جست‌وجوی استاد و پژوهشگر

• Cell Biology
• Immunology
• Biophysics
• +۳ مورد دیگر

Pablo J. Sáez is a researcher at the University of Hamburg's Medical School, affiliated with the Department of Cell Biology and Immunology. His work focuses on cellular mechanisms of migration, signaling, and structural dynamics in immune and kidney-related cells. He explores processes like dendritic cell migration, podocyte dysfunction in nephropathy, and the role of calcium channels in cellular behavior. His research integrates biophysical and immunological approaches to understand how cell shape, cytoskeletal dynamics, and microenvironment interactions regulate immune responses and disease progression. Notable contributions include studies on membrane blebbing, SPARC-driven tumor progression, and the development of imaging tools for cellular analysis. Key areas of investigation include: cell shape sensing, actomyosin regulation, and the role of septins in immune cell motility. His articles highlight interdisciplinary methods, combining live-cell imaging, molecular biology, and computational modeling to dissect cellular decision-making processes during migration and disease. Scientific achievements include foundational work on exopher-formation in kidney disease and guidelines for functional assays in dendritic cells. His research bridges basic science and clinical applications, aiming to uncover therapeutic targets in immune and renal disorders.

Simon Scheuringمشاهده پروفایل

استاد

• Membranes and Membrane Proteins
• Molecular and Structural Biophysics
• Atomic Force Microscopy (AFM)
• +۲ مورد دیگر

Simon Scheuring, Ph.D., is a Professor of Physiology and Biophysics at Weill Cornell Medical College, Cornell University, with a primary appointment in Anesthesiology. His research focuses on membrane and membrane protein biophysics, structural biology, and single-molecule imaging techniques. Techniques: Atomic Force Microscopy (AFM), Cryo-Electron Microscopy (Cryo-EM), Single-Molecule Spectroscopy Member of: Physiology, Biophysics and Systems Biology (PBSB) Lab Website: bio-afm-lab.com Dr. Scheuring studies plasma membrane structure and dynamics, emphasizing membrane protein organization and function in eukaryotic cells. His work addresses technical challenges in high-resolution imaging of membrane systems using advanced AFM methodologies, including high-speed AFM for physiological environment imaging. His lab aims to overcome bottlenecks in understanding conformational changes, protein interactions, and supramolecular complexes within native biomembranes. Recent publications highlight his team's innovations in AFM-based structural biology, membrane protein kinetics, and membrane remodeling mechanisms. The lab develops tools like standardized AFM file formats and investigates medically relevant proteins, including TRPV channels and ESCRT-III homologs. His lab at 1300 York Avenue (Room E-023) maintains a dedicated website ( bio-afm-lab.com ) documenting their technical and biological breakthroughs in atomic force microscopy applications.

• Cell Biology
• Cancer Metastasis
• Super-resolution Microscopy
• +۴ مورد دیگر

Guillaume Jacquemet is an Associate Professor (tenure track) at the University of Turku's Faculty of Science and Engineering, Department of Biochemistry and Cell Biology. He is affiliated with the InFLAMES Flagship (Innovation Ecosystem based on the Immune System) Solutions for Health. His research focuses on cell biology, microscopy techniques, and computational biology, with a focus on cancer metastasis mechanisms and imaging technologies. Jacquemet leads or co-leads several projects, including the PanMet initiative on pancreatic cancer metastasis mechanisms and the CellMech Center of Excellence in Cellular Mechanostasis. He develops software tools like CellTracksColab and DL4MicEverywhere, advancing reproducible microscopy analysis. His research integrates live-cell imaging, super-resolution microscopy, and AI to study cell migration, tumor invasion, and immune responses. Key projects include investigating CD44-HA interactions in cancer cell arrest and SHANK3's role in KRAS-mutant cancers. Jacquemet collaborates internationally and organizes events like Forskarnatten to promote science communication. His work contributes to UN Sustainable Development Goals related to health and innovation. Publications highlight advancements in phototoxicity reduction via AI, quantitative tracking platforms, and molecular complex analysis. His datasets and open-source tools, such as ZeroCostDL4Mic, democratize bioimage analysis. Jacquemet's research bridges experimental and computational biology, addressing challenges in live imaging and cellular mechanics.

