جستجوی استاد راهنمای دانشگاهی

John Davisمشاهده پروفایل

استاد

• Dementia
• Neurodegenerative Diseases
• Drug Discovery
• +۵ مورد دیگر

John Davis serves as Professor, Group Head/PI, and Unit Director of the Alzheimer’s Research UK Oxford Drug Discovery Institute (ODDI) at the University of Oxford, housed within the Centre for Medicines Discovery. As Chief Scientific Officer (CSO), he leads this institute within the Alzheimer’s Research UK Drug Discovery Alliance alongside Cambridge and UCL to accelerate therapeutics for neurodegenerative diseases. His research focuses on: Dementia and Neurodegenerative Disease Mechanisms Structural Biology-Driven Drug Discovery Target Identification for USP30, TREM2, and Lysosomal Pathways Integration of Biology, Chemistry, and Neuroscience Translational Target-to-Lead Optimization Recent publications emphasize structural characterization of deubiquitinases, lysosomal modulators via TFEB/TFE3, and neuroinflammation targets, demonstrating a cohesive strategy for Alzheimer's drug development through biochemical and phenotypic screening approaches. No information on student advising or research grants was provided in the source text. The ODDI under Professor Davis operates as a specialized hub within Oxford's Centre for Medicines Discovery, leveraging academic disease expertise with industrial drug discovery rigor to advance projects toward clinical translation for dementia therapeutics.

Utpal Palمشاهده پروفایل

استاد

• Lyme disease
• Leptospirosis
• Vector Biology
• +۷ مورد دیگر

Dr. Utpal Pal is a Professor in the Department of Veterinary Medicine at the University of Maryland, College Park , where he has served since 2006. He is also an Affiliate Professor in the Department of Entomology at the same institution. Dr. Pal directs the Veterinary Medical Sciences (VMSC) Graduate Program (2016-2019) and leads the Tick Immunity research initiative. Education: M.Sc. (1988), Ph.D. (1994) from University of Calcutta, Postdoctoral Training (2002) at Yale University Research Focus : Dr. Pal investigates molecular mechanisms of vector-borne diseases , particularly Lyme disease and Leptospirosis . His work explores genetic determinants of Borrelia burgdorferi and Leptospira interrogans , emphasizing host-vector-pathogen interactions , immunomodulation , and next-generation therapeutics . His lab employs genomics, proteomics, and structural biology to uncover pathogenesis pathways and vaccine targets. Dr. Pal's recent research trends include: Tick immune signaling (Dome1-JAK-STAT pathway) Genomic analysis of Ixodes scapularis Epigenetic regulation in vector biology Novel vaccine strategies (mRNA, protein targets) Proteolytic processing of virulence factors Tick gut barriers and microbiome-pathogen dynamics Funding Sources : His work has been supported by NIH-NIAID NIH-NIAMS American Heart Association Arthritis Foundation Department of Defense Cohen Foundation Global Lyme Alliance MAES Merck Lab Members : The Pal Lab includes 8 active graduate students specializing in Lyme disease pathogenesis, tick immunity, and microbial persistence , along with research scientists and faculty specialists.

• Molecular Biology
• Microbiology
• Biochemistry
• +۴ مورد دیگر

Stefan Irniger serves as a faculty member at a German-speaking academic institution, where he has supervised numerous doctoral candidates between 2004 and 2014. His academic position as a Privatdozent (PD) indicates he has completed the habilitation process, the highest academic qualification in the German system. Dr. Irniger's research spans multiple areas of molecular and cellular biology, with particular emphasis on: Microbial pathogenesis and host-pathogen interactions Fungal and yeast molecular genetics Protein regulation and post-translational modifications Enzyme structure and function Cellular metabolism and signaling pathways His doctoral students have published work examining diverse biological systems including Toxoplasma gondii, Saccharomyces cerevisiae, Aspergillus nidulans, and various plant-pathogen interactions. The publications demonstrate a consistent focus on molecular mechanisms underlying cellular processes, with particular attention to protein regulation, metabolic pathways, and host-microbe interactions. His students' work appears across multiple subdisciplines including parasitology, fungal genetics, enzymology, and membrane biology. Dr. Irniger has guided 18 doctoral students to completion, with dissertation topics spanning from 2004-2014. His students have investigated fundamental biological questions with implications for infectious disease, agricultural pathology, and basic cellular mechanisms. While specific awards are not documented in the available records, the breadth and quality of supervised research indicates significant scholarly contribution to his fields of expertise.

