معرفی
Shangqin Guo is an Associate Professor in the Department of Cell Biology at Yale School of Medicine. Dr. Guo holds multiple appointments across Yale University, including in the Genomics, Genetics, and Epigenetics program, the Molecular Cell Biology, Genetics and Development program, Yale Cancer Center, Yale Combined Program in the Biological and Biomedical Sciences (BBS), Yale Stem Cell Center, Yale Ventures, and the Yale Cooperative Center of Excellence in Hematology (YCCEH).
- PhD from Boston University (2005)
Dr. Guo's research focuses on fundamental mechanisms of cell biology with particular emphasis on cellular reprogramming, hematopoietic stem cells, and experimental leukemia. Their work explores how cell cycle dynamics, mechanical signals, and transcriptional networks govern cell fate decisions and identity. A significant portion of their research investigates the molecular basis of cell fate plasticity and how signaling dynamics are incorporated into cellular decision-making processes.
The research publications reveal a consistent focus on the intersection of cell cycle regulation, stem cell biology, and hematopoiesis. Dr. Guo has developed innovative tools like fluorescent cell cycle timers to characterize cellular differentiation processes, particularly in erythropoiesis. Their work spans from basic mechanisms of cellular reprogramming to translational applications in understanding leukemogenesis and blood cell development.
- Director's New Innovator Award (DP2) (2016)
- Charles H. Hood Foundation Child Health Research Award (2016)
- Gilead Sciences Research Scholar in Hematology/oncology (2015)
- Yale Center for Clinical Investigation Scholar (2014)
- Stem Cells Young Investigator Award (2014)
Dr. Guo maintains an active research program with numerous collaborations across Yale, particularly with researchers in stem cell biology, hematology, and cancer research. Their laboratory has received significant grant support including NIH Director's New Innovator Award, demonstrating the innovative nature of their research. The Guo lab actively participates in training through the Yale Combined Program in the Biological and Biomedical Sciences and other Yale training programs.
The Guo laboratory investigates mechanisms of cellular reprogramming, malignant transformation, and hematopoiesis. Their research integrates molecular, cellular, and imaging approaches to understand how cells make fate decisions. The lab has developed specialized tools for analyzing cell cycle dynamics and has made significant contributions to understanding how mechanical signals and transcriptional networks maintain cellular identity.