• Cancer Biology
• Hematopoietic Malignancies
• Extracellular Vesicles
• +۶ مورد دیگر

Margaret McGee is an Associate Professor at the School of Biomolecular and Biomedical Science , University College Dublin , with a research focus on cancer biology and extracellular vesicle signaling. Her work spans hematological malignancies, bone marrow microenvironment interactions, and mitotic regulatory mechanisms. She coordinates major modules including Genetic Basis of Disease and Regulation of Gene Expression . BSc University of Reading Dip Applied Science Dublin Institute of Technology PhD Biochemistry Trinity College Dublin Her research explores extracellular vesicle-mediated communication in cancer progression, cyclophilin A's role in mitotic exit, and preclinical biotherapeutic development. Current collaborations with Vejle Hospital Denmark and Mater Hospital Dublin investigate EV-based liquid biopsies for therapy response prediction. Notably, she co-authored the foundational MISEV2023 guidelines for extracellular vesicle research. Scientific contributions include: Wellcome Trust ISSF Mid Career Fellow (2017) Conway Institute Fellow (2007) IRCSET Fellowship (2003) She leads the EU Twinflag consortium for EV-based biomarker development in joint disorders and chairs the SBBS Research, Innovation and Impact Committee (2020-2024). Her lab has trained numerous researchers who now hold prominent positions in academia and industry.

Drew Bridgesمشاهده پروفایل

استادیار

• Bacterial Biofilms
• Microbial Developmental Biology
• Quorum Sensing
• +۳ مورد دیگر

Drew Bridges is an Assistant Professor in the Department of Biological Sciences at Carnegie Mellon University, within the Mellon College of Science. His research focuses on understanding how bacteria make developmental decisions based on extracellular sensory information, with a specific emphasis on the formation and disassembly of bacterial biofilms in Vibrio cholerae . The Bridges Lab employs interdisciplinary approaches, including advanced imaging, genetics, biochemistry, and biophysics, to unravel the molecular mechanisms underlying biofilm dispersal and bacterial lifestyle transitions. Bridges earned a Ph.D. from Dartmouth College and completed a postdoctoral appointment at Princeton University. His work has pioneered novel imaging techniques to study biofilm dynamics and has revealed key insights into signaling pathways, matrix digestion, and motility components that control biofilm dispersal. The lab aims to uncover general principles of microbial behavior and apply these findings to combat infections and inform strategies for manipulating bacterial communities. Research interests extend to exploring how bacteria regulate lifestyle changes across scales—from molecular signaling to community-level behaviors. Future work seeks to expand studies to other microorganisms, identifying species-specific versus universal mechanisms. The lab also prioritizes fostering an inclusive, collaborative environment for trainees, emphasizing scientific rigor and innovation. Recent publications highlight advancements in understanding two-component signaling systems, quorum sensing, and biofilm dispersal mechanisms in Vibrio cholerae . These studies underscore the lab's focus on integrating experimental and theoretical approaches to address complex biological questions. Lab activities include managing a dynamic research group at the historic Mellon Institute building, established in 2022. Collaborative projects and grants are central to advancing their research, though specific grant details are not detailed in the provided texts. The lab website provides further information on ongoing studies and opportunities for trainees.

Kazuhito Toyookaمشاهده پروفایل

دانشیار

• Neurodevelopmental Disorders
• Gene Therapy
• Neurobiology
• +۷ مورد دیگر

Kazuhito Toyooka is an Associate Professor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine. His research focuses on translational studies for neurological disorders, including autism spectrum disorder (ASD), epilepsy, and Parkinson's disease (PD). He employs peptide therapy, CRISPR gene editing, and 14-3-3 modifiers to develop treatments using mouse models and patient-derived hiPSCs. His lab investigates gene functions in axon/dendrite growth, synapse formation, and neurobehavioral outcomes. Education: PhD in Immunology from Osaka University, Japan. Languages spoken: Japanese. Research Themes: Peptide therapy and CRISPR for ASD and PD 17p13.3 microdeletion/duplication syndromes 14-3-3 protein roles in epilepsy and neurodegeneration ADNP protein’s role in neuronal development Key Publications (2024-2018): Focus on neuronal morphogenesis methods, ADNP-14-3-3 interactions, and 14-3-3 signaling in neurodevelopmental disorders. Lab Personnel: Includes undergraduate/graduate students, MD/PhD trainees, and postdoctoral fellows working on ASD, PD, and 14-3-3 protein research.