Tore B. Stageمشاهده پروفایل

استاد

• Pharmacogenetics
• Drug Interactions
• Pharmacokinetics
• +۵ مورد دیگر

Tore B. Stage is a Professor and Research Leader at the Institute for Health Services Research (Clinical Pharmacology, Pharmacy and Environmental Medicine) at the University of Southern Denmark. His research focuses on individual variability in drug response, particularly drug interactions and pharmacogenetics, utilizing both in vitro models and clinical trials. Primary research areas: Pharmacogenetics Chemotherapy-Induced Peripheral Neuropathy Pharmacokinetic Modeling Drug Transport Mechanisms Key publications include mechanistic studies of neurotoxicity in cancer patients and translational models bridging in vitro and clinical findings. His work spans immunosuppressants, anticoagulants, and chemotherapeutic agents. Major scientific awards: Lundbeckfondens Talentpris (2017) DFF-Research Talent (2015) ISSX Poster Award (2017) Presidential Trainee Award (2016) Jason Morrow Trainee Award (2016) He supervises PhD students, including Mortensen, C. (2020-2022), on projects exploring chemotherapy-induced neuropathy mechanisms.

Simon Boultonمشاهده پروفایل

استاد

• DNA Damage Response
• DNA Repair
• Genome Integrity & Repair
• +۷ مورد دیگر

Simon Boulton is a distinguished molecular biologist and cancer researcher serving as a Senior Group Leader at the Francis Crick Institute and holding an honorary Professorship at University College London. He also serves as Senior Vice President of Science Strategy at Artios Pharma Ltd, which he helped establish in 2016, where he additionally chairs the Scientific Advisory Board and serves on the Executive Board. His educational background includes: Molecular Biology studies at the University of Edinburgh PhD at the University of Cambridge with Professor Steve Jackson (Gurdon Institute) EMBO and HFSP funded postdoctoral fellowships at Harvard Medical School with Prof. Nick Dyson (MGH Cancer Centre) and Prof. Marc Vidal (Dana Farber Cancer Institute) Boulton's research focuses on understanding DNA damage response mechanisms, particularly DNA double-strand break repair in both mitotic and meiotic cells. His laboratory employs the complementary experimental strengths of C. elegans and mouse genetics, combined with cell biology and biochemistry approaches. Over his career, his lab has discovered novel DNA repair genes and provided crucial molecular insights into human diseases, especially cancer. His work bridges fundamental biological processes with potential therapeutic applications in oncology. Analysis of his recent publications reveals a consistent focus on genome integrity mechanisms, with particular emphasis on DNA repair pathways, telomere biology, replication stress responses, and the development of novel assays to study these processes. His research increasingly intersects with cancer therapeutics, particularly through his work with Artios Pharma on DNA Damage Response (DDR) target pipelines. His significant scientific contributions have been recognized with numerous prestigious awards: Member of EMBO Fellowship of the Academy of Medical Sciences Colworth Medal European Association for Cancer Research (EACR) Young Investigator Award Eppendorf/Nature Award for Young European Investigators Royal Society Wolfson Research Merit award EMBO Gold Medal Paul Marks Prize for Cancer Research Royal Society Francis Crick Prize lecture Mendel Lecture Boulton has secured substantial research funding throughout his career, including EMBO and HFSP postdoctoral fellowships, and currently leads a well-funded research group at the Crick Institute. His dual role in academia and industry through Artios Pharma demonstrates a successful translation of basic research into therapeutic development, with the company building an innovative DNA Damage Response (DDR) target pipeline aimed at transforming cancer therapy. His laboratory at the Francis Crick Institute maintains strong collaborative networks across multiple disciplines, utilizing advanced facilities including proteomics, genomics, bioinformatics, and microscopy resources. The lab's work spans from fundamental DNA repair mechanisms to potential clinical applications, with a particular focus on how failures in DNA repair contribute to cancer and other diseases.

