جست‌وجوی استاد و پژوهشگر

• Tumor Microenvironment
• Tumor Immune Heterogeneity
• B Cell Malignancies
• +۳ مورد دیگر

Chuan Liu is a Research Fellow in Genetics at Yale School of Medicine and a PhD candidate in Medical Oncology at Zhejiang University. His research focuses on tumor microenvironment dynamics and tumor immune heterogeneity, with a current project investigating Wnt/beta-catenin signaling in B cell malignancies under the mentorship of Kadriye Nehir Cosgun in the Müschen Lab. He holds dual affiliations between Yale and Zhejiang University, combining clinical insights with molecular oncology. Education: Pursuing PhD in Medical Oncology at Zhejiang University. Research interests span immunotherapy strategies, cancer heterogeneity, and signaling pathways in hematologic malignancies. His work bridges basic science with translational medicine, particularly in understanding how microenvironmental interactions influence cancer progression. Research highlights include studies on TNFR signaling in intervertebral disc repair, progranulin's role in bone metabolism, and the therapeutic potential of sodium channel modulation in non-neuronal tissues. His recent publications explore novel peptide inhibitors for inflammatory arthritis and molecular mechanisms underlying glucocorticoid-induced bone loss. Lab affiliations include the Müschen Lab at Yale, where he collaborates on B-cell malignancy projects. While no awards are listed, his work reflects contributions to multiple disease areas including osteoarthritis, Gaucher disease, and systemic lupus erythematosus through innovative molecular approaches.

Michael O. Hottigerمشاهده پروفایل

استاد

• Molecular Biology
• Inflammation
• ADP-Ribosylation
• +۳ مورد دیگر

Prof. Michael O. Hottiger is a full professor of Molecular Biology and the acting director of the Department of Molecular Mechanisms of Disease at the University of Zurich. He holds a dual degree in Veterinary Medicine and Molecular Biology from the University of Zurich and has held positions at the Howard Hughes Medical Institute (USA) before joining the University of Zurich in 1998. His research focuses on the molecular mechanisms of inflammation, particularly the role of ADP-ribosylation in regulating immune responses and cellular stress. He co-founded DUALSYSTEMS Biotech AG and has received notable awards, including the Dr. Ernst Th. Jucker Award (2001) and the PHOENIX Pharmazie-Wissenschaftspreis (2004). Education: University of Zurich: Veterinary Medicine and Molecular Biology Howard Hughes Medical Institute, University of Michigan (Postdoctoral Training) Research Interests: ADP-ribosylation in inflammation and disease Post-translational modifications (PTMs) in cellular signaling Proteomics-based approaches for ADP-ribosylation analysis Awards: Dr. Ernst Th. Jucker Award (2001) PHOENIX Pharmazie-Wissenschaftspreis (2004) His lab employs cutting-edge techniques like mass spectrometry to study ADP-ribosylation patterns and their role in diseases such as cancer and inflammatory disorders. Recent work highlights the prognostic value of ADP-ribosylation levels in renal cell carcinoma and the regulatory interplay between ADP-ribosyltransferases and key signaling pathways.

