جست‌وجوی استاد و پژوهشگر

Peng Yaoمشاهده پروفایل

دانشیار

• RNA Biology
• Translational Control
• Cardiovascular Disease
• +۷ مورد دیگر

Peng Yao, Ph.D. is an Associate Professor at the University of Rochester Medical Center with dual appointments in the Department of Medicine (Aab Cardiovascular Research Institute) and the Department of Biochemistry and Biophysics (School of Medicine and Dentistry). His laboratory focuses on RNA biology and translational control mechanisms in cardiac health and disease. Education: Bachelor of Science in Biotechnology from Wuhan University (2003) Ph.D. in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science (2008) Post-doctoral training under Dr. Paul Fox at Lerner Research Institute of Cleveland Clinic (2008-2012) Dr. Yao's research program centers on understanding pathophysiological functions and regulatory mechanisms of non-coding RNAs and RNA-binding proteins in the cardiac system and cardiovascular disorders. His laboratory investigates translational control mechanisms in cardiac health and disease, riboswitch-like RNA switch mechanisms of gene regulation in mammalian systems, and the role of translation machinery in cardiovascular system. The lab employs various approaches including biochemistry and biophysics, molecular and cellular biology, genetic and surgical mouse models, and high throughput technologies combined with bioinformatic tools to dissect regulatory pathways. Recent discoveries include a new type of stress-responsive, protein-directed human RNA switch that regulates VEGFA expression and a novel mRNA processing mechanism that expands the human proteome. Analysis of Dr. Yao's recent publications reveals a strong thematic focus on translational control mechanisms in cardiac pathophysiology. His work spans fundamental molecular mechanisms to potential therapeutic applications, with particular emphasis on RNA-binding proteins, mitochondrial translation, RNA structural elements regulating translation, and novel therapeutic targets for cardiac fibrosis and hypertrophy. The research demonstrates translational relevance with connections to drug development, particularly in targeting fibrosis-related diseases including heart failure. Scientific Awards: American Heart Association (AHA) Established Investigator Award (2024) Harold S. Geneen Charitable Trust Award (2023) Poster Competition Award at the 4th ACRE-APS Symposium at BCVS (2022) University of Research Award (2022) LeapRx Program Award (2022) Rubens Discovery Award (2021) Dr. Yao actively mentors postdoctoral scholars, research staff, and graduate students in his laboratory. His research program is supported by NIH funding for translational control of human health and disease, as well as industry funding from Novo Nordisk to develop novel RNA-based drugs for treating fibrosis-related human diseases including heart failure, liver stenosis, and cancer. The Yao Laboratory employs a comprehensive methodology including in vitro translation systems, polysome profiling coupled with RNA-Seq, RiboTag-Seq, ribosome profiling, protein-RNA interaction assays, and various mouse models of heart failure to investigate translational control mechanisms in the cardiac system.

Eric M. Smallمشاهده پروفایل

دانشیار

• Cardiac fibrosis
• Transcriptional regulation
• Cardiac development
• +۴ مورد دیگر

