معرفی
Alayna E. Loiselle, Ph.D., is a Professor in the Department of Orthopaedics and holds joint appointments in Biomedical Engineering and Pathology & Laboratory Medicine at the University of Rochester School of Medicine and Dentistry (SMD). She leads the Musculoskeletal and Soft Tissue Fibrosis and Regeneration Lab, focusing on tendon healing mechanisms, fibrosis, and aging-related degeneration. Her work integrates molecular, cellular, and biomechanical approaches to identify therapeutic targets for tendon injuries. Dr. Loiselle's research has been recognized with awards such as the 2022 Kappa Delta Young Investigator Award and the Goldner Pioneer Award (2014).
Education includes a PhD from the University of Rochester School of Medicine & Dentistry (2009), a BS in Biology from Niagara University (2004), and postdoctoral training at Penn State College of Medicine (2013). Her lab investigates cellular lineages (e.g., Scleraxis/S100a4) driving fibrotic responses, age-related tendon dysfunction, and diabetes-induced healing impairments. Recent studies highlight macrophage-myofibroblast interactions and spatial transcriptomics in tendon healing.
Key projects include tendon regeneration strategies, lifespan maintenance of tendon structure, and soft tissue fibrosis mechanisms. Dr. Loiselle advises graduate students like Katherine Best and Jess Ackerman, and collaborates with institutions like the Center for Musculoskeletal Research. Her lab actively seeks candidates for PhD and postdoctoral positions in musculoskeletal biology.
Scientific contributions span over 50 peer-reviewed articles, including work on NF-κB signaling in tendon fibrosis and partial reprogramming to combat aging-related degeneration. Grants support investigations into biologic factors in tendon healing and translational therapies. Lab affiliations include the BME PhD Program and Cell Biology of Disease PhD Program at URMC.
