Niladri Sinha

Niladri Sinha is an Assistant Professor in the Department of Biochemistry at the University of Utah, specializing in ribosome biology and translational control mechanisms. His research bridges molecular biology and cellular stress response pathways.

• Education: M.Sc. from University of Calcutta, Ph.D. from University of Utah
• Affiliations: Member of the Molecular Biology Program and Biological Chemistry Program at University of Utah

Research focuses on ribosomes as cellular stress sensors, investigating ribosomal collision detection, proteostasis regulation, and stress response pathways. His lab identifies quality control factors and signaling mechanisms that maintain translational homeostasis under stress conditions.

Recent work established the ribotoxic stress response as a primary determinant of UV-induced cell fate decisions (Cell 2024). His team discovered EDF1 as a critical early responder to ribosomal collisions (eLife 2020) and characterized pathways linking translational stress to apoptosis and disease pathogenesis.

Publications reveal expertise in ribosome-associated quality control, RNA degradation, and translation regulation. Studies span fundamental mechanisms in RNA biology and stress response pathways, with implications for cancer, aging, and neurodegenerative disorders.

Laboratory research combines biochemical, proteomic, cryo-EM, and genetic approaches to characterize ribosome-mediated stress responses. Future work aims to exploit translational vulnerabilities in cancer cells and aging-related proteostasis defects.