Yazan Alwarawrah

Dr. Yazan Alwarawrah is an Assistant Professor of Pediatrics at the University of North Carolina at Chapel Hill School of Medicine, specializing in Pediatric Endocrinology. His research focuses on the intersection of immunology and metabolism, with particular emphasis on how obesity affects immune function and the development of metabolic interventions for immune-related pathologies.

• Undergraduate: Al Al-Bayt University, Mafraq, Jordan
• Master of Science: Yarmouk University, Irbid, Jordan
• Doctor of Philosophy: Pharmacology, Duke University

Dr. Alwarawrah's primary research interests center on immunometabolism, particularly how metabolic pathways regulate immune cell function in obesity and disease states. His work investigates T cell metabolism in the context of obesity-associated immune dysfunction, with specific focus on protective immunity against influenza. He also studies the role of Immunity Related GTPase I (Irgm1) in regulating T cell metabolism and function, and explores metabolic engineering approaches to enhance chimeric antigen receptor (CAR) T cell persistence in tumor microenvironments. His diverse scientific background spans molecular biology, bioinformatics, pharmacology, and immunology.

Analysis of Dr. Alwarawrah's publication record reveals a strong focus on the intersection of metabolism and immunity, particularly in obesity contexts. His work spans fundamental mechanisms of immune cell metabolism to translational applications in infectious disease, cancer, and autoimmune conditions. Key themes include T cell metabolic dysfunction in obesity, macrophage metabolism, and pharmacological targeting of metabolic pathways for therapeutic benefit. His research employs diverse approaches including diet-induced obesity mouse models, metabolic and flow cytometric analyses, and pharmacological interventions.

Dr. Alwarawrah's research program bridges basic science and clinical applications, with implications for treating obesity-associated pathologies, cancer, and autoimmune diseases through metabolic interventions. His work on T cell metabolism in obesity has particular relevance for understanding impaired immune responses in metabolic disease states. While specific grant information isn't detailed in the provided materials, his research trajectory suggests involvement in NIH-funded projects related to immunometabolism and obesity.