معرفی
Professor Richard J. Payne (FAA, FRSC, FRSN, FRACI) is the NHMRC Investigator Leadership Fellow and Deputy Director of the ARC Centre of Excellence for Innovations in Peptide and Protein Science at The University of Sydney. He earned a BSc (1st class honours) from the University of Canterbury (2002) and a PhD from the University of Cambridge under the late Professor Chris Abell (2003-2007). After postdoctoral work at The Scripps Research Institute with Professor Chi-Huey Wong (2007-2008), he joined The University of Sydney as a Lecturer in Organic Chemistry.
His research focuses on chemical synthesis of biomolecules to address biological and medical challenges, particularly in anti-infectives, vaccine development, and glycopeptide engineering. His lab pioneered diselenide-selenoester ligation and selenocysteine-based modification techniques for constructing complex peptides and proteins. Current projects target pathogens like Mycobacterium tuberculosis, Plasmodium falciparum, and SARS-CoV-2 through inhibitor design, anticoagulant discovery, and LYTAC development.
His 15 most recent publications span 2025-2021 and reflect multidisciplinary work at the chemistry-biology interface, including antiviral peptides, glycoprotein assembly, and supramolecular anticoagulants. Notably, 2025 articles address C-terminal bromodomain inhibitors and on-demand reversible anticoagulants, while 2024 studies focus on PROTAC-based proteostasis disruption and mycobacterial chaperone targeting.
Awards & Honors
- 2016 Malcolm McIntosh Prime Minister's Prize
- 2023 Australian Academy of Science Fellowship
- 2014 Le Fèvre Memorial Prize & Edgeworth David Medal
- 2018 A.J. Birch Medal
He supervises 8 active research students and leads collaborations with The Payne Research Group, Charles Perkins Centre, and Sydney Nano Institute. His work aligns with the University of Sydney's research strengths in Molecules to Materials and Next Generation Therapeutics.
