جستجوی استاد راهنمای دانشگاهی

Tobias Dick serves as Professor and Head of the Division of Redox Regulation at the German Cancer Research Center (DKFZ) in Heidelberg, maintaining a primary affiliation with Heidelberg University's Faculty of Biosciences. His leadership spans molecular switch research within the SFB/TRR186 consortium focusing on spatio-temporal control of cellular signal transmission. Academic Background: PhD in Biochemistry, Freie Universität Berlin (1997, summa cum laude) Habilitation in Biochemistry, Heidelberg University (2009) Diploma thesis at German Cancer Research Center (1994) Study program in Biochemistry, Freie Universität Berlin (1989-1994) Research Focus: Dick pioneers investigations into thiol-based redox switches governing cellular signal transduction. His work establishes fundamental mechanisms of peroxiredoxin-mediated hydrogen peroxide signaling, protein persulfidation dynamics, and sulfur-based radical scavenging systems. Key contributions include developing real-time imaging probes for redox species and elucidating redox relays connecting peroxiredoxins to transcription factors like STAT3. Current research explores hydropersulfide protection against ferroptosis and metabolic adaptation through redox-sensitive enzymes. Publication Trends: Over 15 years of high-impact publications reveal an evolutionary trajectory from foundational redox imaging techniques (2008-2011) to sophisticated molecular mechanism studies (2013-2020), culminating in recent breakthroughs on sulfur signaling in cell death pathways (2023). His work consistently appears in premier journals like Nature Chemical Biology , demonstrating sustained innovation in redox biology methodology and conceptual frameworks. Scientific Recognition: ERC Advanced Grant (2017) Society for Free Radical Research Europe Basic Science Award (2017) Chica- and Heinz-Schaller-Award for young scientists (2009) Marie Curie Excellence Grant (2004) DFG Postdoctoral Fellowship (1998-2000) Studienstiftung des Deutschen Volkes Scholarship (1989-1994) Leadership & Mentorship: As founding vice-coordinator of DFG priority program SPP1710 (2014-present) and GBM Redox Biology Study Group (2011-2017), Dick shapes national research agendas. His division at DKFZ mentors next-generation scientists through ERC and DFG-funded projects, with trainees contributing to landmark publications on redox switches and cellular physiology. Research Infrastructure: The Division of Redox Regulation operates within DKFZ's state-of-the-art facilities, collaborating extensively through the SFB/TRR186 consortium. This environment enables cutting-edge investigations into redox-controlled cellular processes using advanced biochemical, imaging, and computational approaches.

• Redox Biology
• Signal Transduction
• Cellular Physiology
• +۳ مورد دیگر

Gilles Peslherbe is a Professor at Concordia University, cross-appointed in the departments of Chemistry and Biochemistry , Physics , and Chemical and Materials Engineering . He leads the Centre for Research in Molecular Modeling (CERMM) and supervises graduate students in programs spanning Chemical Engineering, Chemistry, Physics, and Nanoscience. PhD in Physical Chemistry with Minor in Computer Engineering (Wayne State University, USA) Diplôme d'Ingénieur Chimiste (Ecole Supérieure de Chimie Industrielle de Lyon, France) His research integrates computational chemistry , quantum mechanics , and machine learning to model chemical processes in extreme conditions, drug delivery systems, and environmental impact assessments. Collaborative projects include studies on spin catalysis , nanostructured materials , and RNA structure fundamentals . Recent publications highlight applications of artificial intelligence in therapeutics development , density-functional theory in nanomaterials , and ultrasfast spectroscopy in electron solvation . His work bridges quantum computing and biological simulations . Teaching includes courses on quantum theory , computational chemistry , and statistical mechanics . He actively seeks students for ongoing projects in chemical interactions in extreme conditions and environmental remediation .