Timo V. Ovaskaمشاهده پروفایل

استاد

• Organic Chemistry
• Organic Synthesis
• Natural Product Synthesis
• +۷ مورد دیگر

Timo V. Ovaska serves as the Hans & Ella McCollum '21 Vahlteich Professor of Chemistry at Connecticut College, where he has been a distinguished faculty member since 1990. His career combines exceptional research in organic chemistry with dedicated undergraduate teaching and mentorship. Professor Ovaska received his M.S. from the University of Turku and his Ph.D. from the University of Connecticut, establishing the foundation for his research in synthetic organic chemistry. His educational background positioned him to make significant contributions to the field of organic synthesis. His research program centers on developing innovative methodologies for constructing complex polycyclic ring systems, with particular expertise in seven-membered (cycloheptane) and eight-membered ring-containing natural products. Professor Ovaska's work has significant medicinal implications, as these compounds often exhibit anti-tumor, anti-HIV, antibacterial, and anti-inflammatory properties. His laboratory has pioneered the use of tandem oxyanionic cyclization/Claisen rearrangement sequences, particularly enhanced by microwave irradiation, to efficiently synthesize challenging ring systems found in biologically active natural products like the frondosins, phorbols, and guanacastepenes. Analysis of Professor Ovaska's publication record reveals a consistent focus on synthetic methodology development and natural product synthesis, with increasing sophistication in stereochemical control and ring system complexity over time. His work bridges fundamental organic chemistry with potential pharmaceutical applications, demonstrating the critical role of synthetic chemistry in addressing biological challenges. Professor Ovaska has received prestigious recognition including the Connecticut College 2010 Nancy Batson Nisbet Rash Faculty Research Award and the distinguished Hans & Ella McCollum '21 Vahlteich Professorship. His research has been supported by significant funding from the National Institutes of Health, ACS Petroleum Research Fund, Research Corporation, and the Camille and Henry Dreyfus Foundation. As an educator, Professor Ovaska has mentored dozens of undergraduate researchers who have co-authored publications and presented at national conferences. He teaches Organic Chemistry, Advanced Organic Chemistry, and a unique Medicinal Chemistry course developed with Pfizer researchers. His service on the Pre-Health Professions Advisory Committee demonstrates his commitment to guiding students toward medical and scientific careers. His expertise is also sought as a reviewer for leading chemistry journals including Organic Letters and the Journal of Organic Chemistry.

• Reproductive Medicine
• Endometriosis
• Ovarian Tissue Cryopreservation
• +۲ مورد دیگر

Enda McVeigh is an Associate Professor and Consultant Sub-Specialist in Reproductive Medicine and Surgery at the University of Oxford's Nuffield Department of Women's and Reproductive Health within the Medical Sciences Division. Appointed Associate Professor in 2014, he has held significant leadership roles including Director of the Sub-Specialist training program in Reproductive Medicine (1999-2012) and Medical Director of the Oxford Fertility Unit (1999-2012). His educational background includes undergraduate studies at Queen's University Belfast followed by MRCOG qualification. His clinical and academic journey led him to Imperial College London's Reproductive Medicine Team before joining Oxford in 1997 as a Sub-Specialist trainee. McVeigh's research spans Reproductive Medicine and Endometriosis , with current focus on Ovarian tissue cryopreservation for pre-pubertal and adolescent girls and supporting Endometriosis research led by Christian Becker. His work bridges clinical practice and academic research, evidenced by his role in developing the successful MSc course in Reproductive Medicine with Stephen Kennedy. Analysis of his publications reveals consistent focus on improving fertility treatment outcomes, embryo development assessment, and specialized care for cancer patients requiring fertility preservation. His research demonstrates strong clinical applicability with emphasis on practical improvements in IVF procedures and patient care. Professional activities include service on the HFEA Appeal Committee (2009-2012) and international work with USAID/WHO in Ukraine and Russia (1997-2000). He was a founding partner of the Reproductive Partnership, now the UK's largest IVF clinic network, and developed Oxford's Endometriosis surgical service into a national referral center through collaboration with Leuven University. McVeigh maintains active clinical and academic roles with ongoing research contributions, particularly in advancing care for young patients requiring fertility preservation and improving endometriosis treatment protocols.

