جست‌وجوی استاد و پژوهشگر

Alayna E. Loiselleمشاهده پروفایل

استاد

• Tendon Healing
• Musculoskeletal Biology
• Fibrosis
• +۳ مورد دیگر

Alayna E. Loiselle, Ph.D., is a Professor in the Department of Orthopaedics and holds joint appointments in Biomedical Engineering and Pathology & Laboratory Medicine at the University of Rochester School of Medicine and Dentistry (SMD). She leads the Musculoskeletal and Soft Tissue Fibrosis and Regeneration Lab, focusing on tendon healing mechanisms, fibrosis, and aging-related degeneration. Her work integrates molecular, cellular, and biomechanical approaches to identify therapeutic targets for tendon injuries. Dr. Loiselle's research has been recognized with awards such as the 2022 Kappa Delta Young Investigator Award and the Goldner Pioneer Award (2014). Education includes a PhD from the University of Rochester School of Medicine & Dentistry (2009), a BS in Biology from Niagara University (2004), and postdoctoral training at Penn State College of Medicine (2013). Her lab investigates cellular lineages (e.g., Scleraxis/S100a4) driving fibrotic responses, age-related tendon dysfunction, and diabetes-induced healing impairments. Recent studies highlight macrophage-myofibroblast interactions and spatial transcriptomics in tendon healing. Key projects include tendon regeneration strategies, lifespan maintenance of tendon structure, and soft tissue fibrosis mechanisms. Dr. Loiselle advises graduate students like Katherine Best and Jess Ackerman, and collaborates with institutions like the Center for Musculoskeletal Research. Her lab actively seeks candidates for PhD and postdoctoral positions in musculoskeletal biology. Scientific contributions span over 50 peer-reviewed articles, including work on NF-κB signaling in tendon fibrosis and partial reprogramming to combat aging-related degeneration. Grants support investigations into biologic factors in tendon healing and translational therapies. Lab affiliations include the BME PhD Program and Cell Biology of Disease PhD Program at URMC.

• Gene Expression Regulation
• Post-Transcriptional Regulation
• MicroRNA Biology
• +۳ مورد دیگر

Dr. Kate Dredge is a Research Fellow at the School of Biomedicine, University of Adelaide, within the Faculty of Health and Medical Sciences. She joined in 2023 to help establish the Development and Epigenetics Laboratory at SAiGENCI and the Adelaide Centre for Epigenetics (ACE). Her research focuses on molecular mechanisms of gene expression, post-transcriptional regulation, and epigenetic remodelling in development and disease. PhD: Rockefeller University (New York), specializing in neuron-specific alternative splicing of pre-mRNA Postdoctoral work in Adelaide on microRNA roles in cancer metastasis and circRNA regulation Her current work uses stem cells and multi-omics approaches (ChIP-Seq, ATAC-Seq, RNA-Seq) to study epigenetic changes during cell differentiation. Key interests include enhancer activation/decommissioning and their impact on cell fate decisions. This research bridges normal development and disease mechanisms like cancer progression. Her publications span RNA biology, cancer biology, and developmental genetics, emphasizing translational and regulatory mechanisms. Collaborations with Dr. Adrienne Sullivan underscore her role in building interdisciplinary research teams.