• Computational Chemistry
• Molecular and Reaction Dynamics
• Nanomaterials and Materials Engineering
• +۸ مورد دیگر

Annarita DiLorenzo is a Professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College, where she also holds a position in the Graduate School of Medical Sciences. She leads a research laboratory focused on vascular and sphingolipid biology, with a strong emphasis on endothelial function, nitric oxide signaling, and lipid metabolism in cardiovascular disease. Her research interests center on the molecular mechanisms regulating vascular permeability, inflammation, and blood pressure. Key areas include the role of endothelial nitric oxide synthase (eNOS) and the ER protein Nogo-B in controlling endothelial barrier function and vascular tone. She investigates how sphingolipids such as ceramide and sphingosine-1-phosphate (S1P) influence vascular homeostasis, atherosclerosis, and cardiac hypertrophy. Her recent publications reveal a consistent focus on endothelial sphingolipid metabolism, particularly the balance between ceramide and S1P, and its impact on hypertension, coronary atherosclerosis, and cerebrovascular health. The work integrates molecular biology, lipid signaling, and vascular physiology, often using genetically modified mouse models to dissect pathway-specific effects. Dr. DiLorenzo's research is supported by grants from the National Institutes of Health (NIH), the American Heart Association (AHA), and the Harold S. Geneen Charitable Trust, reflecting the significance and translational potential of her work. She mentors postdoctoral researchers and collaborates extensively within the institution. Her laboratory team includes Olivia Garnier and Onorina Laura Manzo, both postdoctoral associates.

• Vascular Biology
• Endothelial Function
• Sphingolipid Metabolism
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Jorge Amich Elias is an Honorary Lecturer (Teaching & Research) at the University of Manchester, affiliated with the Division of Evolution, Infection and Genomics. His research focuses on fungal metabolism, particularly in Aspergillus fumigatus , exploring virulence traits, antifungal targets, and sulfur metabolism's role in pathogenicity. He has pioneered studies on persulfidation's impact on fungal virulence and host defense, and investigates microbial interactions in co-infections. Key projects include leadership in the Manchester Fungal Infection Group (MFIG), active since 2013, addressing Aspergillus infections. His work contributes to UN Sustainable Development Goals related to health and innovation. Research outputs span 27 articles, including recent studies on zebrafish fin regeneration and antifungal drug targets. He actively reviews for journals like Frontiers in Microbiology and participates in academic events, such as the Manchester Science Festival and invited talks on antifungal drug development.

• Fungal Metabolism
• Antifungal Targets
• Fungal Pathogenicity
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Pier Alexandre Champagne is an Assistant Professor in the Department of Chemistry and Environmental Science at New Jersey Institute of Technology (NJIT). He holds a Ph.D. in Organic Chemistry from Université Laval (2015) and a B.S. in Chemistry from the same institution (2010). His research focuses on organic synthesis, chemical biology, and catalysis, with particular emphasis on fluorine chemistry, bioorthogonal reactions, and mechanistic studies of complex organic transformations. Key areas of investigation include persulfide chemistry, carbocation equilibria, and the development of selective synthetic methodologies for drug delivery systems. Dr. Champagne's work bridges organic synthesis and biomedical applications, exploring novel strategies for controlled chemical release in living systems. His lab employs cutting-edge techniques such as computational modeling (DFT) and advanced spectroscopic methods to elucidate reaction mechanisms. Notable contributions include studies on sulfur-mediated reactions, fluorine-containing reagents, and the design of pH-responsive chiroptical materials. His research has been published in high-impact journals, with recent work emphasizing mechanistic insights into polysulfide reactivity, stereoselective synthesis of heterocyclic compounds, and bioorthogonal activation of drug prodrugs. The lab's publications reflect a strong focus on sustainability, with an emphasis on developing greener synthetic pathways and functional materials.

