جستجوی استاد راهنمای دانشگاهی

Vincent Crynsمشاهده پروفایل

استاد

• Cancer Biology
• Oncology
• Endocrinology
• +۴ مورد دیگر

Dr. Vincent Cryns is a Professor in the Department of Medicine at the University of Wisconsin-Madison School of Medicine and Public Health. He serves as Chief of the Division of Endocrinology, Diabetes and Metabolism and holds the Marian A. and Rodney P. Burgenske Chair in Diabetes Research. His research focuses on cancer metabolism, particularly the connections between metabolic stress and breast cancer progression. He co-leads the Physician-Scientist Training Program (PSTP) and is a member of prestigious organizations like the American Society for Clinical Investigation. Education : MD from Harvard Medical School Internship in Internal Medicine at Massachusetts General Hospital Residency in Internal Medicine at Dartmouth-Hitchcock Medical Center Clinical Fellowship and Research Fellowship in Medicine at Harvard Medical School Research Interests : Dr. Cryns investigates 'third messenger' pathways involving lipid second messengers in the nucleus, particularly how these pathways protect cancer cells from metabolic stress. His lab, the Third Messenger Lab (collaborating with Dr. Richard Anderson), has identified novel drug targets and signaling mechanisms linked to p53 and Akt activation. His work is funded by the NIH, Department of Defense, and the Breast Cancer Research Foundation. Key Contributions : His team discovered that nuclear phosphoinositide kinases and p53 form a signalosome regulating AKT activation, and that alphaB-crystallin promotes cancer metastasis. Recent studies explore metabolic vulnerabilities in triple-negative breast cancer and the role of methionine restriction. Grants & Awards : NIH grants (NCI, NIA) Department of Defense Breast Cancer Research Program National recognition (Best Doctors in America) Media features in Nature, NPR, and Oprah Magazine Labs & Teams : The Cryns Lab actively recruits scientists and focuses on cancer metabolism and third messenger pathways. Collaborations include developing nanoparticulate drug formulations and investigating nuclear phosphoinositide signaling in metastasis.

Jean Publicoverمشاهده پروفایل

پژوهشگر

• Viral Immunology
• Hepatology
• Vaccine Development
• +۴ مورد دیگر

Dr. Jean Publicover is a researcher at the University of California, San Francisco (UCSF), with expertise in viral immunology, hepatology, and vaccine development. She holds a PhD in Viral Pathogenesis and Vaccine Development from Yale University (2006) and a B.S. in Microbiology from the University of Rochester (2001). Her research focuses on understanding immune mechanisms against hepatitis B virus (HBV), T-cell biology, and cytokine signaling in liver diseases. Dr. Publicover has been recognized with grants and fellowships, including the NIDDK K01 Award (2013-2018) and the UCSF Liver Center Pilot Grant (2015-2016). Education: PhD in Viral Pathogenesis (Yale, 2006), B.S. Microbiology (Rochester, 2001) Her research interests include age-dependent immune responses to HBV, Treg cell enrichment in tumors, and integrin-mediated immune regulation. She has contributed to the development of novel vaccine vectors and bioinformatics tools for immunological data analysis (e.g., Cyclone pipeline). Her work bridges basic science and clinical translation, addressing challenges in viral immunity and cancer immunotherapy. Scientific Awards: UCSF Liver Center Pilot Feasibility Grant (2015-2016) NIDDK K01 Award (2013-2018) Giannini Foundation Fellowship (2008-2011) Her publications span immunology, hepatology, and virology, with a focus on HBV pathogenesis, T-cell interactions, and cytokine signaling. She has collaborated on projects involving TGF-β activation, OX40/OX40L signaling, and integrin biology in tumor microenvironments.