• R-loop Biology
• Epigenetics
• DNA Methylation
• +۴ مورد دیگر

Frédéric Chédin is a Professor in the Department of Molecular and Cellular Biology at the University of California Davis, College of Biological Sciences. He has held continuous faculty positions at UC Davis since 2004, progressing from Assistant Professor (2004-2010) to Associate Professor (2010-2015), and currently serving as full Professor (2015-present). His research focuses on R-loop biology, DNA methylation, and epigenetic regulation. Chédin's laboratory investigates how RNA:DNA hybrids form, persist, and impact genome stability, with particular emphasis on their roles in transcription, chromatin organization, and disease mechanisms. His work has established foundational methodologies for R-loop detection and mapping, including critical assessments of common techniques like the S9.6 antibody. Chédin's publication record demonstrates consistent leadership in R-loop research, with numerous high-impact papers in journals like PNAS , Nature Communications , and Molecular Cell . His recent work explores protein-mediated R-loop stabilization, R-loop classification systems, and connections between R-loops and topological stress management. Director of NIH T32 Predoctoral Training Program in MCB (2020-present) Co-Director of NIH T32 Program (2019-2020) Chair of Integrative Genetics and Genomics (2015-2019) His laboratory trains numerous graduate students and postdoctoral researchers, with frequent collaborators including Stella Hartono and Lionel Sanz appearing as first authors on key publications. Chédin maintains active service roles in graduate education and program leadership at UC Davis.

Christina Baikمشاهده پروفایل

دانشیار

• Lung Cancer
• Thoracic Oncology
• Targeted Therapies
• +۳ مورد دیگر

Christina Baik, M.D., M.P.H. is an Associate Professor in the Division of Hematology and Oncology at the University of Washington School of Medicine and an Associate Professor in the Clinical Research Division at Fred Hutch Cancer Center. She serves as Clinical Research Director for Thoracic and Head and Neck Oncology at UW Medicine and practices at Fred Hutch Cancer Center locations in South Lake Union and UW Medical Center – Montlake. Dr. Baik received her medical degree from the University of Rochester School of Medicine, completed her residency in Internal Medicine at Brown University Medical School, and pursued fellowship training in Hematology/Oncology at Tufts Medical Center. She furthered her research training with a post-doctoral fellowship at Fred Hutchinson Cancer Research Center and earned a Master of Public Health from Harvard School of Public Health. Her research focuses on developing targeted therapeutics for oncogene-driven lung cancer, with particular interest in understanding mechanisms of primary and secondary resistance to immunotherapy. Dr. Baik leads multiple clinical trials evaluating the efficacy of small molecular inhibitors in lung cancer treatment. Her publication record shows consistent research output spanning from 2010 to 2025, with recent work emphasizing novel therapeutic approaches for EGFR-mutant and other molecularly defined lung cancers. Dr. Baik's clinical expertise centers on thoracic oncology, particularly lung cancer treatment. She treats patients with thoracic and head and neck malignancies at the UW/Fred Hutchinson Cancer Center and is actively involved in educating medical students, residents, and fellows.