Paige Erpfمشاهده پروفایل

پژوهشگر ارشد

• Synthetic Biology
• Genetic Engineering
• Yeast Biology
• +۴ مورد دیگر

Paige Erpf is a Postdoctoral Fellow and Synthetic Biologist at Macquarie University's School of Natural Sciences and the ARC Centre of Excellence in Synthetic Biology. She specializes in genetic engineering of both industrial and pathogenic yeast, with a focus on developing the first synthetic yeast strain and engineering microbes to address climate change challenges. Paige graduated from The University of Queensland with an undergraduate degree in Zoology and Biochemistry and Molecular Biology, followed by a PhD in Biochemistry and Molecular Biology. Her academic journey has positioned her at the forefront of synthetic biology research. Paige's research focuses on transforming ordinary yeast into miniature cell factories that produce biofuels, plastics, and medicines. She specializes in genetic engineering of industrial and pathogenic yeast, with significant work on Cryptococcus neoformans. Her research explores how engineered microbes can work together to tackle problems arising from climate change, representing an innovative approach to environmental challenges through synthetic biology. Her publication record shows a strong trajectory in synthetic biology and fungal pathogenesis, with recent high-impact work on synthetic chromosome design and construction. Her research spans fundamental yeast biology to applied antifungal drug discovery, demonstrating both theoretical depth and practical applications in microbial engineering. Notable recognition: Superstar of STEM (2023) Paige has mentored and supervised several master's and PhD students, undergraduates, and high school students on placement. She actively contributes to education through guest lectures in courses covering synthetic biology, microbiology, and ribosome translation. Her outreach extends beyond academia, as she ventured into science comedy in 2023, performing at the Enmore Theatre Wildflower Bar and Sydney Fringe Festival, and appearing on the National Science Quiz. As a member of the ARC Centre of Excellence in Synthetic Biology, Paige collaborates with researchers across institutions on cutting-edge synthetic genome projects. She has participated in a global consortium working on building the first synthetic genome, demonstrating her integration into international research networks focused on advancing synthetic biology capabilities.

Nukhet Aykin-Burnsمشاهده پروفایل

دانشیار

• Reactive Oxygen Species (ROS)
• Mitochondrial Function
• Radiation-Induced Normal Tissue Damage
• +۴ مورد دیگر

Nukhet Aykin-Burns is an Associate Professor of Pharmaceutical Sciences at the University of Arkansas for Medical Sciences (UAMS) College of Pharmacy, with a secondary appointment in the Human Toxicology Program at The University of Iowa. Her research focuses on reactive oxygen species (ROS), mitochondrial function, and mechanisms of radiation-induced (IR/UV) normal tissue damage, wound healing, and polychlorinated biphenyl (PCB)-induced oxidative stress. She also leads efforts to develop radioprotectors and radiomitigators for Acute Radiation Syndromes (ARS). Recent publications highlight her work in radiation biology, oxidative stress, mitochondrial dysfunction, and toxicant-induced metabolic alterations. Themes include epigenetic regulation of immune cells, antioxidant therapies in radiation injury, and the interplay between environmental toxicants and cellular metabolism. Her laboratory investigates the molecular underpinnings of radiation and toxicant exposure, with a particular emphasis on mitochondrial-targeted interventions and translational applications for human health.

• Epigenetics
• Hematology
• Cell Biology
• +۳ مورد دیگر

Andreas Lennartsson is a Principal Researcher and Docent at Karolinska Institutet's Department of Medicine, Huddinge. His research group focuses on epigenetic regulation in acute myeloid leukemia (AML) and normal blood development. He leads a multidisciplinary team investigating metabolic-epigenetic interactions, drug responses, and novel therapies for AML. Previously, he completed postdoctoral training at RIKEN (Japan) and Karolinska Institutet, and holds a PhD in Experimental Hematology from Lund University. His work integrates genomic technologies, molecular biology, and clinical collaborations to advance AML treatment. Education: Master's Degree in Biotechnology (Lund University), PhD in Experimental Hematology (Lund University), Postdoctoral Training at RIKEN (Japan) and Karolinska Institutet. Research Interests: Epigenetic dysregulation in AML, metabolic-epigenetic networks, leukemia stem cells, drug development, and hematopoietic differentiation. His lab uses iPS cells, patient-derived models, and advanced transcriptomic/epigenomic tools to identify therapeutic targets. Funding: Supported by grants from Barncancerfonden, Cancerfonden, Radiumhemmets forskningsfonder, Vetenskapsrådet, and others. Collaborations include FANTOM consortia and international research networks. Labs/Teams: Epigenetic regulation of leukemia research group at Huddinge, affiliated with the Center for Hematology and Regenerative Medicine (HERM). Current PhD student: Aonghus Naughton.

