جست‌وجوی استاد و پژوهشگر

Young-Hoon Ahnمشاهده پروفایل

دانشیار

• Chemical Biology
• Cysteine Proteomics
• Redox Signaling
• +۳ مورد دیگر

Young-Hoon Ahn is an Associate Professor in the Department of Chemistry at Drexel University, serving as Chair of the Chemistry Graduate Program Committee. His research focuses on cysteine-based redox signaling in physiology and diseases, particularly using chemical tools to study glutathionylation. He holds a PhD from New York University and has held academic positions at Wayne State University and Drexel University since 2012. Education: PhD (2007, NYU), MS (2001, POSTECH), BS (1999, POSTECH). Postdoctoral training at Johns Hopkins University School of Medicine (2008-2012). Research Interests: Development of chemical probes for glutathione biology, functional studies of protein glutathionylation in cancer and cardiovascular systems, and covalent small-molecule inhibitors targeting cysteine residues. His interdisciplinary approach combines synthetic chemistry, proteomics, bioinformatics, and mouse models. Publications emphasize glutathionylation mechanisms in cellular stress and disease, with recent work on E-cadherin stability, cardiomyocyte biology, and SMYD2 regulation. His lab employs clickable glutathione strategies and bioorthogonal chemistry for redox proteomics.

Keriann M. Backusمشاهده پروفایل

دانشیار

• Analytical Biochemistry
• Biophysics
• Chemical Biology
• +۳ مورد دیگر

Keriann M. Backus is an Associate Professor at the David Geffen School of Medicine , University of California, Los Angeles (UCLA), with a joint appointment in the Department of Chemistry and Biochemistry . Her research focuses on chemical proteomics, cysteine and lysine profiling, and immunomodulatory agents for cancer, infectious, and autoimmune diseases. Education: B.S. in Chemistry and B.A. in Latin American Studies from Brown University (2007), Ph.D. from Oxford University and NIH (2012) Research Interests: She develops chemical tools to study immune system modulation, targeting proteins via small molecules and antibodies. Her work integrates chemical proteomics, activity-based protein profiling (ABPP), and redox biology to explore cell-surface proteomes and inflammation-responsive mitochondrial redoxomes. Article Trends: Recent publications emphasize cysteine chemoproteomics, SP3-FAIMS technology for high-throughput profiling, covalent drug discovery for proteoform-selective inhibitors, proximity labeling for lipid interactomes, and data integration via CysDB. These reflect her expertise in redox-sensitive cysteine mapping and covalent fragment-based screening. Scientific Awards: W.M. Keck Foundation Grant (2024) Ono Breakthrough Science Initiative Award (2023) NIH Director’s New Innovator Award (2021) Packard Fellowship (2020) DARPA Young Faculty Award (2019) Beckman Young Investigator (2019) Rhodes Scholar (2007) NIH Oxford Cambridge Scholar (2007) Advising & Grants: Dr. Backus has secured major grants including the NIH Director’s New Innovator Award and Packard Fellowship. She co-corresponded studies on multi-omic data integration and mentored students in covalent drug discovery and chemoproteomic method development.

• Cancer Metabolism
• Stem Cell Metabolism
• Metabolic Regulation of Cell Growth
• +۵ مورد دیگر