Yazan Alwarawrahمشاهده پروفایل

استادیار

• Immunometabolism
• T cell biology
• Obesity-related immune dysfunction
• +۴ مورد دیگر

Dr. Yazan Alwarawrah is an Assistant Professor of Pediatrics at the University of North Carolina at Chapel Hill School of Medicine, specializing in Pediatric Endocrinology. His research focuses on the intersection of immunology and metabolism, with particular emphasis on how obesity affects immune function and the development of metabolic interventions for immune-related pathologies. Undergraduate: Al Al-Bayt University, Mafraq, Jordan Master of Science: Yarmouk University, Irbid, Jordan Doctor of Philosophy: Pharmacology, Duke University Dr. Alwarawrah's primary research interests center on immunometabolism, particularly how metabolic pathways regulate immune cell function in obesity and disease states. His work investigates T cell metabolism in the context of obesity-associated immune dysfunction, with specific focus on protective immunity against influenza. He also studies the role of Immunity Related GTPase I (Irgm1) in regulating T cell metabolism and function, and explores metabolic engineering approaches to enhance chimeric antigen receptor (CAR) T cell persistence in tumor microenvironments. His diverse scientific background spans molecular biology, bioinformatics, pharmacology, and immunology. Analysis of Dr. Alwarawrah's publication record reveals a strong focus on the intersection of metabolism and immunity, particularly in obesity contexts. His work spans fundamental mechanisms of immune cell metabolism to translational applications in infectious disease, cancer, and autoimmune conditions. Key themes include T cell metabolic dysfunction in obesity, macrophage metabolism, and pharmacological targeting of metabolic pathways for therapeutic benefit. His research employs diverse approaches including diet-induced obesity mouse models, metabolic and flow cytometric analyses, and pharmacological interventions. Dr. Alwarawrah's research program bridges basic science and clinical applications, with implications for treating obesity-associated pathologies, cancer, and autoimmune diseases through metabolic interventions. His work on T cell metabolism in obesity has particular relevance for understanding impaired immune responses in metabolic disease states. While specific grant information isn't detailed in the provided materials, his research trajectory suggests involvement in NIH-funded projects related to immunometabolism and obesity.

Adele McCormickمشاهده پروفایل

دانشیار

• Virology
• Antiviral Drug Resistance
• Human Endogenous Retroviruses
• +۲ مورد دیگر

Dr. Adele McCormick is Reader in Molecular Virology at the University of Westminster's School of Life Sciences, where she leads the Genomics and Infectious Diseases research group. She coordinates the MSc Biomedical Science program and teaches molecular biology and clinical microbiology. Education background: PhD in Sustainable Energy Systems, University of Sheffield MSc in Clinical Pathology, University of Sheffield BSc in Biochemistry and Microbiology, University of Sheffield Her research focuses on viral pathogenesis, antiviral resistance mechanisms in HIV/HCV, and the role of endogenous retroviruses in neurological disorders. She established the university's genomics facility for BSL-2 pathogen sequencing and collaborates internationally on antiviral development projects. Recent publications emphasize molecular diagnostics, SARS-CoV-2 therapeutics, and retroviral involvement in ALS. Her work shows increasing focus on nanoparticulate antivirals and long-read sequencing applications since 2020. Dr. McCormick has secured substantial research funding including an ALS Association grant ($325,000) and directs the Westminster virology research group. She is a Fellow of the Royal Society of Biology and serves on editorial boards for virology journals.

• Gene Regulation
• Chromatin Structure
• Molecular Biology
• +۱۲ مورد دیگر

Dr. Euan W. Baxter is a Research Fellow at the School of Medicine, University of Leeds, Faculty of Medicine and Health, affiliated with the Institute for Cancer and Pathology and the Discovery and Translational Science research group. His research centers on molecular mechanisms in gene regulation, chromatin dynamics, and protein signaling, particularly in cancer and immune pathways. His primary research interests include: Gene regulation and chromatin structure Protein-protein interactions and bioluminescent fusion systems Molecular cloning and recombinant protein expression Cellular assay development using flow cytometry and Fc gamma receptor signaling Apoptosis and oncogene addiction in cancer cell lines Although no recent publications are listed, his technical work suggests strong contributions in immunology, cancer biology, and molecular engineering, particularly in developing sensitive luciferase-based assays to monitor intracellular signaling events in real time. Dr. Baxter has no listed scientific awards or honors in the provided text. He has not advised any named students in the available information, and there is no mention of grant funding. However, his long-standing post-doctoral and research fellow roles across prestigious institutions indicate sustained research engagement and technical leadership. He is actively involved in the Discovery and Translational Science research group at Leeds, where he continues to explore the biology of Fc gamma receptors and their signaling mechanisms using advanced molecular and cellular techniques.

