جستجوی استاد راهنمای دانشگاهی

Hongmin Li is a Professor in the Department of Pharmacology and Toxicology at the University of Arizona, specializing in antiviral and antifungal drug discovery. His research focuses on enzyme inhibition mechanisms, particularly targeting viral proteases and fungal inteins. He has developed high-throughput screening assays for identifying novel inhibitors of pathogens like SARS-CoV-2 and flaviviruses. His work bridges structural biology, medicinal chemistry, and pharmacology to combat infections caused by viruses and fungi. Research interests include: (1) Structure-based design of antiviral agents targeting viral methyltransferases and proteases, (2) Inhibition of fungal inteins for antifungal therapy, (3) Development of broad-spectrum inhibitors for emerging pathogens, (4) Mechanistic studies of host-pathogen interactions, and (5) Optimization of drug delivery systems for improved efficacy. Notable trends in his publications show sustained focus on SARS-CoV-2 protease inhibition (2023-2025), flavivirus NS2B-NS3 protease targeting (2022-2023), and intein-based antifungal strategies (2022). His articles consistently emphasize translational research with in vitro/in vivo validation of compounds. Collaborative work includes structural biology studies (X-ray crystallography), biochemical assays, and pharmacokinetic analysis. No scientific awards are explicitly mentioned in the provided texts. His research involves multidisciplinary teams with expertise in virology, medicinal chemistry, and computational biology. Current efforts prioritize developing clinically viable antiviral agents and understanding resistance mechanisms in pathogens.

• Antiviral Drug Discovery
• Enzyme Inhibition
• Fungal Pathogenesis
• +۳ مورد دیگر

Roman Manetsch is a Professor of Chemistry and Chemical Biology at Northeastern University, with a joint appointment in the Bouvé College of Health Sciences. His research focuses on medicinal chemistry, particularly developing novel therapies for neglected parasitic diseases like malaria and leishmaniasis, as well as antibacterial agents targeting drug-resistant pathogens. He leads the Manetsch Lab, which integrates mass spectrometry-based approaches with synthetic chemistry to optimize drug candidates. Expertise includes kinetic target-guided synthesis, protein crosslinking strategies for neurodegenerative diseases, and the discovery of compounds targeting Plasmodium species. Notable contributions include advancements in antimalarial drug design, development of streptothricin F as a novel antibiotic, and synthetic methodologies like sulfo-click and seleno-click amidation. Recipient of the 2023 TIER1 Seed Grant for innovative drug discovery research Leading multidisciplinary projects with the Barnett Institute of Chemical and Biological Analysis Collaborations in both biomedical research and pharmaceutical sciences Research trends emphasize translational applications of synthetic chemistry, with recent work exploring multifragment screening for protein interaction modulators and biocompatible reaction systems for targeted drug delivery. His lab’s publications consistently address critical gaps in treating neglected tropical diseases and antibiotic-resistant infections.

• Medicinal Chemistry
• Antimicrobial Agents
• Antiparasitic Drug Development
• +۳ مورد دیگر

Shrikant Mane is a Professor of Genetics at Yale University, affiliated with the Yale School of Medicine. He holds dual directorships at the Yale Center for Genome Analysis (YCGA) Shared Resource and the Keck Biotechnology Resource Laboratory. His research focuses on genomic and proteomic technologies, including microarray and high-throughput DNA sequencing. Mane has over 25 years of academic and industry experience, with significant NIH funding and 125+ publications. He leads the Yale Center for Mendelian Genomics and pursues neuroscience research alongside his lab leadership roles. Education: PhD in Cancer Biology from the University of Bombay (1985), Postdoctoral training at Johns Hopkins University School of Medicine. His labs have provided genomic services to over 350 principal investigators globally. Collaborations include work with renowned researchers like Richard Lifton and Murat Günel. Research Interests: Genomic technologies, genetic basis of kidney diseases, neurodevelopmental disorders, and translational genomics. His work bridges clinical and basic science, with emphasis on applying genomic analyses to uncover disease mechanisms. Grants & Funding: Secured an $11.2M NHGRI grant for the Yale Center for Mendelian Genomics. Active in multi-institutional projects addressing congenital anomalies, kidney disorders, and neurovascular malformations. Labs & Teams: Directs YCGA and Keck Biotech labs, which provide cutting-edge genomic services including library preparation, sequencing, and bioinformatics. These facilities support over 72 national and 16 international institutions.

