معرفی
David Minh is an Associate Professor of Chemistry and the Robert E. Frey, Jr. Endowed Chair in Chemistry at Illinois Institute of Technology (IIT), affiliated with the Lewis College of Science and Letters. He serves as Associate Director of the Center for Interdisciplinary Scientific Computation (CISC). His research focuses on computational chemical biology, developing methods to predict protein dynamics and molecular interactions for structure-based drug design.
Education:
- Ph.D. in Chemistry, University of California, San Diego
- M.S. in Chemistry, University of California, San Diego
- B.A. in Chemistry, University of California, Berkeley
Research Interests:
Dr. Minh's group specializes in computational methods to study small molecule-biological interactions, including:
- Structural mechanisms of G protein-coupled receptors (GPCRs) and signaling proteins
- Advanced binding free energy calculations incorporating entropy
- Enhanced sampling in molecular simulations
- Bayesian statistical integration of experimental data
- Modeling bacterial metabolic enzymes and inhibitor development
Articles Trends:
Recent work emphasizes antiviral drug discovery (e.g., SARS-CoV-2 protease inhibitors), Bayesian analysis of binding data, and computational tools like AlGDock for free energy predictions. Collaborations with biologists (e.g., Oscar Juárez) drive antibiotic discovery targeting pathogenic bacteria.
Advising & Grants:
Leads interdisciplinary projects funded by NIH and industry partnerships. Mentors students in computational modeling and experimental validation. Active in open science initiatives like the D3R Grand Challenge in drug design.
Labs & Teams:
Directs the Minh Computational Chemistry Lab at IIT, focusing on molecular simulations, machine learning, and interdisciplinary collaborations to address biomedical challenges.
