معرفی
Dr John J Reynolds is a Lecturer in Biomedical Sciences at the School of Biosciences, College of Health and Life Sciences, Aston University, United Kingdom. He is actively engaged in research on DNA repair mechanisms, genome instability, and their roles in human diseases such as cancer and neurological disorders. His work bridges molecular biology and translational medicine, with a focus on identifying therapeutic vulnerabilities in DNA repair-deficient cancers.
- PhD in Biochemistry, University of Sussex (2006–2010)
- MBiolSci in Genetics and Microbiology, University of Sheffield (2002–2006)
His research interests center on understanding how cells detect and repair DNA damage, protect DNA replication under stress, and how defects in these processes lead to diseases. He investigates the molecular basis of genome instability, particularly in the context of BRCA1 mutations, R-loop accumulation, and replication stress. His work has significant implications for developing targeted therapies for cancers with defective DNA repair pathways.
His recent publications highlight trends in DNA damage signaling, ubiquitin-mediated regulation, and chromosomal instability. Key themes include transcription-replication conflicts, RNF168 and RNF8 ubiquitin ligases, and novel pathogenic variants in DNA repair genes like SLF2 and SMC5. His research often involves collaborative, multidisciplinary studies published in high-impact journals such as Nature Communications and Nucleic Acids Research.
Dr Reynolds has supervised PhD students, including Dr Laura Grange (completed 2022) and current student Louise Longhurst (MIBTP PhD, 2024–2028). He has received research funding through collaborative grants, though specific awards are not listed. He holds an honorary Research Fellow position at the Institute of Cancer and Genomic Sciences, University of Birmingham, reflecting ongoing collaboration.
His research is associated with the Biosciences Research Group (BRG) and the Aston Research Centre for Health in Ageing. He is part of a broader network studying aging and genomic integrity, contributing to understanding age-related diseases linked to DNA damage accumulation.