• Genetics
• Genomics
• Proteomics
• +۳ مورد دیگر

Satu Mustjoki is a Professor of Translational Hematology at the University of Helsinki (UH), Finland, and holds leadership roles such as Director of the Translational Immunology Research Program (2019–2025) and former Head of the Department at the Helsinki University Hospital (HUS) Comprehensive Cancer Center (2018). She is affiliated with the Faculty of Medicine, UH, and specializes in hematology and immunology. Her research spans somatic mutations in non-malignant diseases, NK cell biology, and personalized medicine. She has led over 20 international grants totaling millions in funding, including ERC Consolidator (€2.047M) and NIH/Academy of Finland collaborations. Education: MD (1997, UH), PhD (2001, UH with distinction), Adjunct Professor (Docent) in Experimental Hematology (2011). Awards include the 2020 City of Helsinki Science Award and ERC Proof-of-Concept grant (2020). Her work bridges clinical and translational research, with focus on immunological biomarkers and cancer immunotherapy. Research emphasizes somatic mutations in autoimmune diseases (e.g., rheumatoid arthritis), T and NK cell dysfunction in blood cancers, and precision medicine strategies. She has supervised 18 completed PhDs and 9 ongoing postdocs, with over 9,900 citations and an H-index of 49. Leadership roles include Scientific Director of the iCAN Digital Precision Cancer Medicine Flagship (2022–2026) and membership in the European Hematology Association’s program committee. Funding highlights include the Academy of Finland Terva Consortium (€830K), EraPerMed EU project (€566K as PI), and industry grants from Pfizer and Novartis. She leads global clinical trials and biomarker programs, contributing to drug discovery and patient stratification strategies in hematologic malignancies.

• Natural killer cells
• Translational hematology
• Somatic mutations
• +۷ مورد دیگر

Van Thai is a Postdoctoral Research Associate at the University of Western Australia's Marshall Centre for Infectious Diseases, affiliated with the School of Biomedical Sciences' Microbiology and Immunology department. He holds a PhD in Medicine-Biological Sciences (UWA, 2024) and has industry experience at Rohto-Mentholatum (Vietnam). His research focuses on developing pharmaceutical solutions for bacterial infections, particularly multi-drug resistant Neisseria gonorrhoeae. He has contributed to projects like the 'Highly multiplexed real-time PCR capacity for biomedical research' grant (2024). Education Doctor of Philosophy (Medicine-Biological Sciences), University of Western Australia (2024) Master of Science (Biotechnology), International University, Vietnam National University (2017) Bachelor of Engineering (Biotechnology), International University, Vietnam National University (2013) Research Interests Van's work addresses antimicrobial resistance and infectious disease prevention. He investigates novel therapeutics targeting bacterial pathogens like Neisseria gonorrhoeae and Staphylococcus aureus. Key areas include drug discovery, vaccine development, and understanding resistance mechanisms through genomic and proteomic analysis. Grants & Awards Recipient of multiple scholarships/funds: University Postgraduate Awards (2020), Shellam Fund (2023), New Investigator Award (2024) Contributor to the UWA PCR capacity grant Labs/Teams Active in the Marshall Centre for Infectious Diseases, collaborating with institutions on antimicrobial resistance research.

• Antimicrobial Resistance
• Infectious Disease Prevention
• Microbiology
• +۳ مورد دیگر

Kim McCall is a Professor of Biology at Boston University, where she leads research on Drosophila developmental biology, cell death mechanisms, and oogenesis. Her laboratory investigates molecular mechanisms of programmed cell death and cell clearance using Drosophila melanogaster as a model organism. Her research focuses on: Germline cell death during oogenesis Non-apoptotic cell death pathways Corpse clearance by epithelial follicle cells Neurodegenerative mechanisms linked to phagocytic defects Evolutionary conservation of cell death pathways Recent publications demonstrate McCall's focus on phagocytosis mechanisms, neurodegenerative pathways, and non-apoptotic cell death, consistently utilizing Drosophila models to uncover fundamental biological processes with human disease implications. McCall teaches advanced courses in genetics and carcinogenesis, including BI 572 Advanced Genetics and BI 576 Carcinogenesis.