• Organic Chemistry
• Chemical Biology
• Catalysis
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Annarita Di Lorenzo is a Professor of Pathology and Laboratory Medicine at Weill Cornell Medical College. She has established herself as a leading researcher in vascular biology and sphingolipid metabolism, with a particular focus on endothelial function and cardiovascular diseases. Her work bridges basic science with clinical applications, aiming to understand the molecular mechanisms underlying vascular homeostasis and disease. Dr. Di Lorenzo received her M.Sc. in 2001 and Ph.D. in 2004 from the University of Naples "Federico II" in Italy. Her academic journey has led her to become a prominent figure in cardiovascular research at Weill Cornell Medicine. Dr. Di Lorenzo's research primarily focuses on sphingolipid signaling pathways in vascular biology. Her laboratory investigates how sphingolipids, particularly sphingosine-1-phosphate (S1P) and ceramide, regulate endothelial function, blood pressure, and vascular homeostasis. A significant portion of her work examines the role of Nogo proteins (particularly Nogo-B) in vascular function and disease. She has made important contributions to understanding how sphingolipid metabolism influences atherosclerosis, hypertension, and metabolic syndrome. Her research often combines molecular, cellular, and whole-animal approaches to elucidate mechanisms of vascular dysfunction and identify potential therapeutic targets. Analysis of Dr. Di Lorenzo's recent publications reveals a strong emphasis on sphingolipid metabolism in vascular function. Her work consistently explores the balance between S1P and ceramide in endothelial cells and how this balance affects vascular tone, blood pressure, and atherosclerosis. She has pioneered research on Nogo proteins in vascular biology, demonstrating their critical role in regulating sphingolipid biosynthesis. Her publications span high-impact journals in cardiovascular biology, including Circulation Research , Nature Communications , and Cell Metabolism , reflecting the significance of her contributions to the field. Principal Investigator: "Quantitative susceptibility mapping for stroke risk prediction of vulnerable carotid plaques" (2024-2025, National Institute of Neurological Disorders & Stroke) Principal Investigator: "Sphingolipid Biology of macrophage in Coronary Atherosclerosis Development and Progression" (2022-2027, National Heart, Lung, & Blood Institute) Dr. Di Lorenzo's laboratory represents a sophisticated integration of molecular biology, vascular physiology, and translational medicine, positioning her as a leader in the emerging field of vascular sphingolipid biology. Her work has important clinical implications for understanding and treating hypertension, atherosclerosis, and other cardiovascular conditions that affect millions worldwide.

• Vascular Biology
• Sphingolipid Metabolism
• Cardiovascular Research
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Professor Tatjana Hildebrandt leads the Plant Metabolic Biochemistry Lab at the Institute for Plant Sciences, University of Cologne, where she serves as Principal Investigator within the Cluster of Excellence on Plant Sciences (CEPLAS) and TRR 341 "Plant Ecological Genetics." Her research group investigates plant amino acid metabolism with particular focus on cysteine pathways, mitochondrial function, and metabolic adaptations to environmental stress. Her research program spans four main areas: (1) Amino acid metabolic pathways with emphasis on catabolic processes; (2) Metabolic plasticity during abiotic stress conditions including drought, hypoxia, and energy deficiency; (3) Metabolic interactions between plants and microbes; and (4) Amino acid sensing mechanisms including post-translational modifications like persulfidation. Her group employs biochemical, proteomic, and metabolomic approaches to unravel these complex processes. Analysis of her recent publications reveals a strong focus on cysteine metabolism, mitochondrial function during germination, and the role of amino acids in stress signaling. Her work bridges fundamental plant biochemistry with potential applications in improving crop resilience. Her research consistently appears in high-impact journals including Plant Physiology, Journal of Experimental Botany, and Trends in Biochemical Sciences. Her laboratory currently includes multiple PhD students and postdoctoral researchers working on projects related to amino acid metabolism in Arabidopsis and Lupinus albus. She actively collaborates with researchers across Europe through CEPLAS and the International Max Planck Research School (IMPRS).