• Epigenetics
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Alberto Zullo is an Associate Professor at the Department of Science and Technology (DST) , University of Sannio , with a focus on BIO/10 - Biochemistry . He has published extensively on epigenetics, cardiovascular diseases, diabetes, and genetic disorders. Research Interests : Epigenetic mechanisms in chronic diseases, sirtuin gene regulation, cardiac fibrosis, and muscle repair. Key Publications : Explore transgenerational epigenetics (2014), type 2 diabetes epigenetics (2017), cardiac fibrosis (2017), and RYR1 mutation analysis (2006-2020). Contact : albzullo@unisannio.it

• Metabolism
• Immunology
• Biochemistry
• +۳ مورد دیگر

Vincent de Boer is an Assistant Professor at Wageningen University in the Department of Human and Animal Physiology and holds a WIAS Assistant Professor appointment. His research focuses on metabolism and immunology with expertise in extracellular flux analysis, oxygen consumption, and metabolic pathways using models ranging from cell lines to mice and zebrafish. His research spans metabolic regulation in health and disease, investigating SIRT5 function, mitochondrial fitness, and immune-metabolic crosstalk. Key methodologies include flux analysis of peripheral blood mononuclear cells, protein degradation studies under hypoxia, and development of bioinformatics tools for cellular imaging. Work has implications for understanding intestinal diseases, muscle atrophy, and metabolic disorders. Recent publications (2024-2025) demonstrate strong continuity in metabolic research, featuring SIRT5 neuropathology studies, hypoxia-induced protein catabolism mechanisms, and innovative data analysis tools. The work bridges fundamental biochemistry with physiological applications in aging, immunity, and tissue-specific metabolism. He has co-supervised five PhD students on critical projects: Interleukin-22 in zebrafish intestinal health and disease Protein fermentation impacts on pig intestinal barrier function Dietary approaches to improve innate immune health White adipose tissue adaptive capacity mechanisms Pseudo-hypoxia targeting for muscle mitochondrial fitness in aging Research is supported through multiple active and completed projects investigating metabolic health optimization through diet, mitochondrial function, and tissue-specific adaptations, with strong institutional backing from Wageningen University & Research.

• Neurobiology
• Neurodegenerative Diseases
• Molecular Neuroscience
• +۳ مورد دیگر

María del Carmen Díaz Ruiz is a Professor in the Department of Morphological Sciences at the University of Santiago de Compostela (USC), affiliated with the Faculty of Medicine and Dentistry. She leads research within the Parkinson neurobiol Group of Molecular and Cellular Neurobiology of Parkinson's Disease at the Center for Research in Molecular Medicine and Chronic Diseases (CIMUS) . Her work focuses on neurodegenerative mechanisms, particularly the role of the renin-angiotensin system (RAS) in neuroinflammation and aging-related neurodegeneration in the substantia nigra. She holds a PhD from the University of Barcelona (1995), where her thesis explored immunochemical studies of TGF-alpha, TGF-beta, and EGF receptors in avian and rodent kidneys. Her research integrates molecular biology, cellular neurobiology, and translational approaches to understand Parkinson's disease pathophysiology. Key research interests include: Molecular mechanisms of neuroinflammation Angiotensin II signaling in glial cells Role of Sirtuins and IGF-1 in neuroprotection Aging-related neurodegenerative pathways Therapeutic targets for dopaminergic neuron preservation Her publications (2001–2023) highlight advancements in understanding RAS modulation, NLRP3 inflammasome activity, and microglial responses in neurodegeneration. Active collaborations involve exploring exercise-induced neuroprotective effects and polyphenol-based interventions for tauopathies. Currently affiliated with multiple neurobiological research initiatives, her work bridges basic science and clinical applications in neurodegenerative diseases.