Elisabeth Busch-Nentwichمشاهده پروفایل

مدرس ارشد

• Gene Regulatory Networks
• Developmental Biology
• Zebrafish Models
• +۳ مورد دیگر

Dr. Elisabeth Busch-Nentwich is a Senior Lecturer in Organismal Biology at Queen Mary University of London, affiliated with the School of Biological and Behavioural Sciences. Her research focuses on gene regulatory responses to challenges such as genetic mutations, chromatin disruption, and infection, primarily using zebrafish as a model system. Her lab investigates molecular mechanisms underlying disease susceptibility, lipid metabolism, and developmental processes. Key research areas include understanding how genetic mutations impact cellular functions and host-pathogen interactions. She has supervised PhD students Pavol Kramár and Tian Qiu, and postdoctoral researchers Ian Sealy and Richard White. Recent work highlights her lab’s contributions to studying Shigella infection susceptibility, tumor suppression mechanisms in melanoma, and the role of selenoproteins in vascular disorders. Her publications reflect a strong emphasis on translational research, bridging fundamental biology with clinical implications. Dr. Busch-Nentwich’s lab, based in London, employs cutting-edge techniques such as single-cell RNA sequencing and CRISPR-mediated mutagenesis to dissect complex biological processes. Her work has implications for understanding metabolic diseases, genetic disorders, and infectious diseases.

Stefan Raunserمشاهده پروفایل

استاد

• Structural Biochemistry
• Molecular Biology
• Cryo-Electron Microscopy
• +۹ مورد دیگر

Prof. Dr. Stefan Raunser is Director of the Department of Structural Biochemistry at the Max Planck Institute of Molecular Physiology in Dortmund, Germany. He holds concurrent professorships at the University of Duisburg-Essen (Honorary Professor, 2015–now) and Technical University Dortmund (Adjunct Professor, 2015–now). PhD in Biochemistry, University of Frankfurt (2001–2004) Diploma in Biology, University of Mainz (1995–2000) His research focuses on structural and functional analysis of macromolecular complexes governing cellular processes, particularly muscle contraction (actin-myosin-tropomyosin interactions) and bacterial toxin mechanisms (Tc toxins, Type VI secretion systems). He pioneered cryo-EM and cryo-ET applications for high-resolution imaging of sarcomeres, toxin complexes, and membrane proteins like the ryanodine receptor. His department also developed SPHIRE , a user-friendly cryo-EM image processing suite. Scientific awards include the ERC Synergy Grant (2020) , ERC Consolidator Grant (2014) , and Einstein Foundation Berlin Professorship (2013) . He has advised numerous PhD and Master’s students, including Elmar Behrmann , Shyamal Mosalaganti , and Zhexin Wang , and led collaborations on projects involving Cryo-EM of TRPC4 ion channels and septin complex regulation .

Martin Gullbergمشاهده پروفایل

استاد

• Molecular Biology
• Cell Biology
• Microtubule Dynamics
• +۵ مورد دیگر

Martin Gullberg is a Professor at the Department of Molecular Biology at Umeå University, Sweden. His research focuses on molecular mechanisms governing cellular processes such as microtubule dynamics, septin complex assembly, and their roles in cell polarization and disease. He has published extensively in leading journals including Molecular Biology of the Cell , Experimental Cell Research , and EMBO J . His work spans subfields like: Septin-Microtubule Interactions Chromosomal Instability in Leukemia Signal Transduction in T Cell Responses Bacterial Protein Secretion Systems The most recent publications highlight his contributions to understanding the Swedish pandemic response policies (2023) and Vibrio cholerae pathogenesis (2020), alongside foundational work on septins and tubulin regulation (2014–2004).