Richard N Sifersمشاهده پروفایل

استاد

• Glycobiology
• Secretory Pathway
• Protein Biosynthetic Quality Control
• +۵ مورد دیگر

Richard N Sifers, Ph.D. , is a Professor in the Department of Pathology & Immunology at Baylor College of Medicine . He serves as Director of Operations & Membership for the Center for Drug Discovery and is a member of the Dan L Duncan Comprehensive Cancer Center . Ph.D. (1984) - University of Oklahoma College of Medicine B.S. (1978) - Missouri Western State University His research focuses on protein biosynthetic quality control in the secretory pathway, particularly the role of ERManI in degradation of misfolded glycoproteins and its implications in alpha1-antitrypsin deficiency-related liver disease . His work explores how ER stress responses and conformational diseases intersect in cancer cell pro-survival mechanisms. Key publication trends include studies on glycoprotein degradation signals , ER-Golgi mannosidase dynamics , and disease modifier mechanisms in protein folding disorders. His recent articles emphasize translational regulation of ERManI and its therapeutic potential in hepatocellular carcinoma . He is affiliated with multiple centers including the Huffington Center on Aging , Human Genome Sequencing Center , and Digestive Disease Center . Current projects involve dissecting ERManI regulatory pathways and exploring its role as a diagnostic marker for liver diseases.

Dennis W. McGeeمشاهده پروفایل

استاد

• Immunology
• Cell Biology
• Molecular Biology
• +۴ مورد دیگر

Dennis W. McGee is a Professor in the Department of Biological Sciences at Binghamton University. His research focuses on mucosal immunology, specifically the role of intestinal epithelial cells (IEC) in immune and inflammatory responses. He investigates cytokine regulation via integrin-extracellular matrix interactions and signaling pathways like NF-kB and AP-1. Education: PhD, Texas A&M University MS and BA, University of New Orleans Research emphasizes mechanisms governing IEC cytokine production (IL-6, IL-8, MCP-1) and potential applications in disease treatment and vaccine development. No awards or publications are listed here, though his work contributes to understanding intestinal mucosal defense.

Jason T. Yusteinمشاهده پروفایل

دانشیار

• Pediatric Sarcomas
• Sarcoma Metastasis
• Cancer Therapeutics
• +۵ مورد دیگر

Jason T. Yustein, M.D., Ph.D., is an Associate Professor in the Department of Pediatrics, Hematology-Oncology at Baylor College of Medicine. He also serves as Co-Associate Director of Education at the Dan L Duncan Comprehensive Cancer Center and Director of the Faris D. Virani Ewing Sarcoma Center at Texas Children's Cancer Center. His research focuses on the molecular mechanisms underlying pediatric sarcomas, particularly Ewing sarcoma and osteosarcoma, emphasizing metastasis, therapeutic resistance, and novel treatment strategies. Dr. Yustein obtained a BA from the University of Virginia (1994), followed by an MD-PhD from Case Western Reserve University School of Medicine (2002). He completed fellowships and residencies in Pediatrics, Hematology-Oncology at Johns Hopkins University Hospital (2003–2008). His research interests include investigating the molecular pathogenesis of pediatric sarcomas, targeting signaling pathways (e.g., Wnt/β-catenin, integrin-mediated signaling), and developing therapies such as CAR T-cell therapies and nanoparticle-based drug delivery systems. Recent work explores biomarkers for prognosis and therapeutic efficacy, including miRNA signatures and epigenetic regulators. Key contributions include studies on tumor metastasis, CAR T-cell activity modulation, and preclinical models for sarcomas. His team collaborates on translational research to bridge laboratory findings to clinical applications in pediatric oncology.