• Metabolic Disorders
• Hepatology
• Molecular Biology
• +۳ مورد دیگر

Dr. MARIA JESUS GONZALEZ RELLAN is a Marie Curie Contract Researcher at the University of Santiago de Compostela's Department of Physiology, affiliated with the Center for Research in Molecular Medicine and Chronic Diseases (CIMUS). She specializes in molecular metabolism, focusing on mechanisms regulating glucose and lipid homeostasis in liver pathologies. Her work bridges basic research and translational medicine, particularly in NAFLD/NASH, fibrosis progression, and metabolic signaling pathways. Education: PhD in Physiology (2021) from the University of Santiago de Compostela, with a thesis titled 'Role of p53 in hepatic gluconeogenesis,' supervised by Dr. Rubén Nogueiras Pozo and Dr. Carlos Dieguez Gonzalez. Research interests include the molecular regulation of metabolic diseases, hepatic fibrosis pathways, and the role of post-translational modifications (e.g., O-GlcNAcylation, neddylation) in metabolic adaptation. Her recent studies highlight the therapeutic potential of targeting p63, HER2-ACC1 pathways, and mitochondrial dysfunction in liver diseases. Her publications (2021–2025) consistently investigate metabolic regulators in NAFLD, SARS-CoV-2 liver tropism in comorbidities, and pharmacological tools for fibrosis inhibition. She holds a Marie Curie grant supporting her research on molecular metabolism and translational therapeutics. Labs/Teams: MetaMol Molecular Metabolism Group (CIMUS), collaborating on multi-omics approaches to metabolic disease pathogenesis.

• Molecular Medicine
• Pharmacology
• Oncology
• +۳ مورد دیگر

Roman Perez Fernandez is a Professor at the Department of Physiology, University of Santiago de Compostela. He is affiliated with the Faculty of Medicine and Dentistry, and leads research at the Center for Research in Molecular Medicine and Chronic Diseases (CIMUS) and the Strategic Grouping in Materials (AEMAT). His work focuses on designing bioactive compounds and materials , particularly vitamin D analogues and stem cell therapies. He holds a PhD from the University of Santiago de Compostela (1987) with a thesis on adrenal androgen physiology. Research interests include molecular mechanisms of cancer progression, anti-fibrotic therapies, and stem cell secretome applications. Notable areas include breast cancer metastasis regulation via POU1F1 transcription factor, and development of novel vitamin D-based drugs targeting oncologic and metabolic conditions. His studies also explore the therapeutic potential of human uterine cervical stem cells in regenerative medicine and anti-inflammatory treatments. Publications highlight advancements in: 1) Design of anti-cancer vitamin D analogs with reduced calcemic side effects; 2) Role of p63 in hepatic glucose metabolism and fibrosis; 3) Mechanisms of cancer stem cell reprogramming; 4) Anti-inflammatory effects of conditioned stem cell media in ocular and gastrointestinal disorders. His work bridges organic chemistry, molecular biology, and clinical applications. Awards and grants are not explicitly listed, but his extensive publication record (over 70 papers from 1987–2025) reflects sustained research excellence. He collaborates across disciplines including material science (AEMAT) and molecular medicine (CIMUS). Current projects involve optimizing drug delivery systems using hydrogels and cyclodextrin complexes for targeted therapies.

• Redox Biology
• Neurodegeneration
• Iron Homeostasis
• +۳ مورد دیگر

PD Dr. rer. nat. Carsten Berndt leads research at the Department of Neurology, Heinrich Heine University Düsseldorf, focusing on thioredoxin-family oxidoreductases. His work bridges redox biology, iron homeostasis, and neuroinflammatory disease mechanisms. Medical Faculty affiliation Director of Thiology research group Research explores: Redox-controlled post-translational modifications FeS cluster biosynthesis in neurodevelopment Neuroinflammation and regeneration processes Ferroptosis sensitivity in brain cells Tumor cell invasion mechanisms Recent publications highlight thioredoxin family enzymes' roles in: Iron homeostasis (2020, 2011) Neuroglia migration (2022) GPX4-mediated ferroptosis prevention (2018) 2024 work on PRDX6 and selenium utilization

