Pablo J. Sáez

Pablo J. Sáez is a researcher at the University of Hamburg's Medical School, affiliated with the Department of Cell Biology and Immunology. His work focuses on cellular mechanisms of migration, signaling, and structural dynamics in immune and kidney-related cells. He explores processes like dendritic cell migration, podocyte dysfunction in nephropathy, and the role of calcium channels in cellular behavior.

His research integrates biophysical and immunological approaches to understand how cell shape, cytoskeletal dynamics, and microenvironment interactions regulate immune responses and disease progression. Notable contributions include studies on membrane blebbing, SPARC-driven tumor progression, and the development of imaging tools for cellular analysis.

Key areas of investigation include: cell shape sensing, actomyosin regulation, and the role of septins in immune cell motility. His articles highlight interdisciplinary methods, combining live-cell imaging, molecular biology, and computational modeling to dissect cellular decision-making processes during migration and disease.

Scientific achievements include foundational work on exopher-formation in kidney disease and guidelines for functional assays in dendritic cells. His research bridges basic science and clinical applications, aiming to uncover therapeutic targets in immune and renal disorders.