Andrew Capelمشاهده پروفایل

مدرس ارشد

• Bioengineering
• Regenerative Medicine
• Tissue Engineering
• +۶ مورد دیگر

Dr. Andrew Capel is a Senior Lecturer in Bioengineering and Regenerative Sciences at Loughborough University's School of Sport, Exercise and Health Sciences. He holds a PhD from the same institution and has expertise in bioengineered tissue models, 3D printing applications in biomedicine, and musculoskeletal systems. His career includes roles as a research associate and senior research associate, working with Prof. Mark Lewis on musculoskeletal bioengineering. He leads research in areas like bio-hybrid prosthetics, neuronal guidance systems, and vascularized tissue constructs. Education: BSc in Chemistry and Sports Science (2010) MSc in Pharmaceutical Science and Medicinal Chemistry (2011) PhD in 3D Printing for Fluidic Devices (2014) Research Interests: Focuses on bioengineered models of muscle and nervous systems, 3D-printed biomedical tools, and regenerative therapies. His work spans tissue engineering, neuro-regeneration, and biomedical material development. He collaborates with networks like the Rehabilitation Technologies Network and explores applications in drug testing and prosthetic design. Labs & Collaborations: Engaged with Myomaker Bio, a contract research organization specializing in muscle biology testing. Active in the Lifestyle for Health and Wellbeing research group. Previously developed open-source 3D-printed fluidic systems and advanced bioengineered muscle constructs capable of functional regeneration.

Scott Woodمشاهده پروفایل

دانشیار

• Biomedical Engineering
• Tissue Engineering
• Cell Biology
• +۳ مورد دیگر

Scott Wood is an Associate Professor of Biomedical Sciences at the University of Maine and Director of the Portland Laboratory for Biotechnology and Health Sciences. His research focuses on tissue engineering strategies to study cellular responses to physical stimuli, including chondrocyte cytoskeleton homeostasis and integrin signaling pathways. He leads the development of the Microphysiological Articular Joint In a Chip (MAJIC) system for drug screening in articular joints. Education: Ph.D. in Bioengineering, Clemson University, 2011 M.S. in Bioengineering, Clemson University, 2010 B.S. in Mechanical Engineering, Texas Tech University, 2005 Certificate in Technology Entrepreneurship, Clemson University, 2011 Research Highlights: Combines 3D printing, biomaterials, and biomechanical analysis to address knee osteoarthritis. Utilizes atomic force microscopy, fluorescence microscopy, and immunocytochemistry for cellular studies. Expertise spans applied mathematical modeling, microfluidics, and drug screening platforms. Lab & Affiliations: Portland Laboratory for Biotechnology and Health Sciences (Portland, ME) and the Graduate School of Biomedical Science and Engineering (Orono, ME). Coordinates multi-tissue joint modeling initiatives with clinical and engineering collaborators.

• Mechano-Redox Biology
• Thrombosis Research
• Protein Disulfide Isomerase
• +۳ مورد دیگر

Dr. Joyce Chiu is a Research Fellow at the School of Medical Sciences, University of Sydney's Faculty of Medicine and Health. She pioneers research in mechano-redox biology, focusing on disulfide bond dynamics in vascular processes. Her investigations span thrombosis regulation, angiogenesis, inflammation, and metabolic pathways, employing proteomic methods to quantify redox changes at atomic resolution. She discovered novel regulatory mechanisms for secreted protein disulfide isomerase (PDI) in thrombosis and neutrophil migration. Dr. Chiu's recent publications demonstrate how mechanical forces and redox reactions cooperatively regulate integrin-mediated cell adhesion and directional movement under flow conditions, with implications for cardiovascular therapeutics. Helen and Robert Ellis Fellowship (2017-2019) Professor Tony Basten Fellowship (2018) Outstanding Young Scientist Award (2021) Oral Communication Award (2022)

Tassos Perrakisمشاهده پروفایل

استاد

• Structural Biology
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Prof. Tassos Perrakis is a Professor in the Department of Structural Biochemistry at Utrecht University's Faculty of Science. His research focuses on structural biology, biochemistry, and molecular mechanisms of proteins, particularly enzyme structures and their roles in cellular processes. He leads the 'Macromolecular Structures' research group and teaches 'Advanced Structural Biology.' Key research areas include structural elucidation of protein complexes (e.g., tubulin tyrosine carboxypeptidase), enzymology, and development of structural biology tools. His work has been published in high-impact journals like Nature and Nature Structural and Molecular Biology . Prof. Perrakis collaborates on projects involving protein crystallization, metabolic pathway analysis, and zebrafish models for developmental biology. He is affiliated with the Biomolecular Sciences program and contributes to the West-Life Virtual Research Environment initiative. No scientific awards are explicitly listed, though his impactful publications suggest recognition in the field. Teaching and supervision activities are tied to structural biology coursework and graduate training in the department.