David Minhمشاهده پروفایل

دانشیار

• Computational Chemical Biology
• Protein Dynamics
• Molecular Interactions
• +۳ مورد دیگر

David Minh is an Associate Professor of Chemistry and the Robert E. Frey, Jr. Endowed Chair in Chemistry at Illinois Institute of Technology (IIT), affiliated with the Lewis College of Science and Letters. He serves as Associate Director of the Center for Interdisciplinary Scientific Computation (CISC). His research focuses on computational chemical biology, developing methods to predict protein dynamics and molecular interactions for structure-based drug design. Education: Ph.D. in Chemistry, University of California, San Diego M.S. in Chemistry, University of California, San Diego B.A. in Chemistry, University of California, Berkeley Research Interests: Dr. Minh's group specializes in computational methods to study small molecule-biological interactions, including: Structural mechanisms of G protein-coupled receptors (GPCRs) and signaling proteins Advanced binding free energy calculations incorporating entropy Enhanced sampling in molecular simulations Bayesian statistical integration of experimental data Modeling bacterial metabolic enzymes and inhibitor development Articles Trends: Recent work emphasizes antiviral drug discovery (e.g., SARS-CoV-2 protease inhibitors), Bayesian analysis of binding data, and computational tools like AlGDock for free energy predictions. Collaborations with biologists (e.g., Oscar Juárez) drive antibiotic discovery targeting pathogenic bacteria. Advising & Grants: Leads interdisciplinary projects funded by NIH and industry partnerships. Mentors students in computational modeling and experimental validation. Active in open science initiatives like the D3R Grand Challenge in drug design. Labs & Teams: Directs the Minh Computational Chemistry Lab at IIT, focusing on molecular simulations, machine learning, and interdisciplinary collaborations to address biomedical challenges.

Giulia De Lorenzoمشاهده پروفایل

استاد

• Plant immunity
• Plant-pathogen interactions
• Molecular recognition
• +۵ مورد دیگر

Giulia De Lorenzo is a Full Professor of Plant Physiology at Sapienza University of Rome since 2000, with prior roles as Associate Professor at Sapienza University of Rome (1994-1999) and University of Bari (1991-1994). Her research focuses on plant immunity, molecular recognition, and cell wall dynamics, particularly in plant-pathogen interactions involving damage-associated molecular patterns (DAMPs) and their role in signal transduction. Education: Laurea in Biology (1980, Sapienza University of Rome, cum laude), PhD in Evolutionary Biology (1987, Sapienza University of Rome) Her work explores the structural and functional basis of plant defense mechanisms, including the inhibition of cell wall-degrading enzymes and engineering plant resistance through chimeric receptors. Articles highlight her contributions to understanding DAMPs, PGIP proteins, and their applications in crop protection and bioconversion. Notable scientific awards include the 2011 Sapienza University of Rome Award for Excellence in Research , 1997 Giovanni Armenise-Harvard Foundation Award , and the 1983 Fondazione V.V. Landi Award from the Accademia dei Lincei. She has served on editorial boards and organized international conferences in plant science.

• Protease Inhibition
• PROTACs
• Activity-Based Probes
• +۶ مورد دیگر

Prof. Michael Gütschow is a Professor at the Pharmaceutical Institute of the University of Bonn. His research focuses on designing tailored inhibitors for proteases involved in cancer, viral infections (e.g., SARS-CoV-2), and developing proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. He leads projects in drug discovery, including antiviral agents and epigenetic therapies. His work spans protease inhibition mechanisms, activity-based probes for enzyme analysis, and novel drug modalities like PROTACs for cyclin-dependent kinases and cereblon. Notable collaborations include studies on CDK6 degraders for multiple myeloma and SARS-CoV-2 main protease inhibitors. Recent publications highlight advancements in histone deacetylase degraders, NLRP3 inflammasome modulation, and USP7-targeting PROTACs. His research bridges biochemistry, medicinal chemistry, and translational medicine, contributing to innovative therapeutic strategies.