Heather R. Christofk is a Professor in the Department of Biological Chemistry at the David Geffen School of Medicine at UCLA. Her research focuses on the intricate relationship between cellular metabolism and various biological processes, particularly in the contexts of cancer development, stem cell function, and viral infections. Education: PhD in Cell and Developmental Biology from Harvard University (2007) BS in Molecular, Cell, and Developmental Biology from UCLA (2001) Dr. Christofk's research program centers on understanding how metabolic pathways regulate cellular processes in both normal physiology and disease states. Her laboratory has made significant contributions to understanding how cancer cells reprogram their metabolism to support rapid growth and proliferation, with particular focus on glucose metabolism, amino acid utilization, and metabolic adaptations in tumor microenvironments. She has also pioneered work on the metabolic regulation of stem cell function, especially in hair follicle stem cells, demonstrating how metabolic pathways control stem cell activation and differentiation. Her research has important implications for developing novel therapeutic approaches that target cancer metabolism while preserving normal tissue function. Analysis of Dr. Christofk's recent publications reveals a strong focus on metabolic heterogeneity across different biological contexts. Her work spans cancer metabolism (particularly in liposarcoma, melanoma, and hepatocellular carcinoma), stem cell metabolism (especially hair follicle stem cells), viral metabolism (including Epstein-Barr virus and Zika virus), and developmental metabolism (fetal development and organogenesis). A recurring theme is how metabolic pathways serve as regulatory nodes that control cell fate decisions, tumor progression, and therapeutic responses. Selected Research Funding: Metabolic Control of Hair Follicle Stem Cell Homeostasis and Tumorigenesis (NIH R01AR070245, 2018-2023) - Co-Principal Investigator Nutrient regulation of cancer cell growth (NIH R01CA215185, 2017-2022) - Principal Investigator Regulation of the Warburg Effect in Cancer (NIH DP2OD008454, 2011-2016) - Principal Investigator Dr. Christofk's laboratory maintains active collaborations across multiple disciplines, working with clinicians, basic scientists, and computational biologists to address complex questions in metabolism and disease. Her team employs a range of cutting-edge techniques including metabolomics, stable isotope tracing, molecular biology, and in vivo models to investigate metabolic regulation in health and disease.

Richard W. Grossمشاهده پروفایل

استاد

• Analytical Chemistry
• Biological Membranes
• Lipidomics
• +۴ مورد دیگر

Dr. Richard W. Gross is Professor of Medicine and Developmental Biology at Washington University School of Medicine and Professor of Chemistry. He holds a PhD from Washington University, MD from New York University Medical School, and BA from Columbia College. His research focuses on the chemical biology of membranes in health and disease, specializing in lipidomics, metabolomics, and membrane signaling. He pioneered shotgun lipidomics technology for direct identification and quantification of lipid molecular species in biological systems. Developed novel shotgun lipidomics technology combining intrasource separation, multidimensional MS, and array analysis Investigates phospholipase regulation and membrane signaling complexes Studies altered lipid metabolism in obesity, diabetes and cardiovascular disease

Thomas Brunoldمشاهده پروفایل

استاد

• Inorganic Chemistry
• Biochemistry
• Computational Chemistry
• +۵ مورد دیگر

Thomas Brunold is a Professor of Chemistry at the University of Wisconsin–Madison, focusing on the geometric and electronic properties of metal centers in proteins and cofactors . His work integrates spectroscopic techniques (electronic absorption, circular dichroism, magnetic circular dichroism, resonance Raman, electron paramagnetic resonance) with density functional theory (DFT) and quantum mechanics/molecular mechanics (QM/MM) calculations to validate bonding descriptions and explore catalytic intermediates. Bio-organometallic cofactors (adenosylcobalamin, methylcobalamin, NiF430) Metal-dependent superoxide dismutases (Ni-, Fe-, Mn-SODs) Polynuclear NiFeS enzymes (ACS, CODH) His research spans vitamin B12 chemistry , metalloenzyme specificity , and redox-active clusters , with a focus on resolving substrate-bound intermediates and mechanistic debates in catalytic cycles. Recent publications emphasize ligand dynamics , second-sphere residue effects , and metal-cofactor interactions . Scientific awards include the Taylor Teaching Award (2024) , Kellett Mid-Career Award (2020) , and NSF-CAREER Award (2003) . He mentors students in the Brunold Lab, including Ryan Hall , Laura Elmendorf , and Maddy Rodemeier (co-advised with Andrew Buller), with multiple Outstanding TA Awards to lab members.