• Evolutionary genetics
• Speciation
• Biodiversity
• +۵ مورد دیگر

Dr. Mara Lawniczak is a Senior Group Leader at the Wellcome Sanger Institute where she leads the Lawniczak Group focused on evolutionary genetics, with an Honorary Faculty appointment at Imperial College London. Her research spans three major themes: Mosquito Vector Population Genomics, Transmission biology of Plasmodium falciparum , and Biodiversity Genomics, all aimed at building genomic resources that deliver impact in malaria control while advancing evolutionary understanding. Lawniczak completed her PhD in Population Biology at UCDavis studying sexual conflict in Drosophila , followed by postdoctoral work at University College London on seminal fluid proteins and later at Imperial College London on Anopheles mosquitoes. In 2012, she received an MRC Career Development Fellowship and established her research group at the Sanger Institute in 2014. Her research interests include evolutionary genetics, speciation, biodiversity, vector population genomics, and single cell transcriptomics. She has established the Malaria Cell Atlas (an interactive single-cell transcriptomic resource across the malaria parasite lifecycle), the Anopheles funestus population genomics project, the Anopheles Reference Genomes project, the ANOSPP project, and the BIOSCAN UK project. Her work employs genomic tools ranging from whole genome sequencing to single cell RNAseq to DNA barcoding. Analysis of her recent publications reveals a strong focus on mosquito vector diversity, malaria parasite biology, and biodiversity genomics. Her team has produced high-quality reference genomes for multiple mosquito species, developed tools for species identification, and created single-cell atlases of both mosquito vectors and malaria parasites to understand transmission dynamics. Featured as a 'hero in the field' by Bill Gates (2023) MRC Career Development Fellowship (2012) Associate editor at GENETICS Dr. Lawniczak currently holds grants from MRC, Wellcome, UKRI, Horizon Europe, and the Bill and Melinda Gates Foundation. She mentors multiple students and postdoctoral fellows, and is heavily involved in the Darwin Tree of Life Project and BIOSCAN initiative to study UK insect biodiversity through DNA barcoding of 1 million insects collected over five years.

Hongyu Zhaoمشاهده پروفایل

استاد

• Biostatistics
• Computational Biology
• Genetics
• +۹ مورد دیگر

Dr. Hongyu Zhao is the Ira V. Hiscock Professor of Biostatistics and Professor of Genetics and Statistics & Data Science at Yale University. He leads interdisciplinary research at the intersection of statistics, genomics, and public health, with formal training from Peking University (BS, 1990) and University of California-Berkeley (PhD, 1995). Yale School of Public Health Yale Department of Biostatistics Yale Cancer Center Yale Center for Genomic Health Women's Health Research at Yale Connecticut Academy of Science & Engineering His research focuses on statistical method development for genomics data analysis, including genome-wide association studies , single-cell RNAseq , network modeling , and genetic risk prediction . He applies these methods to major disease areas like cancer , PTSD , neuroscience , and precision medicine . His recent publications demonstrate methodological advances in spatial transcriptomics and foundation models for multi-omics integration. He has received multiple honors including the Mortimer Spiegelman Award and Pao-Lu Hsu Award , with fellowship in AAAS, ASA, and IMS. Dr. Zhao has trained over 110 doctoral and postdoctoral researchers, many of whom hold tenured positions at leading institutions. His lab develops open-source software and contributes to major consortia like the Million Veteran Program and Connecticut Academy of Science & Engineering .

• Reproductive Biology
• Endometriosis
• Maternal-Fetal Interactions
• +۹ مورد دیگر

Asgi T Fazleabas is a Professor and University Distinguished Professor at Michigan State University (MSU), serving as Associate Chair for Research in the Department of Obstetrics, Gynecology & Reproductive Biology. He is also Director of the Center for Women's Health Research and Co-Director of the Reproductive and Developmental Sciences NIH T32 Training Program and Doctoral Student Recruitment and Retention Program (DSRRP). His career spans institutions including the University of Illinois at Chicago, where he led the Center for Women's Health and Reproduction until 2009. Education: BS in Reproductive Physiology from California State University, Fresno; PhD in Reproductive Physiology from University of Illinois at Urbana-Champaign; Postdoctoral training in Reproductive Biology/Cell and Molecular Biology at University of Florida, Gainesville. Fazleabas’s research focuses on maternal-fetal interactions , endometriosis pathophysiology , and decidualization mechanisms . His lab pioneered studies on chorionic gonadotropin’s role in pregnancy establishment and discovered NOTCH1 signaling’s importance in endometriosis-related progesterone resistance. Recent work integrates RNASeq/proteomics for biomarkers and nano-therapeutics for lesion targeting. Article trends highlight NOTCH1’s role in decidualization, microRNA dysregulation in endometriosis, and translational approaches to improve pregnancy outcomes. Grants include R01 funding for NOTCH1 signaling, microRNA, endometriosis phenotyping, and pregnancy loss risk factors.