Denise J. Montellمشاهده پروفایل

استاد

• Cell Biology
• Cancer Biology
• Cell Motility
• +۳ مورد دیگر

Denise J. Montell is the Duggan Professor and Distinguished Professor in the Department of Molecular, Cellular, and Developmental Biology at the University of California, Santa Barbara (UCSB). She leads a lab focused on cell survival (anastasis), cell motility, and understudied cellular processes like cell cannibalism. Her research integrates molecular genetics, live imaging, and computational modeling to explore mechanisms underlying cancer, neurodegeneration, and regeneration. Education: B.S. in Biochemistry & Cell Biology (UC San Diego), Ph.D. in Neuroscience (Stanford University). Postdoctoral training at the Carnegie Institution. Previously served as a full professor at Johns Hopkins University School of Medicine. Research Interests: Anastasis : Survival of cells from apoptosis, with implications for heart disease and cancer therapy resistance. Cell Motility : Mechanisms of collective cell migration in development and metastasis using Drosophila models. Cellular Behaviors : Cannibalism, stem cell longevity during diapause, and neolamination. Awards: Elected to National Academy of Sciences (2021) NIH Director’s Pioneer Award Fellowships from AAAS, ASCB Labs & Affiliations: Director of UCSB’s Center for Aging and Longevity Studies (CALS), affiliated with Molecular, Cellular, and Developmental Biology and Biomolecular Science & Engineering departments. Serves on advisory boards for the National Cancer Institute and Genetics Society of America.

Vinay Swaminathanمشاهده پروفایل

مدرس ارشد

• Cell Mechanobiology
• Cancer Microenvironment
• Quantitative Microscopy
• +۵ مورد دیگر

Vinay Swaminathan is a Senior Lecturer and Principal Investigator at Lund University, affiliated with the Wallenberg Centre for Molecular Medicine , Lund University Cancer Centre (LUCC) , and NanoLund . His research focuses on cell mechanobiology , particularly how mechanical environments regulate cellular functions in cancer progression and tissue homeostasis. Research Themes: Mechanotransduction 3D Cancer Models Integrin-Actin Dynamics Multimolecular Adhesion Structures Quantitative Microscopy Key contributions include ECM-stiffness sensing , septin regulation in focal adhesions , and pol-diSPIM microscopy . He supervises PhD students in projects related to HER2-targeted immunotherapy and lipid-mediated siRNA delivery , funded by Mrs. Berta Kamprad's Cancer Foundation . His work aligns with UN Sustainable Development Goals for health and environmental innovation .

Elias T Spiliotisمشاهده پروفایل

استاد

• Spatial Cell Biology
• Neuronal Morphogenesis
• Cancer Migration and Invasion
• +۵ مورد دیگر

Elias T Spiliotis serves as Professor of Cell Biology within the Department of Cell Biology at the University of Virginia School of Medicine. His research program investigates spatial organization mechanisms in neurons and epithelia with direct implications for neurological disorders and cancer metastasis. Education: BS from Boston College PhD from Johns Hopkins University Postdoctoral training at Stanford University Dr. Spiliotis's research centers on septin GTPases as master regulators of cellular asymmetry. Key initiatives include: (1) Decoding septin-mediated 'traffic codes' for motor proteins in neuronal transport; (2) Elucidating cytoskeletal crosstalk in neurite formation relevant to autism and schizophrenia; (3) Investigating septin-driven nuclear deformation mechanisms in cancer cell invasion. His laboratory employs super-resolution microscopy, gene targeting, and in vitro reconstitution to dissect these processes at molecular resolution. Analysis of his 15 most recent publications (2010-2024) reveals consistent focus on septin-cytoskeleton interactions across neuronal development, cancer metastasis, and fundamental membrane trafficking. Dominant trends include mechanistic studies of septin-motor protein regulation (60% of recent work) and disease modeling in neurodevelopmental disorders (25%) and breast cancer (15%). Scientific Awards: No awards specified in source materials Advising and grants information was not documented in the provided texts. The Spiliotis Lab (spiliotislab.org) maintains active research in spatial cell biology, utilizing advanced imaging and biochemical approaches to study septin functions in cellular organization and disease.