• Reproductive Physiology
• Endocrinology
• Animal Reproduction
• +۴ مورد دیگر

Luis Schütz is an Assistant Professor in the Department of Agriculture, Veterinary and Rangeland Sciences at the University of Nevada, Reno. His research focuses on reproductive physiology and endocrinology in cattle, aiming to enhance reproductive efficiency in beef and dairy production systems through a deep understanding of ovarian function and hormonal regulation. Research Interests: Reproductive physiology of cattle Endocrine regulation of ovarian follicular development Steroidogenesis in granulosa and theca cells Impact of environmental toxins on reproductive health Application of molecular techniques to improve livestock fertility His work integrates cellular and molecular biology approaches to study gene expression, hormonal signaling, and epigenetic regulation in bovine ovarian tissues. A recurring theme in his research is the role of growth factors and hormones such as FSH, IGF-1, BMPs, and asprosin in modulating reproductive outcomes. Publication Trends: Schütz’s research spans from 2015 to 2023, with a strong emphasis on understanding the molecular mechanisms underlying ovarian function in cattle. His studies often involve in vitro cell culture systems and transcriptomic profiling to uncover regulatory pathways. Recent work has explored the roles of novel peptides like asprosin and epigenetic modifications in reproductive performance. Scientific Awards: No specific awards or honors are listed in the provided text. Advising and Grants: While no specific students or grants are mentioned in the provided content, his collaborative publication record suggests active involvement in mentoring and research partnerships. Labs and Teams: Schütz is affiliated with the Department of Agriculture, Veterinary and Rangeland Sciences at the University of Nevada, Reno. His research likely involves collaboration with other faculty, graduate students, and external partners in veterinary and animal science disciplines.

Tihomir Balogمشاهده پروفایل

پژوهشگر

• Oxidative stress
• Antioxidant mechanisms
• Metabolism
• +۷ مورد دیگر

Dr. Tihomir Balog serves as Head of the Laboratory for Metabolism and Aging within the Division of Molecular Medicine at the Ruđer Bošković Institute in Zagreb, Croatia. His research focuses on understanding the molecular mechanisms underlying aging processes, with particular emphasis on oxidative stress, antioxidant defense systems, and metabolic regulation. With over two decades of research experience, he has established himself as a leading expert in studying sex-specific differences in stress response and mitochondrial function. Dr. Balog's primary research interests center around oxidative stress mechanisms and their relationship to aging processes. His laboratory investigates how sirtuins, particularly SIRT3, regulate redox homeostasis and metabolic pathways in a sex-dependent manner. His work has demonstrated significant gender differences in antioxidant enzyme activities and lipid peroxidation during aging. Current research focuses on how SIRT3 modulates mitochondrial function in response to hyperoxia and high-fat diets, with implications for understanding age-related diseases and developing targeted interventions. Analysis of Dr. Balog's recent publications reveals a strong focus on sex-specific differences in SIRT3-mediated regulation of redox and metabolic signaling. His work consistently demonstrates how males and females respond differently to oxidative stress, hyperoxia, and metabolic challenges at the molecular level. This research has important implications for personalized medicine approaches to age-related diseases, as it highlights the need to consider gender as a biological variable in therapeutic development. Dr. Balog has supervised numerous graduate students, including Predović Jurica (PhD), Šarić Ana (Master's thesis), and Nikolac Matea (Diploma thesis). His laboratory maintains extensive collaborations both within the Ruđer Bošković Institute and internationally, particularly on projects involving oxidative stress biomarkers, mitochondrial function, and gender-specific responses to environmental stressors. The Laboratory for Metabolism and Aging, under Dr. Balog's leadership, maintains state-of-the-art facilities for studying oxidative stress markers, mitochondrial function, and metabolic pathways. The team employs advanced techniques including molecular biology, biochemistry, and animal models to investigate the complex interplay between metabolism, aging, and stress response. Current projects focus on understanding how SIRT3 mediates sex-specific responses to metabolic challenges and oxidative stress, with potential applications in age-related disease prevention and treatment.