• Plant Biochemistry
• Amino Acid Metabolism
• Plant Stress Response
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Lorenzo Moroni is a Full Professor in Biofabrication for Regenerative Medicine at the MERLN Institute for Technology-Inspired Regenerative Medicine of Maastricht University. He leads research in developing biofabrication technologies to generate instructive scaffolds for controlling stem cell fate in tissue engineering applications. His work bridges the gap between advanced manufacturing techniques and regenerative medicine solutions. Ph.D. (cum laude) in Tissue Regeneration from Universiteit Twente (2003-2006) M.Sc. (cum laude) in Nanoscale Science and Engineering from Chalmers tekniska högskola (1999-2002) M.Sc. in Biomedical Engineering from Politecnico di Milano (1995-2001) Professor Moroni's research focuses on the intersection of biomaterials science, stem cell biology, and advanced manufacturing techniques. His laboratory specializes in developing 3D scaffolds and biofabrication technologies for tissue engineering applications, with particular emphasis on controlling stem cell fate through engineered microenvironments. The group investigates various biomaterial systems including hydrogels, nanofibers, and composite scaffolds for applications in bone, cartilage, nerve, vascular, and kidney tissue regeneration. Recent work has expanded into computational modeling of scaffold design and multi-material bioprinting approaches that enable more complex tissue architectures. His publication record reveals a strategic evolution toward increasingly sophisticated biofabrication methodologies, with significant emphasis on melt electrowriting, multi-material bioprinting, and the development of organ-specific models. The research spans multiple tissue systems but demonstrates particular depth in vascular engineering, osteochondral regeneration, and kidney organoid development. A distinctive pattern across his recent work is the integration of computational modeling with experimental validation to optimize scaffold architecture and predict cellular responses, representing a systems approach to tissue engineering challenges. Professor Moroni has served as principal investigator for numerous collaborative research projects in regenerative medicine and maintains an active laboratory environment that fosters interdisciplinary collaboration. His research group includes specialists in biomaterials science, stem cell biology, computational modeling, and advanced manufacturing, creating a comprehensive ecosystem for tissue engineering innovation. The laboratory maintains strong partnerships with clinical researchers and industry collaborators to facilitate translational development of biofabricated constructs. The Moroni Lab at Maastricht University's MERLN Institute operates state-of-the-art facilities for biomaterials development, biofabrication, and tissue characterization. The team employs a multidisciplinary approach combining expertise in materials science, stem cell biology, biomechanics, and advanced manufacturing to address complex challenges in regenerative medicine. Current projects focus on developing next-generation biomaterial platforms that can precisely guide tissue formation and integration in vivo, with particular attention to vascularization strategies and the creation of functional organ-specific microenvironments.

• 3D scaffolds
• biomaterials
• biofabrication
• +۳ مورد دیگر

Joseph Lin is a Professor in the Department of Biology at Sonoma State University, affiliated with the College of Science, Technology, and Business. He holds a Ph.D. from the University of California, San Francisco (2003), and completed postdoctoral research at Washington University in Saint Louis. His research focuses on T cell activation mechanisms and redox biology, particularly the signaling pathways governing immune responses and autoimmune disease prevention. He teaches courses in molecular biology, immunology, and virology. Research interests include molecular and cellular biology, signal transduction, immunology, and the chemical biology of hydropersulfides. His work explores how T cells balance pathogen response and self-tolerance, with a focus on intracellular signaling pathways and redox regulation. Recent studies investigate hydropersulfides' roles in cellular protection, antioxidant defense, and redox signaling. Selected publications span topics like hydrogen sulfide biochemistry, hydropersulfide reactivity, and oxidative stress responses. His lab's findings contribute to understanding redox biology's role in health and disease. Teaching responsibilities include advanced courses such as Immunology (BIOL 480) and Molecular Virology (BIOL 383).

• Molecular Biology
• Immunology
• Signal Transduction
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Eugene G. Mueller is the Charles L. Bloch Professor of Chemistry at the University of Louisville. His research focuses on mechanistic enzymology, particularly tRNA modification and sulfur transfer mechanisms. He leads the Mueller Research Group, which investigates enzymatic catalysis and bioorganic mechanisms. Education: B.S. from University of Illinois–Urbana (1987), Ph.D. from Harvard University (1992). Research Interests: Biochemistry, Enzymology, RNA modification pathways, sulfur transfer in biosynthesis, and mechanistic enzymatic processes. His work combines structural biology, biochemistry, and chemical biology approaches. Recent publications (2006) highlight studies on pseudouridine synthase RluA, persulfide intermediates in 4-thiouridine biosynthesis, and sulfur trafficking mechanisms. These contributions advance understanding of enzymatic catalysis and RNA modification. Labs/Teams: The Mueller Research Group operates in the Belknap Research Building, with postdoctoral positions available. Contact details include 346 Belknap Research Building, Louisville, KY and phone (502) 852-5811.