Jessica D. Rosardaمشاهده پروفایل

استادیار

• Cellular Stress
• Signal Transduction
• Chemical Biology
• +۵ مورد دیگر

Jessica D. Rosarda PhD is an Assistant Professor in the Department of Anatomy, Physiology and Genetics at the Uniformed Services University (USU) of the Health Sciences School of Medicine in Bethesda, MD. She leads a research laboratory focused on cellular stress mechanisms in military-relevant disorders. PhD in Chemical and Biological Sciences, The Scripps Research Institute (2023) MSc in Pharmacy, University of Florida (2013) BSc in Biology, Washington and Lee University (2010) Dr. Rosarda's research centers on cellular stress response pathways, particularly how cells respond to stress through signaling mechanisms that can either protect or damage tissues. Her work spans chemical biology, molecular medicine, neuroscience, and molecular/cell biology with a focus on proteostasis, unfolded protein response, and stress signaling dynamics in disease contexts. She investigates how imbalances in these pathways contribute to conditions ranging from retinal degeneration to traumatic brain injury, with particular relevance to military medicine. Analysis of Dr. Rosarda's publication record reveals a strong focus on stress response pathways, particularly the unfolded protein response and integrated stress response. Her work demonstrates how perturbations in proteostasis contribute to diverse pathologies including neurodegeneration, amyloidosis, and inflammatory conditions. She employs chemical biology approaches to develop therapeutic strategies targeting these pathways, with several publications on pharmacological modulators of stress responses. Dr. Rosarda maintains an active research program with numerous publications in high-impact journals including Nature Communications, Cell Chemical Biology, and ACS Chemical Biology. Her work frequently involves collaborations with the Wiseman laboratory and other researchers in the fields of proteostasis and stress response. Dr. Rosarda's laboratory at USU focuses on defining stress pathway signaling dynamics in military-relevant disorders, determining the metabolic factors that govern these stress responses, and identifying novel approaches for resolving toxic stress involved in both acute and chronic conditions.

• Organic Chemistry
• Chemical Biology
• Peptide and Protein Synthesis
• +۵ مورد دیگر

Professor Richard J. Payne (FAA, FRSC, FRSN, FRACI) is the NHMRC Investigator Leadership Fellow and Deputy Director of the ARC Centre of Excellence for Innovations in Peptide and Protein Science at The University of Sydney. He earned a BSc (1st class honours) from the University of Canterbury (2002) and a PhD from the University of Cambridge under the late Professor Chris Abell (2003-2007). After postdoctoral work at The Scripps Research Institute with Professor Chi-Huey Wong (2007-2008), he joined The University of Sydney as a Lecturer in Organic Chemistry. His research focuses on chemical synthesis of biomolecules to address biological and medical challenges, particularly in anti-infectives , vaccine development , and glycopeptide engineering . His lab pioneered diselenide-selenoester ligation and selenocysteine-based modification techniques for constructing complex peptides and proteins. Current projects target pathogens like Mycobacterium tuberculosis , Plasmodium falciparum , and SARS-CoV-2 through inhibitor design , anticoagulant discovery , and LYTAC development . His 15 most recent publications span 2025-2021 and reflect multidisciplinary work at the chemistry-biology interface , including antiviral peptides , glycoprotein assembly , and supramolecular anticoagulants . Notably, 2025 articles address C-terminal bromodomain inhibitors and on-demand reversible anticoagulants , while 2024 studies focus on PROTAC-based proteostasis disruption and mycobacterial chaperone targeting . Awards & Honors 2016 Malcolm McIntosh Prime Minister's Prize 2023 Australian Academy of Science Fellowship 2014 Le Fèvre Memorial Prize & Edgeworth David Medal 2018 A.J. Birch Medal He supervises 8 active research students and leads collaborations with The Payne Research Group , Charles Perkins Centre , and Sydney Nano Institute . His work aligns with the University of Sydney's research strengths in Molecules to Materials and Next Generation Therapeutics .