Eric M. Small, Ph.D. is Associate Professor of Medicine at the University of Rochester School of Medicine and Dentistry, with secondary appointments in Biomedical Engineering and Pharmacology and Physiology. He directs the Small Lab at the Aab Cardiovascular Research Institute, where his research focuses on transcriptional regulation of cardiac development, disease mechanisms, and regenerative potential. Dr. Small received his formal education through: B.S. in Cellular and Molecular Biology from the University of Michigan (1995) Ph.D. in Molecular Biology from the University of Texas at Austin under Dr. Paul Krieg (2003) Postdoctoral training at UT Southwestern Medical Center with Dr. Eric Olson (2005-2011) Additional postdoctoral work at Hospital for Sick Children, Toronto with Dr. Benoit Bruneau (2004-2005) His laboratory investigates two primary research themes: (1) cardiac fibroblast plasticity and pathological fibrosis development following cardiac injury, using gene expression profiling in animal models and human samples to identify novel fibrosis regulators; and (2) epicardium-derived progenitor cell mobilization during development and potential regenerative applications, with focus on mechanosensitive gene programs essential for cell migration and differentiation. The lab employs mouse genetics, cell biology, advanced imaging, and bioinformatic approaches to develop therapeutic strategies targeting cardiac scarring and heart failure progression. Analysis of Dr. Small's recent publications reveals strong focus on transcriptional regulation of fibrosis, cardiac remodeling mechanisms, and novel therapeutic targets. His work spans molecular mechanisms of fibroblast activation, nuclear envelope integrity in cardiomyopathies, and high-throughput screening for antifibrotic compounds, demonstrating consistent trajectory toward understanding and intervening in pathological cardiac remodeling processes. Scientific Recognition Established Investigator Award (2023) Excellence in Postdoctoral Mentoring Award (2013) Scientist Development Grant (2010-2014) Ruth L. Kirschstein NRSA Post-Doctoral Fellowship (2004-2007) Best Poster Presentation Award (2002) Dr. Small has successfully mentored numerous graduate students and postdoctoral scholars, many of whom now hold faculty positions or industry roles. His laboratory receives support from multiple NIH training grants including T32 programs in Cellular, Biochemical & Molecular Sciences and Immunology. Current research directions include exercise-induced cardioprotection, PKP2-related arrhythmogenic cardiomyopathy mechanisms, and Sprr2b regulation of fibroblast plasticity. The Small Lab maintains active collaborations within the University of Rochester Medical Center and with external institutions, operating within the Aab Cardiovascular Research Institute infrastructure with access to advanced imaging, genomics, and preclinical testing facilities. The lab's research directly contributes to understanding fundamental cardiac biology while developing translational approaches for treating heart failure and fibrosis.

• cGMP signaling
• Signal transduction
• Transgenic mouse models
• +۳ مورد دیگر

Professor Robert Feil leads the Department of Signal Transduction & Transgenic Models at the Interfaculty Institute for Biochemistry , University of Tübingen. His research focuses on cGMP signaling pathways across cardiovascular, neurological, and cancer contexts, utilizing "in vivo biochemistry" and advanced optical imaging technologies in transgenic mouse models. Current affiliations: Spokesperson for DFG Research Training Group GRK 2381 (2019-present) and member of GRK 2816 Research highlights: Mechanosensitive cGMP signaling, tumor-vascular interactions, CNP/GC-B signaling in kidney development, and novel insights into atherosclerosis mechanisms Recent work emphasizes cell fate mapping through CreER technology and real-time cGMP visualization in living systems. His lab has produced significant findings on vascular smooth muscle cell plasticity and macrophage-like cell transdifferentiation in atherosclerotic plaques. Key trainees include: PhD candidates: Kevin Dervishi (mechanosensitive signaling), Alisa Groh (tumor vessel signaling), Shahzad Munir (hippocampal signaling), Daniel Pinto Quintero (platelet signaling), and Asli Pektas (developmental physiology) Past doctoral researchers: Timo Kopp (2024 graduate), Daniel Stehle (2023 graduate) Technological innovations: Developed CreER T2 for inducible gene targeting Created cGMP biosensors for in vivo imaging

Hao Liمشاهده پروفایل

استادیار

• Medical Image Analysis
• Artificial Intelligence in Pathology
• Deep Learning for Medical Imaging
• +۳ مورد دیگر

Hao Li is an Assistant Professor at Vanderbilt University , affiliated with the Vanderbilt School of Engineering and the Medical Image Computing Laboratory (MedICL) . He holds a PhD in Computer Science (2024) with a dissertation titled From Data-driven to Data-centric Medical Image Segmentation , advised by Ipek Oguz. Education: PhD, Computer Science, Vanderbilt University (2024) Li’s research focuses on Medical Image Analysis , particularly in digital pathology and spatial transcriptomics . His work bridges deep learning with renal pathology , emphasizing data-centric approaches for improved segmentation and disease modeling. His recent publications highlight advancements in glomerular segmentation , cross-species data integration , and AI foundation models for kidney pathology. Technologies like MagNet (multi-level attention graph networks) and PySpatial (high-speed pathomics toolkit) underscore his contributions to computational biology and medical imaging . Grants & Workshops: NIH Grant Writing Workshops (2022-2023) Li’s affiliations include the VISE Partners program and the Medical Innovators Development Program (MIDP) , reflecting collaborations between Vanderbilt School of Engineering and Vanderbilt School of Medicine . His lab, MedICL , drives interdisciplinary research in medical image computing and AI-driven diagnostics .

