Diane Krause

Diane Krause, MD, PhD, is Professor of Laboratory Medicine, Pathology, and Cell Biology at Yale University, where she serves as Associate Director of the Yale Stem Cell Center, Director of the Clinical Cell Processing Laboratory, and Medical Director of the Advanced Cell Therapy Laboratory. She also holds the position of Vice Chair for Research Affairs in Laboratory Medicine. With over two decades of experience in cell transplant therapies, she oversees the development of immunotherapies for cancer patients at Yale Cancer Center.

Education:

• Sc.B. in Biology, Brown University
• MD and PhD, University of Pennsylvania
• Residency in Clinical Pathology, University of Pennsylvania
• Post-doctoral studies, Johns Hopkins University

Her research focuses on molecular mechanisms regulating hematopoiesis and leukemogenesis, using primary cells and stem cell models to study:

• RBM15/MKL1 roles in acute megakaryoblastic leukemia
• Hematopoietic stem cell fate specification
• Pluripotent stem cell differentiation for parathyroid therapies
• Monocyte adaptation in cystic fibrosis lung inflammation

Her work bridges basic science and clinical applications in cell therapy.

Publication trends emphasize hematopoiesis, leukemogenesis, stem cell differentiation, and immune responses in cystic fibrosis, with recent focus on m6A RNA methylation, RUNX1 phosphorylation, and single-cell transcriptomics of hematopoietic progenitors.

Awards:

• Member, Connecticut Academy of Science and Engineering (2007)
• Champion of Advocacy Award, American Society of Hematology (2006)

She leads the Krause Lab at Yale Stem Cell Center, focusing on hematopoietic stem cells and leukemogenesis. Her team collaborates extensively across Yale's immunology and cancer research programs. Current projects include developing CAR-T cell therapies and studying hematopoietic defects in cystic fibrosis models.