Linda Bojmarمشاهده پروفایل

استادیار

• Cancer Biology
• Metastasis Research
• Extracellular Vesicles (EVPs)
• +۳ مورد دیگر

Linda Bojmar is an Assistant Professor and Docent at Linköping University, affiliated with the Department of Biomedical and Clinical Sciences and the Division of Surgery, Orthopedics and Oncology. Her research focuses on understanding crosstalk between organs in cancer progression, particularly pancreatic cancer and hepatic metastasis. She leads the Bojmar Lab, which investigates the pre-metastatic niche and the role of extracellular vesicles (EVPs) in cancer spread. Key projects include developing protocols for EVP characterization and using liver biopsies to predict metastasis outcomes. She has secured grants totaling over 6.8 million SEK from the Swedish Society for Medical Research and other agencies. Her work bridges clinical and preclinical research, involving collaborations across institutions in Sweden and the U.S. Research interests span pancreatic cancer biology, liver metastasis mechanisms, and translational oncology. She emphasizes interdisciplinary teamwork and aims to translate findings into clinical applications, such as biomarker development and targeted therapies. Linda’s lab collaborates with clinicians and researchers globally, including work at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center. Future goals include expanding studies on gastrointestinal cancers and exploring EVP-based therapies.

Paul Markus Müllerمشاهده پروفایل

پژوهشگر

• Membrane Biochemistry
• Cell Biology
• Molecular Biology
• +۳ مورد دیگر

Dr. Paul Markus Müller is a Biochemistry Researcher at the Department of Biochemistry, part of the Freie Universität Berlin. His research focuses on membrane biochemistry, particularly the study of cellular membrane dynamics, Rho GTPase signaling, and advanced microscopy techniques. He is affiliated with the Ewers Group - Membrane Biochemistry, where his work explores mechanisms of endocytosis, protein-lipid interactions, and nanoscopic structures using cutting-edge methods like superresolution microscopy and correlative imaging. His research interests include understanding how adhesion energy influences lipid binding during endocytosis, developing screening-compatible assays for Rho GTPase activity, and analyzing spatial organization of signaling pathways. Müller has contributed to studies on the anticancer effects of phytochemicals and the role of oxidative stress in cellular processes. Publications highlight trends in combining biochemistry with advanced imaging, particularly in resolving membrane structures and signaling events at the nanoscale. His work bridges molecular mechanisms with physiological outcomes, such as aquaporin translocation in renal cells and cancer cell migration inhibition. Müller is based at Thielallee 63, Room 108b, Berlin, and can be reached via email at paulmarkus.mueller@fu-berlin.de .

Eva Antonمشاهده پروفایل

استاد

• Neurodevelopment
• Neuronal Migration
• Cerebral Cortex Development
• +۳ مورد دیگر

Eva Anton, PhD is a Professor in the Department of Cell Biology and Physiology at the University of North Carolina School of Medicine. Her research focuses on mechanisms governing cerebral cortex development, including radial glial progenitor function, neuronal migration, and neurogenesis. Key areas include how disruptions in these processes contribute to disorders like autism, schizophrenia, and cortical malformations. Her work integrates molecular, cellular, and systems approaches to study neuronal placement, connectivity formation, and the roles of primary cilia in brain development. She leads the Anton Lab, with funding supporting studies on neurodevelopmental disorder mechanisms. Recent publications emphasize primary cilia's role in cortical architecture and microglial development regulated by radial glial signaling. Her research bridges basic science and clinical insights into neurological conditions.

