Kate S. Carroll

Dr. Kate S. Carroll is Professor of Chemistry and Biochemistry at Florida Atlantic University, leading research at the intersection of chemical biology and redox proteomics with significant implications for cancer and neurodegenerative disease therapeutics.

Education:

• Ph.D. in Chemistry, Stanford University (2003)

Her research program focuses on decoding biological systems through chemical tools, specializing in cysteine redox signaling mechanisms. The Carroll Laboratory develops chemoproteomic platforms to map the "redoxome," designs reaction-based probes for detecting protein modifications like sulfenic acids, and identifies cysteine-based therapeutic targets. Key disease applications include cancer progression, neurodegenerative disorders, and antiviral strategies against pathogens like SARS-CoV-2 through spike protein disulfide disruption.

Analysis of her 2021-2024 publications reveals a dominant trajectory in sulfur/selenium chemical biology with increasing translational emphasis. Her work consistently bridges fundamental redox chemistry with disease mechanisms, particularly in covalent ligand discovery for the cysteine redoxome and development of fluorogenic probes for live-cell oxidation tracking. The 2022 SARS-CoV-2 study exemplifies her lab's pivot toward urgent therapeutic applications.

Major scientific recognition includes:

• Pfizer Award in Enzyme Chemistry (2013)
• Camile Dreyfus Teacher-Scholar Award (2010)
• Fellow of the Royal Society of Chemistry (2022)

Dr. Carroll actively shapes her field through editorial leadership as Associate Editor of Free Radical Biology and Medicine (2021-present) and governance roles including Chair of the ACS Division of Biological Chemistry Program Committee (2024) and leadership in Gordon Research Conferences on redox biology. Her laboratory supports undergraduate independent research and graduate training in chemical biology methodology development.

The Carroll Laboratory operates as an integrated chemical biology hub at FAU, combining proteomics, organic synthesis, and cellular assays to investigate thiol-based redox regulation across disease contexts while developing covalent therapeutics and diagnostic probes.