Frank Schroederمشاهده پروفایل

استاد

• Chemical Biology
• Metabolomics
• Analytical Chemistry
• +۳ مورد دیگر

Professor Frank Schroeder is a distinguished scientist at Cornell University and the Boyce Thompson Institute (BTI), holding appointments in both the Department of Chemistry and Chemical Biology and Biochemistry, Molecular and Cell Biology (BMCB) graduate fields. His research focuses on Chemical Biology and Cell Biology , particularly the structural and functional characterization of biogenic small molecules (BSMs) that regulate development, immunity, and inter-organism communication. He leads an interdisciplinary lab with active collaborations across Caltech, Weill Cornell, MIT, and Max Planck Institutes. Key Research Areas: Metabolomics of Caenorhabditis elegans and other nematodes Host-microbiota interactions in mammals Development of NMR/MS-based analytical methodologies Chemical ecology of fungi for antibiotic discovery Scientific Recognition: HHMI Faculty Scholars Program (2016) Daniel F. Klessig Distinguished Scientist title Teaching: Advanced Analytical Chemistry (CHEM6250) at Cornell Focus on NMR and mass spectrometry applications The lab's NMR-driven approaches have uncovered novel BSMs like gluconucleosides, acylspermidines, and ascaroside derivatives, revealing unexpected biosynthetic pathways and conserved functions across species. Recent work includes host-microbe co-metabolism in immune regulation and a groundbreaking click-chemistry enrichment strategy (DIMEN) for metabolome analysis. His team has trained numerous PhD students and postdoctoral researchers, many of whom now hold academic or industry positions.

John Denuمشاهده پروفایل

استاد

• Epigenetics
• Metabolism
• Chromatin Remodeling
• +۷ مورد دیگر

John Denu is a Professor at the University of Wisconsin–Madison leading the Denu Laboratory, which is part of the Microbiome, Epigenetics, and Multi-omics hubs at the Wisconsin Institute for Discovery. His research program investigates the molecular connections between metabolism and epigenetic pathways in human health and age-associated diseases. The lab employs biochemical, genetic, and multi-omics approaches to study chromatin dynamics, utilizing mammalian tissue culture systems and mouse models. Denu's research interests center on understanding how metabolic pathways influence epigenetic regulation. His work focuses on three primary areas: the molecular links between metabolism and epigenetic pathways; the biochemical principles governing epigenetic information written onto histones; and the role of sirtuins in reversible protein acetylation. His lab explores how chromatin remodeling enzymes rely on metabolite-derived co-enzymes, suggesting coordination between nuclear events and metabolic networks. He investigates the hypothesis that chromatin modifying complexes have evolved to sense metabolite levels and respond accordingly. Analysis of his recent publications reveals a strong focus on metabolism-epigenome interactions, with particular emphasis on sirtuins, histone modifications, and the role of specific metabolites like citrate and short-chain fatty acids in regulating chromatin function. His work spans from fundamental biochemical mechanisms to disease-relevant models, particularly in neurodegeneration and aging. Denu mentors several graduate students including Jessica Han (who recently defended her PhD on diet, gut microbiome, and metabolism converging to remodel epigenetics) and Kellen Biesbrock (who joined in 2025). His lab actively collaborates with researchers across campus, including with Prof. Federico E. Rey in the Department of Bacteriology. The Denu Laboratory employs an interdisciplinary approach spanning basic biochemistry to big data, using methods ranging from in vitro enzyme assays to high-throughput mass spectrometry. The lab is actively involved in many collaborations both on and off campus, reflecting the integrative nature of metabolism-epigenome research.