• Dermatology
• Dermatologic Oncology
• Cutaneous Infections
• +۳ مورد دیگر

David Eric Sawcer, MD, PhD, is a Clinical Associate Professor of Dermatology at the University of Southern California (USC), specializing in clinician-educator roles. His research focuses on dermatologic oncology, viral skin infections, and innovative therapies such as nanosecond pulsed electric fields (nsPEF) for skin cancers. He has contributed to understanding SARS-CoV-2 treatment timing and HIV-associated dermatologic conditions. His work spans clinical trials, laser therapies, and cellular mechanisms of skin diseases. Research interests include cutaneous manifestations of systemic diseases, targeted cancer therapies, and laser applications in cosmetic and medical dermatology. Recent studies emphasize optimizing treatments for viral infections and cancer while minimizing normal tissue damage. His publications reflect a multidisciplinary approach, combining clinical practice with biophysical and genetic research. Publications highlight advancements in nsPEF for squamous cell carcinoma, collagen-driven fibroblast migration mechanisms, and snake venom-derived anticancer agents. His work on multiple sclerosis genetics and laser treatments for pigmented lesions underscores long-term contributions to dermatology and related fields.

Sandra Loerakkerمشاهده پروفایل

دانشیار

• Mechanobiology
• Tissue Engineering
• Cardiovascular Biomechanics
• +۲ مورد دیگر

Dr. Sandra Loerakker is Associate Professor in Biomedical Engineering at Eindhoven University of Technology, specializing in soft tissue biomechanics and mechanobiology. She leads research on computational modeling of cardiovascular tissue growth and remodeling for regenerative medicine applications. Her research integrates: Computational modeling of soft tissue mechanobiology Heart valve and cardiovascular tissue engineering Multiscale analysis of growth and remodeling processes Experimental validation of computational predictions Research outputs focus on tissue-engineered heart valve optimization, vascular smooth muscle responses to mechanical stimuli, and renal epithelial polarization mechanics. Recent publications demonstrate innovations in in silico modeling of cardiovascular implants and experimental techniques for tissue characterization. Significant recognitions: ERC Starting Grant (2018) NWO Vidi Grant (2022) Best Doctoral Thesis in Biomechanics Award (2012) Best Master Teacher (2021-2022) Dr. Loerakker directs the Modeling in Mechanobiology group and serves on the Council of the European Society of Biomechanics. Her work contributes to UN Sustainable Development Goals for health and well-being.

• Structural Biology
• Membrane Proteins
• Transmembrane Signaling
• +۳ مورد دیگر

Tobias S Ulmer is an Associate Professor of Physiology and Neuroscience at the University of Southern California (USC), specializing in structural biology of membrane proteins and transmembrane signaling. His research uses high-resolution solution-state NMR spectroscopy to study molecular mechanisms underlying physiological and pathological processes. Undergraduate: University of Zurich PhD: University of Oxford Postdoctoral Work: National Institutes of Health (NIH) Affiliation: USC His research focuses on three-dimensional protein structures, dynamics, and interactions (protein-protein, protein-lipid) at atomic resolution. Key projects include analyzing transmembrane signaling in cell surface receptors and regulatory mechanisms of carnitine palmitoyltransferase 1. He investigates how membrane proteins adapt to force-modulated lipid bilayers and their role in mechanosensing. Publications highlight his work on integrin aIIbß3 transmembrane interactions, EZH2 phosphorylation in cancer, huntingtin exon 1 folding, and histone modifications in osteoclastogenesis. His expertise spans NMR spectroscopy, isothermal titration calorimetry, and membrane protein biophysics. Dr. Ulmer's lab has contributed to understanding integrin activation mechanisms, membrane protein assembly principles, and cancer-related gene silencing pathways. His work bridges structural biology, neuroscience, and oncology, with implications for neurodegenerative and malignant diseases.