• RGS Proteins
• G Protein Signaling
• Neurodegenerative Diseases
• +۴ مورد دیگر

Rory Fisher is a Professor of Neuroscience and Pharmacology at the University of Iowa, serving as Director of Graduate Studies in the Department of Neuroscience and Pharmacology. His research focuses on molecular mechanisms of RGS proteins in G protein signaling, neurodegenerative diseases, cancer biology, and cardiovascular development. He holds a PhD in Molecular, Cellular, and Developmental Biology from Iowa State University and completed postdoctoral training in Pathology and Biochemistry at the University of Texas Health Science Center. Education: Bachelor of Science in Biology, Texas A&M University PhD in Molecular, Cellular, and Developmental Biology, Iowa State University Postdoctoral Fellowships at University of Texas Health Science Center (Pathology & Biochemistry) His research investigates how RGS proteins regulate cellular processes, including their roles in Parkinson’s disease, cancer suppression, and placental dysfunction in preeclampsia. His lab has identified RGS6 as a tumor suppressor and a key mediator of dopamine signaling in addiction and motor control. His work bridges molecular biology, pharmacology, and translational medicine, with implications for therapies targeting neurodegenerative and cardiovascular disorders. Current projects include studying RGS6’s nuclear functions, its role in alcohol reward pathways, and developing inhibitors for RGS proteins. His lab collaborates with institutions globally and contributes to training programs in pharmacological sciences.

Dongmin Liuمشاهده پروفایل

استاد

• Metabolic Health
• Nutrition Science
• Diabetes Prevention
• +۴ مورد دیگر

Dongmin Liu, PhD is a Professor in the Department of Human Nutrition, Foods, and Exercise at Virginia Tech, affiliated with the College of Agriculture and Life Sciences. He holds a PhD in Animal Nutrition and Physiology from Virginia Tech (2000) and has been a faculty member since 2004, advancing from Assistant to Associate Professor before becoming a full Professor in 2015. His research focuses on bioactive compounds for metabolic health, including identifying phytochemicals that delay aging and prevent obesity/diabetes. Dr. Liu’s work utilizes rodent models and tissue culture techniques to study glucose/lipid metabolism, pancreatic islet function, and cellular signaling pathways. Key achievements include discovering kaempferol’s role in insulin sensitivity and genistein’s protective effects on pancreatic β-cells. He has authored over 80 peer-reviewed articles and serves on editorial boards of journals like Frontiers in Nutrition and Molecular Nutrition and Food Research . Research interests span two core areas: 1) bioactive compound identification for diabetes prevention and 2) nutraceutical development for longevity. His lab employs immunohistochemistry, biochemical assays, and metabolic phenotyping. Awards include multiple Research Excellence Awards from Virginia Tech and a Postdoctoral Fellowship from the American Heart Association. Dr. Liu’s presentations include talks on plant-derived small molecules at international conferences like the World Congress on Foods and Nutrition. He collaborates with institutions globally, including Henan University (China) and Xi’an Jiaotong-Liverpool University. His future work emphasizes translating findings into clinical applications for metabolic disorders.

Yide Zhangمشاهده پروفایل

استادیار

• Photoacoustic Imaging
• Quantum Imaging
• Ultrafast Imaging
• +۴ مورد دیگر

Yide Zhang is an Assistant Professor of Electrical, Computer & Energy Engineering (ECEE) and Biomedical Engineering (BME) at the University of Colorado Boulder. His research focuses on pioneering optical imaging technologies, including photoacoustic imaging, quantum imaging, and ultrafast imaging, aiming to advance translational research in biomedical diagnostics and engineering. He holds a Ph.D. in Electrical Engineering from the University of Notre Dame and a B.Eng. in Automation from Huazhong University of Science and Technology. His postdoctoral work at Caltech expanded his expertise into quantum imaging and ultrafast phenomena visualization. Key achievements include developing the first Poisson-Gaussian denoising dataset for fluorescence microscopy and pioneering non-invasive photoacoustic imaging techniques. His work has been recognized with awards such as the Seno Medical Best Paper Award and NIH K99/R00 funding. Research interests span: photoacoustic imaging for hemodynamics, quantum imaging via entangled photons, ultrafast imaging of biological and physical processes, fluorescence lifetime imaging, and machine learning applications in microscopy. He leads the Boulder Optical Laboratory for Translational Science (BOLTS), which bridges foundational science with clinical solutions. Major grants include NIH support for developing optical imaging technologies. Notable publications include work in Nature Biomedical Engineering , Science Advances , and Optica . He actively mentors postdocs and students in interdisciplinary research areas such as optics, machine learning, and biomedical engineering.

