معرفی
Emanuela Bruscia is an Associate Professor of Pediatrics (Respiratory) at Yale School of Medicine, leading the Bruscia Lab within the Division of Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine. Her research focuses on the role of CFTR mutations in immune dysfunction, particularly in macrophages and monocytes, and developing therapies to address lung inflammation and tissue repair in cystic fibrosis (CF).
- Education: PhD in Biochemistry and Molecular Genetics (2002) from University of Tor Vergata, Rome, Italy
The lab investigates how CFTR deficiency affects immune cell behavior, using CF mouse models, patient specimens, and advanced cellular techniques. Key collaborations include the Yale Combined Program in the Biological and Biomedical Sciences, Yale Stem Cell Center, and the CF Center at Yale New Haven Hospital.
Recent publications demonstrate her focus on monocyte/macrophage adaptation in inflamed lungs, CFTR-modulator therapies, and innovative approaches like electrochemiluminescence CFTR immunoassays and mRNA nanoparticle delivery. Her work bridges pulmonary immunology and hematopoietic stem cell biology to identify mechanism-based therapeutic targets.