• Molecular Biotechnology
• Neurodegenerative Diseases
• Protein Aggregation
• +۷ مورد دیگر

Joris Winderickx is a Full Professor at the Faculty of Sciences, KU Leuven, where he leads research in the Department of Molecular Biotechnology of Plants and Microorganisms. He is also a member of the KU Leuven Brain Institute, contributing to interdisciplinary neuroscience research. His work bridges molecular biology, cell signaling, and neurodegenerative disease mechanisms. Professor Winderickx's research focuses on understanding fundamental cellular processes using yeast as a model system, with particular emphasis on neurodegenerative diseases. His laboratory investigates protein aggregation phenomena related to Alzheimer's and Parkinson's diseases, studying how proteins like Tau and α-synuclein affect cellular homeostasis. His team examines critical cellular mechanisms including calcium signaling, pH regulation, organelle contact sites, and nutrient-sensing pathways. The research has significant implications for understanding the molecular basis of neurodegeneration and identifying potential therapeutic targets. His recent publications demonstrate a strong focus on the intersection of cellular physiology and neurodegenerative disease mechanisms. The work shows consistent emphasis on using yeast models to unravel complex protein aggregation phenomena, with particular attention to how disruptions in calcium homeostasis, organelle communication, and signaling pathways contribute to neurodegeneration. The research trajectory indicates increasing sophistication in modeling human disease processes in simple eukaryotic systems. Professor Winderickx actively supervises graduate students and leads multiple research projects funded by competitive grants. His current projects include studies on Tau protein conformation and oligomerization for Alzheimer's disease diagnostics and therapeutics, investigation of membrane contacts in α-synuclein toxicity for Parkinson's disease, and research on calcium and pH homeostasis in yeast models. His laboratory serves as an important hub for interdisciplinary research connecting molecular biology, neuroscience, and biotechnology.

Joris de Witمشاهده پروفایل

استاد

• Molecular Neuroscience
• Synapse Biology
• Neurodegenerative Diseases
• +۵ مورد دیگر

Joris de Wit is a Professor at KU Leuven's Department of Neuroscience and heads the Laboratory for Synapse Biology at the VIB-KU Leuven Center for Brain & Disease Research. His work focuses on molecular mechanisms of synaptic connectivity, with translational applications in Alzheimer's disease and autism. Supported by ERC and FWO grants, he leads an international team of researchers and trains students through Erasmus programs. Education : PhD from VU University Amsterdam (2004), postdoctoral training at VU University (2004-2006) and UCSD (2006-2010) Research spans cell-surface interactions , synaptic proteomics , and neurodegenerative mechanisms . Key methodologies include transsynaptic mapping, CRISPR-based screens, and advanced electrophysiology units. His 2025 Developmental Cell study reveals GPR158-PLCXD2's role in spine maturation, while 2023 Cell work identifies LRRC37B in human cortical excitability. Scientific Awards : ERC Starting Grant, FWO Odysseus Grant Mentored over 20 PhD and Master's students, including multiple award winners. Institutional roles include Deputy Scientific Director (2018-present) overseeing technology units in FACS, neuroengineering, and proteomics. Organized international workshops like the Lowlands Synapse Symposium.

Rebecca C. Adikesمشاهده پروفایل

استادیار

• Cytoskeleton
• Cell Migration
• Cell Biology
• +۲ مورد دیگر

Dr. Rebecca C. Adikes is an Assistant Professor at Siena University (formerly Siena College), where she joined in Fall 2021 as a Leading Edge New Faculty Fellow conducting research on cytoskeletal dynamics and cell migration. Dr. Adikes' educational background includes: Ph.D. in Molecular, Cellular & Developmental Biology, University of North Carolina at Chapel Hill B.A. in Biochemistry, Mount Holyoke College Her research focuses on understanding cytoskeletal regulation from atomic to organismal levels, specifically how actin cytoskeleton governs cell migration and adhesion in vivo using C. elegans. The lab investigates cellular rearrangement of structural components like actin in response to environmental signals to enable navigation through complex 3D spaces. Dr. Adikes has received: Fulbright Research Fellow (2011-2012) Leading Edge New Faculty Fellow Mentoring undergraduate researchers through CURCA-funded projects, her lab has executed diverse studies including: Nuclear Hormone Receptors in planaria Actin binding proteins in myoblast development Septins in C. elegans ROS during planaria regeneration Cytoskeletal organization in cell migration/differentiation Established in 2021, the Adikes Lab operates as a dynamic undergraduate research team with active collaborations at Columbia University Irving Medical Center and Marine Biological Laboratory.