resistance, emphasizing the complexity of molecular carcinogenesis.