معرفی
Tobias Dick serves as Professor and Head of the Division of Redox Regulation at the German Cancer Research Center (DKFZ) in Heidelberg, maintaining a primary affiliation with Heidelberg University's Faculty of Biosciences. His leadership spans molecular switch research within the SFB/TRR186 consortium focusing on spatio-temporal control of cellular signal transmission.
Academic Background:
- PhD in Biochemistry, Freie Universität Berlin (1997, summa cum laude)
- Habilitation in Biochemistry, Heidelberg University (2009)
- Diploma thesis at German Cancer Research Center (1994)
- Study program in Biochemistry, Freie Universität Berlin (1989-1994)
Research Focus: Dick pioneers investigations into thiol-based redox switches governing cellular signal transduction. His work establishes fundamental mechanisms of peroxiredoxin-mediated hydrogen peroxide signaling, protein persulfidation dynamics, and sulfur-based radical scavenging systems. Key contributions include developing real-time imaging probes for redox species and elucidating redox relays connecting peroxiredoxins to transcription factors like STAT3. Current research explores hydropersulfide protection against ferroptosis and metabolic adaptation through redox-sensitive enzymes.
Publication Trends: Over 15 years of high-impact publications reveal an evolutionary trajectory from foundational redox imaging techniques (2008-2011) to sophisticated molecular mechanism studies (2013-2020), culminating in recent breakthroughs on sulfur signaling in cell death pathways (2023). His work consistently appears in premier journals like Nature Chemical Biology, demonstrating sustained innovation in redox biology methodology and conceptual frameworks.
Scientific Recognition:
- ERC Advanced Grant (2017)
- Society for Free Radical Research Europe Basic Science Award (2017)
- Chica- and Heinz-Schaller-Award for young scientists (2009)
- Marie Curie Excellence Grant (2004)
- DFG Postdoctoral Fellowship (1998-2000)
- Studienstiftung des Deutschen Volkes Scholarship (1989-1994)
Leadership & Mentorship: As founding vice-coordinator of DFG priority program SPP1710 (2014-present) and GBM Redox Biology Study Group (2011-2017), Dick shapes national research agendas. His division at DKFZ mentors next-generation scientists through ERC and DFG-funded projects, with trainees contributing to landmark publications on redox switches and cellular physiology.
Research Infrastructure: The Division of Redox Regulation operates within DKFZ's state-of-the-art facilities, collaborating extensively through the SFB/TRR186 consortium. This environment enables cutting-edge investigations into redox-controlled cellular processes using advanced biochemical, imaging, and computational approaches.