Brian L. Linمشاهده پروفایل

استادیار

• Muscular Dystrophy
• Cardiac Dysfunction
• Mechanical Signaling
• +۵ مورد دیگر

Brian L. Lin, PhD is an Assistant Professor in the Department of Cell Biology, Neurobiology, and Anatomy at the Medical College of Wisconsin. His research focuses on mechanical signaling in the heart within muscular dystrophy contexts, addressing cardiac dysfunction which is a leading cause of mortality in these diseases. He holds a PhD from Loyola University (2016) and a BS from Miami University (2008), with postdoctoral training at Johns Hopkins Medical Institutions (2016-2023). Education : BS, Miami University, 2008 PhD, Loyola University, 2016 Postdoctoral Fellow, Johns Hopkins Medical Institutions, 2023 Research Focus : The Lin Lab employs spatial transcriptomics, animal models, single-cell biomechanics, and nanoparticle drug delivery to develop therapies targeting TRP channels in dystrophic cardiomyopathy. Key areas include cardiac mechanical signaling, TRPC6 channel inhibition, and stem cell engineering for regenerative medicine. Publications : Recent work emphasizes drug discovery (e.g., ruxolitinib repurposing), gene therapy limitations, cadmium toxicity effects, and TRP channel pharmacology. Publications span Science Translational Medicine , Cell Reports , and iScience . Awards : K99/R00 Award (TRPC6 in Duchenne Muscular Dystrophy) Lab & Collaborations : The lab integrates multi-omics approaches with preclinical testing platforms. Current projects explore novel therapies using in silico drug discovery and human stem cell models. Follow @iheartlinlab for updates.

Velia Fowlerمشاهده پروفایل

استاد

• Cellular Architecture
• Cytoskeleton Biology
• Actin Filament Dynamics
• +۳ مورد دیگر

Velia Fowler is a Professor and Chair of the Department of Biological Sciences at the University of Delaware. She holds a B.A. from Oberlin College and a Ph.D. from Harvard University, followed by postdoctoral research at the National Institutes of Health and Johns Hopkins University. Her research focuses on cellular architecture, particularly the role of the actin cytoskeleton in determining cell shape, mechanical properties, and physiological functions across systems such as red blood cells, eye lenses, and musculoskeletal tissues. Her lab employs advanced techniques including super-resolution microscopy, mouse genetics, and computational modeling to study actin dynamics. Key projects include understanding red blood cell shape maintenance via myosin interactions, erythroblast enucleation mechanisms, and lens biomechanics. Dr. Fowler has been recognized with prestigious awards, including the 2023 AAAS Lifetime Fellowship and American Society of Cell Biologists (ASCB) Fellow distinction. Research Interests: Cytoskeletal regulation, actomyosin networks, erythropoiesis, eye lens biology Lab Location: Wolf Hall (Offices 118, Lab 341) Collaborations: Delaware Center for Musculoskeletal Research, computational biologists, and geneticists Her work bridges fundamental cell biology with clinical relevance, addressing conditions like cardiomyopathy, cataracts, and anemias. Recent studies include identifying TMOD1 mutations linked to childhood heart disease and elucidating Tensin1's role in erythroblast enucleation.