Joseph M. Santinمشاهده پروفایل

استادیار

• Neurobiology
• Respiratory Physiology
• Neural Circuitry
• +۵ مورد دیگر

Dr. Joseph M. Santin is an Assistant Professor of Biological Sciences at the University of Missouri's College of Arts and Science. His research focuses on understanding how neural circuits maintain stability and functionality under physiological stressors such as energy deprivation, inactivity, and environmental challenges. He uses an integrative 'genes-to-behavior' approach, combining electrophysiology, molecular biology, and in vivo physiology to study respiratory control systems in amphibians, particularly the American bullfrog. Dr. Santin holds a Ph.D., M.S., and B.S. in Biological Sciences from Wright State University and the University of Akron. His work bridges fundamental neuroscience and clinical applications, aiming to uncover novel strategies for human health challenges like stroke and neurodegenerative diseases. He leads the Santin Lab, which explores neural energetics, synaptic plasticity, and circuit-level adaptations to stress. His research interests include: Neuronal energetics and energy crisis responses Neuroplasticity mechanisms in disuse and hibernation CO2/pH signaling in respiratory control neurons Neuronal survival under anoxic conditions Dr. Santin has received notable awards, including the 2025 College of Arts and Science Assistant Professor of the Year Award and the 2024 Beverly Petterson Bishop Award for Excellence in Neuroscience. His lab employs cutting-edge techniques such as patch-clamp electrophysiology, RNAseq, and in vivo respiratory measurements to elucidate how neural circuits adapt to extreme physiological challenges.

• Statistical Bioinformatics
• Precision Medicine
• Genomics
• +۵ مورد دیگر

Andy Tran is an Education-Focused Lecturer in the School of Mathematics and Statistics at The University of Sydney, part of the Faculty of Science. He holds a PhD in statistical bioinformatics from the University of Sydney. His research interests span precision medicine, computational biology, genomics, and the development of bioinformatics tools for analyzing single-cell multi-omic data and gene regulatory networks. His work integrates systems biology approaches to address challenges in cell reprogramming, allograft dysfunction, and viral pathogenesis. Tran’s publications reflect a focus on precision medicine pathways, transcriptomic analysis, and scalable methodologies for understanding cell-cell communication in diseases like COVID-19. His educational role emphasizes innovative teaching strategies using tools like SCDNEY for data storytelling. While no awards are explicitly mentioned, his contributions to computational frameworks such as scREMOTE highlight his technical expertise. He actively supervises research projects and contributes to interdisciplinary collaborations within the Faculty of Science. His research spans from foundational studies in systems biology to applied computational models, with a commitment to advancing both academic and clinical applications of bioinformatics. Current work includes optimizing multi-platform precision medicine strategies and leveraging single-cell data to decode complex biological systems.

Caroline Gargettمشاهده پروفایل

استاد مدعو

• Reproductive Biology
• Stem Cell Biology
• Endometrial Regeneration
• +۷ مورد دیگر

