معرفی
Jeffrey L Noebels, M.D., Ph.D., holds the Cullen Trust for Health Care Endowed Chair in Neurogenetics and serves as Professor in Neurology, Neuroscience, and Molecular & Human Genetics at Baylor College of Medicine. He directs the Blue Bird Circle Developmental Neurogenetics Laboratory and participates in graduate programs in Integrative Molecular and Biomedical Sciences and Translational Biology and Molecular Medicine.
Education includes a BA from Reed College (1972), MD from Yale University (1981), PhD from Stanford University (1977), residency at Massachusetts General Hospital (Boston), and postdoctoral training at Harvard University (1983). Certifications include Neurology from the American Board of Psychiatry and Neurology.
Research focuses on gene regulation of neuronal excitability and inherited neurological diseases, particularly epilepsy and Alzheimer's. His lab uses mouse models to study ion channel mutations, synaptic plasticity, and network synchronization defects. Key advances include discoveries of epilepsy-linked mouse mutants (e.g., stargazer) and identification of Zn transporters' neuroprotective roles. Recent work explores Alzheimer's hyperexcitability mechanisms and translational genomic studies of ion channel genes in epilepsy.
Major projects include a NIH-funded Human Channelopathy Project analyzing ion channel variants and a Center studying neurocardiac risk prediction. His work bridges basic science and clinical translation, addressing disease mechanisms in epilepsy, sudden death syndromes, and cognitive impairments.
Lab activities employ electrophysiology, 2-photon imaging, and genomic tools to dissect network dysfunction. Collaborations with the Baylor Human Genome Sequencing Center highlight commitment to large-scale genomic research in neurological disorders.