Alli Antarمشاهده پروفایل

استادیار

• Metabolism
• Nutrition
• Obesity
• +۴ مورد دیگر

Dr. Alli Antar is an Assistant Professor of Nutrition at Baylor College of Medicine in Houston, Texas. Their research focuses on understanding the links between nutrient metabolism and health, with a particular emphasis on obesity, fatty liver disease, and cardiovascular disease. Dr. Antar holds memberships in several institutes, including the Inclusion and Excellence Council , Cardiovascular Research Institute , and Center for Research in Obesity and Nutrition . Education includes a PhD in Molecular Physiology and Biophysics from Vanderbilt University (Nashville, TN) and a Postdoctoral Fellowship in Pediatric Gastroenterology, Hepatology, and Nutrition at Baylor College of Medicine. Awards include the ENDO2010 Presidential Poster Competition Award and the AHA Postdoctoral Fellowship Award. Research interests span three core areas: adipocyte metabolism , hepatocyte metabolism , and immunometabolism . Dr. Antar's lab uses advanced techniques such as molecular biology, in vivo metabolic phenotyping, and transgenic mice to study disease mechanisms. Recent publications highlight breakthroughs in hepatic stellate cell regulation, vitamin B2's role in glucose metabolism, and novel insights into brown adipose tissue physiology. Grants: USDA/ARS Cooperative Agreement (2024–2029) American Heart Association Career Development Award (2018–2022) Labs/Teams: Primary lab focuses on metabolic syndrome and liver disease. Collaborates with the Dan L Duncan Comprehensive Cancer Center and Digestive Diseases Center .

Mahmoud Ali Mohammadمشاهده پروفایل

مدرس

• Nutritional Biochemistry
• Pediatric Metabolism
• Amino Acid Metabolism
• +۳ مورد دیگر

Mahmoud Ali Mohammad, Ph.D., is an Instructor in the Department of Pediatrics-Nutrition at Baylor College of Medicine in Houston, Texas. His research focuses on amino acid metabolism, particularly arginine and citrulline pathways, with applications in pediatric and clinical nutrition. He holds a Ph.D. in Nutrition from Cairo University (2008), alongside earlier degrees from the same institution. Key research interests include developmental changes in nutrient utilization, metabolic disorders in children undergoing surgery, and the interplay between diet, microbiome, and health. His work employs animal models (e.g., pigs, mice) and clinical trials to explore mechanisms of metabolic dysfunction and potential interventions. Dr. Mohammad has published extensively on topics such as arginine depletion in piglets, citrulline recycling in mice, and the effects of lipid emulsions on neonatal brain development. His studies frequently bridge basic science and clinical practice, addressing challenges in pediatric nutrition and metabolic care. While no awards or grants are explicitly listed, his research demonstrates a focus on translational medicine with applications in critical care, surgical outcomes, and nutritional support. He contributes to collaborative projects involving Baylor’s renowned medical and nutritional research teams.

Huaizhu Wuمشاهده پروفایل

استاد

• Obesity
• Inflammation
• Insulin Resistance
• +۵ مورد دیگر

Huaizhu Wu, M.D., is a Professor at Baylor College of Medicine, located in Houston, Texas. He holds a position within the Department of Medicine - Atherosclerosis and Lipid Metabolism under the School of Medicine. His research focuses on the interplay between inflammation, lipid metabolism, and metabolic disorders such as obesity, diabetes, and atherosclerosis. He completed his medical degree (MD) at Weifang Medical College in China, followed by a Master of Science at Peking Union Medical College. He also conducted postdoctoral research at Baylor College of Medicine. Research Interests Obesity-associated inflammation and insulin resistance Role of monocytes/macrophages in atherosclerosis and lipid disorders Translational research bridging basic science and clinical applications Influence of dietary lipids and pharmacological agents on cardiovascular health His work utilizes animal models, human specimens, and advanced molecular techniques to study how hyperlipidemia and obesity drive immune cell dysregulation in adipose tissue and blood vessels. Notable contributions include elucidating mechanisms of foam cell formation in atherosclerosis and the role of CD11c+ monocytes in disease progression. Grants & Funding NIH-funded projects on metabolic inflammation in aging and obesity American Heart Association grant investigating hypertriglyceridemia's link to atherosclerosis Labs & Collaborations Dr. Wu leads a team focusing on immunometabolism and lipid-related cardiovascular diseases, collaborating with institutions like the Texas Heart Institute and the Department of Molecular Physiology at Baylor College of Medicine.