Edward J. Craneمشاهده پروفایل

استاد

• Microbial Respiration
• Anaerobic Respiration
• Sulfur Respiration
• +۶ مورد دیگر

Edward J. Crane is a Professor of Biology and Chair of the Biology Department at Pomona College, where he has held faculty positions since 2002. His laboratory (Seaver Biology 14) and office (Seaver Biology 21) are central to his research on microbial respiration in extreme environments, with expertise spanning biochemistry, enzymology, and extremophile microbiology. Education: Ph.D. in Classics and Critical Theory, University of Washington, 2002 Crane specializes in anaerobic respiration mechanisms, particularly sulfur- and iron-based processes in acid hot springs, deep-sea sediments, petroleum reservoirs, and hydrothermal vents. His work integrates mechanistic enzymology, microbial community analysis, and geochemical impacts, with significant focus on hyperthermophiles like Pyrococcus species. Key research themes include coenzyme A metabolism in thermophiles, oxidative stress protection systems, and the role of microbial respiration in astrobiology. His publication record (2000-2006) reveals consistent focus on enzymatic disulfide metabolism in extremophiles, with recurring investigations of NADH oxidases/peroxidases and coenzyme A reductases across Borrelia and archaeal models. These studies bridge biochemistry, microbiology, and earth sciences, demonstrating how microbial redox processes shape extreme environments. Scientific recognition includes: Wig Distinguished Professorship for Teaching Excellence (Pomona, 2005) Two Cottrell College Science Awards (Research Corporation, 2000-2005) National Institutes of Health National Research Service Award (1994-1996) Salisbury University Distinguished Faculty Award (1999) Johns Hopkins University Harry D. Kruse Award (1992) Crane has secured major research funding including $55,000 from ACS Petroleum Research Fund (2007-2010), DOE Genomes to Life Initiative participation (2007-), $235,780 NSF instrumentation grant (2003-2006), and HHMI undergraduate education support (2003-2006). He teaches Advanced Biochemistry and laboratory courses while mentoring independent studies in biochemistry and chemistry. His Seaver Biology 14 laboratory operates within Pomona College's molecular biology research infrastructure, collaborating with institutions including University of Washington and Johns Hopkins University on projects like the DOE's Shewanella ecophysiology studies.

• Plant Physiology
• Biochemistry
• Redox Regulation
• +۵ مورد دیگر

Prof. Dr. Karl-Josef Dietz holds a Professorial Chair (C4) in Biochemistry and Physiology of Plants at the Faculty of Biology, Bielefeld University since 1997. He is Head of the working group 'Biochemistry and Physiology of Plants' at the Center for Biotechnology (CeBiTec). His academic career spans prestigious institutions including Julius-Maximilians-Universität Würzburg (where he completed his PhD and Habilitation), Harvard University (postdoc position), and numerous international research stays in France, Japan, and the USA. Prof. Dietz's research focuses on plant stress responses, redox regulation, and photosynthesis. His work explores how plants acclimate to multiple environmental stresses through molecular signal integration, with particular emphasis on reactive oxygen species (ROS) signaling, thiol peroxidases, and oxylipin pathways. His laboratory investigates the mechanisms of redox regulation in chloroplasts and mitochondria, stress sensing, and plant defense responses against pathogens and abiotic challenges. His recent publications reveal a strong focus on redox biology, stress acclimatization mechanisms, and the role of peroxiredoxins in plant stress responses. His work spans both fundamental biochemical investigations and applied research in plant protection and stress tolerance. Scientific Awards and Recognition: Science Prize of the University Foundation Würzburg (1985) Gay-Lussac-Humboldt Prize (2012) Prof. Dietz has served in numerous leadership roles including Dean of the Faculty of Biology (2004-2006), President of the German Botanical Society (2012), and as a member of the Science Board of the German Research Foundation (DFG). He serves on the editorial boards of several prestigious journals including Journal of Experimental Botany, Physiologia Plantarum, and Plant Physiology. His professional activities demonstrate extensive involvement in national and international scientific communities, including the German Society of Botany, the American Society of Plant Biologists, and the Federation of European Societies of Plant Biology.

