معرفی
Clemente Britto-Leon, MD is an Associate Professor in the Department of Pulmonary, Critical Care & Sleep Medicine at Yale School of Medicine. He specializes in cystic fibrosis (CF) and pulmonary critical care, with a focus on airway innate immunity and host-pathogen interactions. He leads the Adult Cystic Fibrosis Program and directs the Pulmonary and Critical Medicine Fellowship Training Program. His research combines mechanistic studies of airway proteins like SPLUNC1 with translational work on CF exacerbations and biomarker discovery.
Education: MD from Universidad Central de Venezuela (2002), Internal Medicine residency at Albert Einstein Medical Center (2008), Pulmonary/Critical Care fellowship and CF specialty training at Yale (2013).
Research interests include SPLUNC1's role in regulating inflammation, sex-based immune differences in CF, and CFTR modulator responses. His lab uses cutting-edge techniques like single-cell RNAseq and CyTOF. Major contributions include identifying SPLUNC1 as a CF exacerbation biomarker and defining immune cell profiles in CF airways.
Recent studies focus on phage therapy in CF infections and developing predictive models for CF exacerbations using integrated biomarkers. Collaborates widely across Yale’s CPIRT (Center for Pulmonary Injury, Inflammation, Repair & Therapeutics) and other institutions.
Awards include the 2023 Carol Basbaum Scientific Recognition Award and New Haven’s Finest Award (2017). Active in teaching and mentoring fellows in pulmonary critical care medicine.