Russell Scott Rayمشاهده پروفایل

دانشیار

• Neuroscience
• Respiratory Physiology
• Neurophysiology
• +۳ مورد دیگر

Russell Scott Ray, Ph.D., is an Associate Professor at Baylor College of Medicine, holding academic appointments in the Departments of Neuroscience, Molecular Physiology and Biophysics, Biochemistry and Molecular Biology, and the Program in Developmental Biology. He serves as a McNair Scholar and Faculty Senator. His research focuses on neural circuits underlying breathing and their roles in disorders such as Sudden Infant Death Syndrome (SIDS) and panic disorder. Education includes a Postdoctoral Fellowship at Harvard Medical School, a Ph.D. from the University of Utah (2008), and a B.A. from Southern Oregon University (1999). Additional training includes research fellowships at the Instituto Cajal (Spain) and Eberhard Karls Universität Tübingen (Germany). His lab investigates the molecular and genetic basis of neural circuits critical for breathing and survival. Key projects include screening for genetic contributors to SIDS, functional mapping of noradrenergic neurons, and studying SARS-CoV-2 effects on the nervous system. Research is supported by grants from the National Heart, Lung, and Blood Institute (NHLBI), NIH, and other organizations. Awards: March of Dimes Basil O'Connor Fellowship, Parker B. Francis Fellowship, American Physiological Society New Investigator Award. Grants: R01HL130249: Noradrenergic mechanisms in breathing (NHLBI, $1.9M) R01HL161142: SIDS genetic screening (NHLBI, $2.3M) R21OD025327: Mouse genetics for circuit mapping (NIH, $250K) Lab members include postdoctoral researchers (e.g., Savannah Lusk), graduate students (e.g., Dipak Patel), and alumni such as Jenny Sun and Megan Key. The lab develops genetic tools and mouse models for neural circuit analysis, including CRISPR-based systems and intersectional alleles for precise circuit mapping.

Hannah Meyerمشاهده پروفایل

استادیار

• Systems Immunology
• T Cell Development
• Thymus Physiology
• +۳ مورد دیگر

Hannah Meyer is Assistant Professor at Cold Spring Harbor Laboratory and Cancer Center member. Her research uses systems immunology approaches to study T cell education in the thymus, combining experimental techniques with computational models to understand selection mechanisms that prevent autoimmunity. Her work has revealed differences in human versus mouse innate-like T cell maturation and identified cystatin C as a biomarker for cancer immunotherapy failure. Meyer received the 2021 UK Biobank Early Career Researcher award for genetic studies of heart function.

Jeffrey L Noebelsمشاهده پروفایل

استاد

• Neurogenetics
• Epilepsy
• Neurological Disorders
• +۳ مورد دیگر

Jeffrey L Noebels, M.D., Ph.D., holds the Cullen Trust for Health Care Endowed Chair in Neurogenetics and serves as Professor in Neurology, Neuroscience, and Molecular & Human Genetics at Baylor College of Medicine. He directs the Blue Bird Circle Developmental Neurogenetics Laboratory and participates in graduate programs in Integrative Molecular and Biomedical Sciences and Translational Biology and Molecular Medicine. Education includes a BA from Reed College (1972), MD from Yale University (1981), PhD from Stanford University (1977), residency at Massachusetts General Hospital (Boston), and postdoctoral training at Harvard University (1983). Certifications include Neurology from the American Board of Psychiatry and Neurology. Research focuses on gene regulation of neuronal excitability and inherited neurological diseases, particularly epilepsy and Alzheimer's. His lab uses mouse models to study ion channel mutations, synaptic plasticity, and network synchronization defects. Key advances include discoveries of epilepsy-linked mouse mutants (e.g., stargazer) and identification of Zn transporters' neuroprotective roles. Recent work explores Alzheimer's hyperexcitability mechanisms and translational genomic studies of ion channel genes in epilepsy. Major projects include a NIH-funded Human Channelopathy Project analyzing ion channel variants and a Center studying neurocardiac risk prediction. His work bridges basic science and clinical translation, addressing disease mechanisms in epilepsy, sudden death syndromes, and cognitive impairments. Lab activities employ electrophysiology, 2-photon imaging, and genomic tools to dissect network dysfunction. Collaborations with the Baylor Human Genome Sequencing Center highlight commitment to large-scale genomic research in neurological disorders.