Kate S. Carrollمشاهده پروفایل

استاد

• Chemical Biology
• Redox Proteomics
• Chemoproteomics
• +۶ مورد دیگر

Dr. Kate S. Carroll is Professor of Chemistry and Biochemistry at Florida Atlantic University, leading research at the intersection of chemical biology and redox proteomics with significant implications for cancer and neurodegenerative disease therapeutics. Education: Ph.D. in Chemistry, Stanford University (2003) Her research program focuses on decoding biological systems through chemical tools, specializing in cysteine redox signaling mechanisms. The Carroll Laboratory develops chemoproteomic platforms to map the "redoxome," designs reaction-based probes for detecting protein modifications like sulfenic acids, and identifies cysteine-based therapeutic targets. Key disease applications include cancer progression, neurodegenerative disorders, and antiviral strategies against pathogens like SARS-CoV-2 through spike protein disulfide disruption. Analysis of her 2021-2024 publications reveals a dominant trajectory in sulfur/selenium chemical biology with increasing translational emphasis. Her work consistently bridges fundamental redox chemistry with disease mechanisms, particularly in covalent ligand discovery for the cysteine redoxome and development of fluorogenic probes for live-cell oxidation tracking. The 2022 SARS-CoV-2 study exemplifies her lab's pivot toward urgent therapeutic applications. Major scientific recognition includes: Pfizer Award in Enzyme Chemistry (2013) Camile Dreyfus Teacher-Scholar Award (2010) Fellow of the Royal Society of Chemistry (2022) Dr. Carroll actively shapes her field through editorial leadership as Associate Editor of Free Radical Biology and Medicine (2021-present) and governance roles including Chair of the ACS Division of Biological Chemistry Program Committee (2024) and leadership in Gordon Research Conferences on redox biology. Her laboratory supports undergraduate independent research and graduate training in chemical biology methodology development. The Carroll Laboratory operates as an integrated chemical biology hub at FAU, combining proteomics, organic synthesis, and cellular assays to investigate thiol-based redox regulation across disease contexts while developing covalent therapeutics and diagnostic probes.

Carolyn Sevierمشاهده پروفایل

استاد

• Biochemistry
• Genetics
• Cell Biology
• +۲ مورد دیگر

Carolyn Sevier is a Professor in the Department of Molecular Medicine at Cornell University's College of Veterinary Medicine. She leads a research laboratory focused on redox signaling and protein homeostasis, with affiliations to the Biochemistry, Molecular, and Cell Biology (BMCB) and Biomedical & Biological Sciences (BBS) PhD programs. Dr. Sevier mentors graduate students and postdoctoral researchers, providing guidance through Cornell's structured academic pathways. Research Focus Her work spans redox regulation mechanisms in the endoplasmic reticulum, protein folding, and cellular stress responses. Key areas include: Thiol-based redox signaling pathways Chaperone-mediated protein homeostasis Interorganelle communication (ER-mitochondria) Oxidative stress adaptation Disulfide bond formation/reduction Publication Trends Recent articles (2016-2024) demonstrate a consistent focus on endoplasmic reticulum redox dynamics, chaperone functions (BiP/Hsp70), and stress response mechanisms. Work integrates yeast genetics, mammalian models, and biochemical approaches to explore fundamental cellular processes with implications for metabolic and degenerative diseases. Academic Training Dr. Sevier actively advises graduate students through Cornell's BMCB and BBS programs and recruits postdoctoral scholars. Her laboratory provides training in biochemical, genetic, and cell biological techniques for studying redox biology.

Richard F. Loeser, Jr.مشاهده پروفایل

استاد

• Osteoarthritis (OA) mechanisms
• Cartilage cell biology
• Redox regulation of cell signaling
• +۴ مورد دیگر

Dr. Richard F. Loeser, Jr. is the Joseph P. Archie, Jr. Eminent Professor of Medicine and Director of the UNC Thurston Arthritis Research Center at the University of North Carolina School of Medicine. His research focuses on osteoarthritis (OA) mechanisms, particularly the role of oxidative stress, aging, and cellular signaling in joint degeneration. He has pioneered studies on redox regulation of chondrocyte signaling and integrin function, using both in vitro and rodent models. Education: Undergraduate: Virginia Tech Medical School: West Virginia University Residency/Fellowship: Wake Forest Baptist Medical Center Research interests include OA biomarkers, exercise interventions, and gut microbiota's role in joint health. His clinical work emphasizes translating basic science discoveries into therapeutic strategies, including weight loss and exercise programs for knee OA patients. He leads multidisciplinary teams studying OA phenotypes and metabolomics. Publications reflect a blend of clinical trials (e.g., START trial on strength training) and mechanistic studies on cellular senescence and Sirt6 pathways. He holds leadership roles in arthritis research and has contributed to major reviews defining OA as a systemic joint disease.