Caroline Gargett is an Adjunct Professor (Research) in the Department of Obstetrics & Gynaecology at Monash Health and Monash University’s Faculty of Medicine, Nursing and Health Sciences. She is a world-renowned expert in endometrial stem cell biology and leads the Endometrial Stem Cell Biology Group. Her research has established a new field in reproductive biology through the discovery of stem/progenitor cells in the human endometrium. She is actively involved in high-impact collaborative projects, including those funded by the US Department of Defense and NHMRC, and her work spans translational applications in endometriosis and pelvic organ prolapse. Her research interests center on reproductive biology, stem cell dynamics, endometrial regeneration, and regenerative medicine . She applies cutting-edge technologies such as single-cell RNAseq, ATACseq, organoid models, and patient-derived xenografts to understand endometrial function and dysfunction. Her work has significant implications for treating gynaecological disorders like endometriosis and pelvic organ prolapse, and she is pioneering cell-based therapies using endometrial mesenchymal stem cells and nanobiomaterials. The recent trend in her publications (2023–2024) emphasizes the role of menstrual fluid as a diagnostic tool, the origins of stillbirth, and the pathophysiology of endometriosis. These works reflect a shift toward non-invasive biomarker discovery, clinical study design, and interdisciplinary collaboration integrating genomics, clinical obstetrics, and tissue engineering. Society for Gynecological Investigation President’s Achievement Award (2013) Endometriosis Foundation of America (2011) European Society for Human Reproduction and Embryology Established Scientist Award (2005) Society for Reproductive Biology’s RCRH Award for research excellence (2011) NHMRC 10 of the Best Research Projects (2008) NHMRC front webpage feature (2018) Prof Gargett has secured substantial grant funding, including 7 CIA grants from NHMRC, an RD Wright CDA (2007–2011), Senior Research Fellowship (2013–2018), and an Investigator Fellowship (2020–2024). She also obtained funding from the US Department of Defense (AUD 3M, 2019–2022), SIEF (John Stocker Postdoctoral Fellowship), CASS Foundation, Cancer Council Victoria, and other philanthropic bodies. She supervises a research team of postdoctoral scientists, students, and support staff, and is accepting PhD students through Monash University’s Supervisor Connect program. She leads the Endometrial Stem Cell Biology Group, which comprises 5 postdoctoral scientists, 3 support staff, and 6 students. Her collaborative network includes Prof Grant Montgomery (University of Queensland), Prof Luk Rombauts, A/Prof Anna Rosamilia, Dr Shayanti Mukherjee, and Prof Jerome Werkmeister. She is also actively involved in professional leadership, serving on scientific advisory boards and editorial roles.

• Infectious Diseases
• HIV-Tuberculosis Co-infection
• Immune Mechanisms
• +۳ مورد دیگر

Professor Robert Wilkinson is a Professor in Infectious Diseases at Imperial College London's Faculty of Medicine (since 2007), with concurrent roles as Principal Group Leader at the Francis Crick Institute and Honorary Professor at the University of Cape Town. His research focuses on HIV-TB co-infection mechanisms, immune reconstitution inflammatory syndrome (IRIS), and tuberculosis diagnostics/prevention. Affiliations include the Institute of Infection, Vaccine Research Network, and Immuno-Pathology Network. Education: MA (Cambridge), BM BCh (Oxford), PhD (Royal Postgraduate Medical School), and multiple specialist certifications including FRCP and Fellowship of the Academy of Medical Sciences. Research emphasizes translational studies in TB pathogenesis, biomarker discovery (e.g., transcriptomic signatures), and clinical trials evaluating interventions like vitamin D supplementation and MVA85A vaccines. Key achievements include landmark studies on IPT efficacy in HIV/TB co-infected populations, identification of IL-10/IL-22 roles in TB-IRIS, and discovery of blood transcriptomic profiles predictive of TB progression. His work has influenced WHO policy and advanced understanding of TB latency, pericarditis pathogenesis, and immune modulation.

• Pulmonary Innate Immunity
• Host-Pathogen Interactions
• Cystic Fibrosis Pathogenesis
• +۴ مورد دیگر

Clemente Britto-Leon, MD is an Associate Professor in the Department of Pulmonary, Critical Care & Sleep Medicine at Yale School of Medicine. He specializes in cystic fibrosis (CF) and pulmonary critical care, with a focus on airway innate immunity and host-pathogen interactions. He leads the Adult Cystic Fibrosis Program and directs the Pulmonary and Critical Medicine Fellowship Training Program. His research combines mechanistic studies of airway proteins like SPLUNC1 with translational work on CF exacerbations and biomarker discovery. Education: MD from Universidad Central de Venezuela (2002), Internal Medicine residency at Albert Einstein Medical Center (2008), Pulmonary/Critical Care fellowship and CF specialty training at Yale (2013). Research interests include SPLUNC1's role in regulating inflammation, sex-based immune differences in CF, and CFTR modulator responses. His lab uses cutting-edge techniques like single-cell RNAseq and CyTOF. Major contributions include identifying SPLUNC1 as a CF exacerbation biomarker and defining immune cell profiles in CF airways. Recent studies focus on phage therapy in CF infections and developing predictive models for CF exacerbations using integrated biomarkers. Collaborates widely across Yale’s CPIRT (Center for Pulmonary Injury, Inflammation, Repair & Therapeutics) and other institutions. Awards include the 2023 Carol Basbaum Scientific Recognition Award and New Haven’s Finest Award (2017). Active in teaching and mentoring fellows in pulmonary critical care medicine.