• Biochemistry
• Mechanistic Enzymology
• Enzymology
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Matthew H. Sazinsky is a Professor of Chemistry at Pomona College , where he has served since 2007. His research integrates X-ray crystallography and biochemical techniques to investigate protein structure and function, with a focus on metalloenzymes and their roles in bacterial metabolism. Education: Ph.D. from Massachusetts Institute of Technology, B.S. from Haverford College His research spans three primary themes: (1) identifying determinants of metalloenzyme activity , (2) re-engineering proteins for novel functions, and (3) elucidating biochemical processes in pathogenic bacteria . Recent work explores NADH-dependent enzymes , FAD-transfer reactions , and sulfur respiration in Shewanella and Pyrococcus species. Publications reveal trends in metalloprotein structure-function relationships , redox enzyme mechanisms , and biometal interactions in disease contexts like diabetes. Collaborative projects often involve interdisciplinary approaches to enzyme engineering and bacterial physiology. Scientific Awards: Wig Distinguished Professorship Award for Excellence in Teaching (2010) Camille and Henry Dreyfus Faculty Start-Up Award (2007) Dr. Sazinsky has secured competitive grants and mentorship accolades, emphasizing hands-on undergraduate training in structural biology and biochemistry . His lab provides students with opportunities for structural and biochemical characterization of protein targets, fostering early-career research development.

• Biochemistry
• Structural Biology
• Bio-Inorganic Enzymology
• +۳ مورد دیگر

PD Dr. Arnulf Kletzin is a lecturer at Technische Universität Darmstadt, specializing in sulfur biochemistry and microbial bioenergetics. His research focuses on sulfur-oxidizing and reducing enzymes, particularly sulfur oxygenases and persulfide dioxygenases, in extremophiles such as Acidianus ambivalens and Acidithiobacillus caldus . He investigates microbial sulfur metabolism in hydrothermal environments and its biotechnological applications in metal recovery from ores and electronic waste using cyanide-producing bacteria. His lab employs techniques like heterologous gene expression, protein characterization, and 3D structure analysis in collaboration with institutions in Portugal and Germany.

• Sulfur biochemistry
• Microbial bioenergetics
• Sulfur metabolism
• +۷ مورد دیگر

Wei-Jun Qian is a distinguished Bioanalytical Chemist and Lab Fellow at Pacific Northwest National Laboratory (PNNL), where he has been conducting groundbreaking research in the Integrative Omics group within the Biological Sciences Division since 2002. His work focuses on developing advanced mass spectrometry-based approaches to quantify dynamic changes in protein abundances and post-translational modifications with applications in diabetes, oxidative stress, and other clinical areas. Education: PhD in Bioanalytical Chemistry, University of Florida BS in Chemistry, Nanjing University Dr. Qian's research centers on the development and applications of mass spectrometry-based proteomics approaches. He has pioneered chemical proteomic methods for site-specific quantification of cysteine-based redox modifications and sensitive selected reaction monitoring techniques. His work spans pancreatic islet biology, diabetes research, and oxidative stress-related disease mechanisms, contributing significantly to our understanding of protein dynamics in health and disease. His innovative approaches have enabled more precise quantification of protein modifications at stoichiometric levels. Analysis of Dr. Qian's recent publications reveals a strong focus on redox proteomics, particularly in quantifying protein thiol modifications in diabetes and oxidative stress contexts. His work increasingly incorporates nanoproteomics approaches for single-cell analysis and has expanded into clinical applications including cancer, neurodegenerative diseases, and environmental toxicology. The publications demonstrate his leadership in method development for quantitative proteomics, with emphasis on precision, sensitivity, and clinical translation. Scientific Awards: Presidential Early Career Award for Scientists and Engineers (2011) Director's New Innovator Award, National Institutes of Health (2009) Dr. Qian actively mentors postdoctoral researchers and intern students, fostering the next generation of proteomics scientists. His research has been supported by significant funding from NIH and other agencies, enabling cutting-edge instrumentation and collaborative projects. He maintains strong collaborations with clinical researchers to translate proteomic discoveries into potential diagnostic and therapeutic applications, particularly in diabetes and related metabolic disorders. As a Lab Fellow at PNNL, Dr. Qian leads a research team within the Integrative Omics group that specializes in developing and applying advanced mass spectrometry technologies. His laboratory is equipped with state-of-the-art proteomics instrumentation and has established protocols for redox proteomics, targeted quantification, and single-cell proteomics. The team collaborates extensively with researchers across PNNL and with external academic and clinical institutions.