• Proteomics
• Metabolomics
• Plant-Microbe Interactions
• +۳ مورد دیگر

Prof. Dr. Karsten Niehaus serves as Head of the Proteome and Metabolome Research Group at the Center for Biotechnology (CeBiTec) and Faculty of Biology, University of Bielefeld. His research focuses on proteomics and metabolomics applications in plant-microbe interactions, bacterial stress responses, and disease model systems. His laboratory employs advanced mass spectrometry imaging and cell phenotyping technologies to investigate molecular responses in crops like sugar beet and grapevines under abiotic stress conditions, as well as in cancer models where differentiation therapy impacts tumor malignancy. The group also explores microbial biotechnology through Xanthomonas campestris studies on xanthan production and stress adaptation. Selected publications highlight innovations in 3D microfluidics for biomarker detection and bioinformatics platforms like MetHoS for metabolomics data analysis. His work appears in journals covering Frontiers in Plant Science , Scientific Reports , and Journal of Experimental Botany . Contact: kniehaus@cebitec.uni-bielefeld.de | Office: UHG W7-117

Betty Leiboldمشاهده پروفایل

استاد

• Iron Metabolism
• Cellular Iron Regulation
• Iron Regulatory Proteins
• +۳ مورد دیگر

Betty Leibold is a Professor at the University of Utah in the Department of Internal Medicine . Her research focuses on iron metabolism , diabetes , and mitosis , with a particular emphasis on iron regulatory proteins (IRPs) and their role in cellular homeostasis. Education: B.S., State University of New York Ph.D., Massachusetts Institute of Technology Research Interests include understanding how eukaryotic cells sense and respond to iron, the mechanisms of IRP2 regulation via ubiquitin ligases and phosphorylation, and the link between iron dysregulation and diseases like diabetes and neurodegenerative disorders. Her lab employs Caenorhabditis elegans and transgenic mice models to study these pathways. Publications highlight her work on IRP2's role in iron-dependent tRNA modification, HIF-1 regulation of iron homeostasis in worms, and the molecular mechanisms of IRP2 degradation. Keywords span iron metabolism , protein regulation , cell signaling , genetic models , and disease pathogenesis .

Julea Buttمشاهده پروفایل

استاد

• Biophysical Chemistry
• Microbial Electron Transfer
• Photocatalysis
• +۳ مورد دیگر

Professor Julea Butt is a leading academic in Biophysical Chemistry at the University of East Anglia’s School of Biological Sciences. She specializes in microbial electron transfer mechanisms, biohybrid materials, and photocatalytic systems. Her research focuses on engineering proteins like multiheme cytochromes for applications in sustainable energy and environmental biotechnology. Member of multiple research centers including the Centre for Molecular and Structural Biochemistry and the Wolfson Centre for Advanced Environmental Microbiology. Expertise spans protein structure-function relationships, nanomaterial integration with biological systems, and light-driven catalytic processes. Research interests include: Design of bioelectronic interfaces for solar fuels production Electron transport in bacterial outer membrane proteins Development of semi-artificial photosynthetic systems Mechanistic studies of cytochrome-mediated redox reactions Recent work highlights include: Engineering bespoke biomolecular wires for transmembrane electron transfer Photocatalytic nitrous oxide removal using liposomal microreactors Genetic code expansion for protein functionalization in Shewanella Her lab collaborates on projects involving microbial electron transfer, biohybrid nanomaterials, and sustainable biocatalytic systems. She is actively supervising PhD students in these areas and has published over 130 peer-reviewed articles.