Jessica D. Rosarda

Jessica D. Rosarda PhD is an Assistant Professor in the Department of Anatomy, Physiology and Genetics at the Uniformed Services University (USU) of the Health Sciences School of Medicine in Bethesda, MD. She leads a research laboratory focused on cellular stress mechanisms in military-relevant disorders.

• PhD in Chemical and Biological Sciences, The Scripps Research Institute (2023)
• MSc in Pharmacy, University of Florida (2013)
• BSc in Biology, Washington and Lee University (2010)

Dr. Rosarda's research centers on cellular stress response pathways, particularly how cells respond to stress through signaling mechanisms that can either protect or damage tissues. Her work spans chemical biology, molecular medicine, neuroscience, and molecular/cell biology with a focus on proteostasis, unfolded protein response, and stress signaling dynamics in disease contexts. She investigates how imbalances in these pathways contribute to conditions ranging from retinal degeneration to traumatic brain injury, with particular relevance to military medicine.

Analysis of Dr. Rosarda's publication record reveals a strong focus on stress response pathways, particularly the unfolded protein response and integrated stress response. Her work demonstrates how perturbations in proteostasis contribute to diverse pathologies including neurodegeneration, amyloidosis, and inflammatory conditions. She employs chemical biology approaches to develop therapeutic strategies targeting these pathways, with several publications on pharmacological modulators of stress responses.

Dr. Rosarda maintains an active research program with numerous publications in high-impact journals including Nature Communications, Cell Chemical Biology, and ACS Chemical Biology. Her work frequently involves collaborations with the Wiseman laboratory and other researchers in the fields of proteostasis and stress response.

Dr. Rosarda's laboratory at USU focuses on defining stress pathway signaling dynamics in military-relevant disorders, determining the metabolic factors that govern these stress responses, and identifying novel approaches for resolving toxic stress involved in both acute and chronic conditions.