• Mass Spectrometry
• Proteomics
• Protein Post-translational Modifications
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Ionela Florentina Negoita is a Researcher at the Center for Basic Metabolic Research (CBMR), Faculty of Health and Medical Sciences, University of Copenhagen, where she contributes to the Sakamoto Group's investigations into molecular mechanisms of metabolic disorders including diabetes and obesity. Her work focuses on experimental research in protein regulation and cellular signaling pathways. Her research spans metabolism, cell signaling, and molecular biology with specific expertise in protein modifications (persulfidation, phosphorylation), kinase regulation, and glucose uptake mechanisms in skeletal muscle and adipose tissue. This work addresses fundamental questions about how post-translational modifications regulate cellular processes in metabolic health and disease states. Analysis of her 2020-2024 publications reveals a cohesive research trajectory examining signaling pathways in metabolic tissues, including method development for protein modification quantification, transcription factor regulation, and tissue-specific metabolic responses. Her studies collectively advance understanding of molecular dysregulation in obesity-related disorders. As an active member of the Sakamoto Group at CBMR, Dr. Negoita collaborates with international researchers to investigate metabolic regulation through multidisciplinary approaches, contributing to the center's mission of developing therapeutic strategies for metabolic diseases.

• Metabolism
• Cell Signaling
• Molecular Biology
• +۳ مورد دیگر

Xuanmao Chen is an Associate Professor in the Department of Molecular, Cellular, and Biomedical Sciences at the University of New Hampshire (UNH), affiliated with the College of Life Sciences and Agriculture. His research focuses on hippocampal memory formation and primary cilia signaling, with a vision to bridge fundamental neuroscience with translational medicine. He teaches courses in pharmacology and molecular biology, and has trained students in techniques ranging from molecular biology to in vivo calcium imaging. Education: Ph.D. in Physiology from the University of Tübingen, Germany; M.S. in Genetics from Fudan University, China; B.S. in Biology from Nanchang University, China. Research Interests: Chen's lab investigates how hippocampal neurons encode associative memories and how ciliary signaling impacts neurodevelopment. Key discoveries include the role of burst synchronization in trace fear memory and the discovery of postnatal neuronal reverse movement guided by cilia directionality. Research methods include patch-clamp electrophysiology, in vivo imaging, and transgenic animal models. Funding: NIH grants (K01AG054729, P20GM113131, R15MH126317), COLE Research Awards, Hamel Center grants, and UNH fellowships. His lab collaborates widely, with publications in Molecular Neurobiology, Molecular Brain, and Current Biology. Labs/Teams: Directs a multidisciplinary team with expertise in molecular biology, electrophysiology, and behavioral analysis. Lab members include graduate and undergraduate students working on projects related to neural activity hierarchy and ciliary dysfunction in cognitive disorders.

• Hippocampal Memory Formation
• Primary Cilia Signaling
• Neuronal Activity Hierarchy
• +۶ مورد دیگر