Joe Cassar

Joe Cassar is a Research Fellow in Integrative Structural Biology at the University of Birmingham, affiliated with the Cancer and Genomic Sciences department. His work focuses on molecular mechanisms underlying DNA repair and cancer resistance, particularly involving chromatin dynamics and ubiquitin signaling pathways.

• Cancer and Genomic Sciences

Research Interests:

• Integrative Structural Biology
• Genomics
• Molecular Biology
• DNA Repair
• Protein Interactions
• Ubiquitin Signaling

Recent Research Output: In 2025, he contributed to a groundbreaking article in Nature Communications analyzing how the PIN1-SUMO2/3 motif modulates RNF168 chromatin accumulation to promote ionizing radiation resistance. This work intersects structural biology, molecular oncology, and post-translational modification studies.

Collaborations: Active in international networks, his research involves collaborations with experts in chromatin biology and ubiquitin signaling, with dataset contributions from University of Birmingham researchers.