David A. Braunمشاهده پروفایل

استادیار

• Immunotherapy
• Kidney Cancer
• Tumor Microenvironment
• +۴ مورد دیگر

David A. Braun, MD, PhD, is an Assistant Professor of Medicine (Medical Oncology) at Yale School of Medicine and a member of the Center of Molecular and Cellular Oncology (CMCO) at Yale Cancer Center. He specializes in treating kidney cancers and integrates computational and experimental approaches to advance immunotherapy for renal cell carcinoma. His research focuses on tumor genetics, immune microenvironment dynamics, and T cell-antigen interactions to develop precision therapies. Education & Training: MD: Icahn School of Medicine at Mount Sinai (2013) PhD: New York University (Computational Biology, 2012) Residency: Brigham and Women’s Hospital (2015) Fellowship: Dana-Farber Cancer Institute (2019) Research Interests: Mechanisms of immune therapy response/resistance in kidney cancer Single-cell proteogenomics of tumor-immune interactions Identification of tumor antigens and TCR-peptide-MHC interactions Awards: R37 MERIT Award (NIH/NCI, 2023) Idea Development Award (2023) Young Physician-Scientist Award (ASCI, 2023) Lab & Collaborations: The BraunLab develops patient-derived models and spatial profiling tools to study tumor immunity. Collaborators include Michael Hurwitz, Talal El Zarif, and Sidi Chen (CRI CLIP Awardee co-recipient).

Kevin C. Barryمشاهده پروفایل

استادیار

• Cancer Immunology
• Immunotherapy
• Innate Immunity
• +۵ مورد دیگر

Kevin C. Barry, PhD, is an Assistant Professor in the Public Health Sciences Division at Fred Hutchinson Cancer Center. He holds affiliate appointments in the Department of Immunology at the University of Washington and is a member of the Immunotherapy Integrated Research Center (IIRC) and Molecular & Cellular Biology Program. His research focuses on innate immune responses to cancer. Education includes: Postdoctoral Fellowship, University of California, San Francisco (2015-2019) PhD in Molecular and Cell Biology, University of California, Berkeley (2009-2015) BS in Biochemistry, University of Washington (2003-2007) Dr. Barry investigates how natural killer (NK) cells and dendritic cells regulate immune responses to cancer, particularly in melanoma and fibrolamellar carcinoma. His lab discovered an NK-dendritic cell axis that predicts immunotherapy response and survival in melanoma patients. Current research uses intravital imaging, single-cell RNAseq, and human tumor profiling to develop novel immunotherapies targeting innate immune pathways. Publications consistently focus on tumor immunology, exploring: (1) Mechanisms of immunosuppression in tumor microenvironments; (2) Biomarkers for immunotherapy response; (3) NK-dendritic cell interactions; and (4) Rare cancers like fibrolamellar carcinoma. Recent work emphasizes spatial biology and combination therapies. Awards and grants: Young Investigator Award, Melanoma Research Alliance (2023) Research Scholar Grant, American Cancer Society (2023) Dr. Barry leads an active lab with 2 PhD students, 1 postdoctoral researcher, and technical staff. The team collaborates with clinicians and uses murine cancer models, human immunology, and computational approaches. Current projects investigate hypoxia's role in NK cell function and CXCR4/PD-1 combination therapy for liver cancer.

• Insect Immunity
• Serine Protease Cascades
• Vector-Borne Disease Control
• +۶ مورد دیگر

Haobo Jiang is a Regents Professor in the Department of Entomology & Plant Pathology at Oklahoma State University. His research focuses on insect immunity, particularly the molecular mechanisms of immune responses in Manduca sexta and other insect models. He investigates serine protease cascades, pathogen recognition, and immune signaling pathways, with applications in vector-borne disease control and agricultural pest management. Education: PhD in Biochemistry, Kansas State University (1994) BSc in Chemistry, East China University of Science and Technology (1985) Postdoctoral Training in Insect Immunobiochemistry at Kansas State University (1995–2000) Teaching: ENTO/PLP 5623: Advanced Biotechnology Methods ENTO 5833: Insect Molecular Biology ENTO 5003: Insect Biochemistry Research Interests: Jiang's lab explores extracellular serine protease networks, pathogen recognition proteins, and immune signaling in insects. They use biochemical, molecular, and genomic approaches to study defense mechanisms in holometabolous insects, with recent work on single-cell RNAseq analysis of cellular immune responses. Collaborations include structural biology studies of immune proteins via X-ray crystallography and NMR spectroscopy. Grants & Funding: NIH Grant: 'The immune serine protease pathways in Anopheles gambiae' (2023–2025) NIFA Grant: 'Function and regulation of two key serine proteases in insect immunity' (2018–2024) Labs & Teams: His lab specializes in proteomics, transcriptomics, and recombinant protein expression. Techniques include hemolymph protein analysis, genome annotation, and structural biology collaborations.

• Genetic Epidemiology
• Neurological Disorders
• Sickle Cell Disease
• +۲ مورد دیگر

Allison Ashley-Koch is Professor in the Department of Medicine at Duke University. Her research employs multi-omics approaches to investigate genetic and epigenetic factors contributing to neurological disorders and sickle cell disease complications. Primary research foci include: Genetic epidemiology of neural tube defects and PTSD Sickle cell disease modifiers and complications Epigenetic mechanisms in aging and disease Large-scale genomic studies (GWAS, WGS) Recent work identifies de novo mutations in meningomyelocele, African ancestry-specific BMI variants, and epigenetic biomarkers of accelerated aging in sickle cell disease. Clinical translational research includes trials for sickle cell leg ulcers and proteomic analyses of disease complications. She leads analyses in major consortia including the Million Veteran Program, applying advanced statistical genetics methods to identify disease mechanisms.

Ala Altaieمشاهده پروفایل

پژوهشگر ارشد

• Regenerative Medicine
• Orthopedics
• Stem Cell Biology
• +۴ مورد دیگر

Dr. Ala Altaie is a Research Fellow in the School of Medicine at the University of Leeds, specializing in regenerative medicine and musculoskeletal tissue repair. His primary focus is on leveraging minimally manipulated mesenchymal stem cells (MSCs) for improving cartilage, bone, and soft tissue repair in joints. He investigates the role of resident stem cells in natural repair processes and their manipulation using novel devices, particularly through the Aura trial (NCT02696876) and intraoperative stem cell mobilization techniques. His work emphasizes the interplay between stem cell function, their microenvironment, and clinical outcomes. Research interests include cytokine signaling in enthesis (bone-tendon/ligament interface) biology, with studies on IL-17, TNF, and IL-23 pathways. He explores how these molecules affect MSC differentiation and tissue homeostasis, contributing to spondyloarthritis pathogenesis research. His device-based approaches aim to achieve one-stage surgical procedures for cartilage repair by mechanically releasing synovial MSCs with autologous platelet concentrate, eliminating the need for in vitro expansion. Professional affiliations include the International Society for Cell Therapy (ISCT) Early Stage Professionals Committee. Collaborations involve the Leeds Institute of Rheumatic and Musculoskeletal Medicine and the Regenerative Medicine Group. His work spans from basic science (e.g., single-cell RNAseq analysis of enthesis MSCs) to translational research (e.g., synovial fluid biomarker studies for cartilage repair outcomes). Key contributions include demonstrating the role of CD39/CD73 adenosine pathways in enthesis immunoregulation and identifying monocyte subsets as IL-23 producers at entheses. Current efforts focus on optimizing MSC mobilization devices and understanding cytokine modulation of MSC functions in musculoskeletal diseases.