• Developmental Biology
• Cell Death Mechanisms
• Oogenesis
• +۳ مورد دیگر

Melody Morris is an Assistant Professor in the Department of Polymer Science and Engineering at the University of Massachusetts Amherst . Her research focuses on developing sustainable macromolecular materials through automated and high-throughput methodologies combined with advanced physical characterization. She leads the Morris Research Group, which bridges polymer science, protein engineering, and automation to address challenges in material sustainability and functionality. Education: B.S. Chemical Engineering, California Institute of Technology (2013) Ph.D. Chemical Engineering, University of Delaware (2019) Research Interests: Her work emphasizes proteins as polymers, sustainable polymers, high-throughput tool development, polymer biodegradation, and self-assembled systems. She aims to create next-generation biomaterials, nanoreactors, and membranes by integrating protein and synthetic polymer systems. Recent projects include ion-conducting bio-based polymers, toxin-binding hydrogels, and canonicalizing BigSMILES notation for polymer informatics. Research Trends from Publications: A recurring theme in her articles is the optimization of materials via high-throughput screening, with a focus on functional polymers for energy storage (e.g., lithium-ion batteries), environmental applications, and smart responsive materials. Her work often combines computational modeling with experimental validation to predict and enhance material properties. Labs & Affiliations: Morris's lab is part of the Sylvio O. Conte National Center for Polymer Research , fostering interdisciplinary collaboration in polymer science. The group actively seeks students passionate about macromolecular engineering, automation, and sustainable materials design.

• Sustainable Polymers
• Proteins as Polymers
• High-Throughput Materials Development
• +۵ مورد دیگر

Associate Professor David Anthony Jacques leads the Structural Virology Group at the EMBL Australia Node for Single Molecule Science, UNSW Sydney. He holds a PhD from the University of Sydney and completed postdoctoral research at the MRC Laboratory of Molecular Biology, Cambridge. His work focuses on structural biology of HIV and other viruses, employing techniques like X-ray crystallography, cryo-EM, and single-molecule fluorescence. Key research areas include HIV capsid structure-function relationships, host-pathogen interactions, and viral immune evasion mechanisms. Education: PhD in Biochemistry, University of Sydney (supervised by Professors Jill Trewhella and Mitchell Guss) BSc (Advanced) (Hons) in Biochemistry and Chemistry Research Interests: Structural basis of viral infection, HIV capsid dynamics, nuclear transport mechanisms, and development of antiviral strategies. His studies reveal how HIV exploits host machinery for replication and how viral proteins interact with cellular cofactors like nucleoporins and innate immune sensors. Grants & Awards: NHMRC Early Career Fellowship (2012-2017) Wellcome Trust Collaborator Award (2019-2024) ARC Discovery Project (DP180101384) Advising & Labs: Supervises Honours, Masters, and PhD students in virology and structural biology. Leads the Structural Virology Group with expertise in advanced microscopy and biophysical techniques. Collaborates on the X-ray Facility for Protein Crystallography funded under ARC LE190100165.

• Structural Biology
• Virology
• Host-Pathogen Interactions
• +۳ مورد دیگر

Siyuan (Steven) Wang, an Associate Professor at Yale University's School of Medicine, holds dual appointments in Genetics and Cell Biology. His research focuses on 3D genomics, spatial multi-omics, and chromatin architecture. He pioneered the 'chromatin tracing' method and developed the MINA platform for nucleome imaging. Key contributions include studies on X chromosome folding, cancer genome evolution, and aging mechanisms. Education: B.Sc. in Physics from Peking University (2007), Ph.D. in Molecular Biology from Princeton University (2011), postdoctoral training at Harvard University (2011–2017). His lab integrates imaging, genetics, and computational tools to dissect genome organization in health and disease. Research highlights include resolving single-cell 3D genome maps in cancer, discovering regulators of chromatin architecture via Perturb-tracing, and mapping senescent cell dynamics in aging tissues. Awards include the NIH Director’s New Innovator Award (2019–2024) and ASCB Innovation in Research Award (2024). Labs/Teams: Directs the Siyuan Wang Lab at Yale, collaborating with institutions like the NIH SenNet Consortium. Ongoing work explores spatial transcriptomics and functional regulators of chromatin in disease contexts.

• 3D Genomics
• Spatial Multi-Omics
• Chromatin Architecture
• +۴ مورد دیگر

Dr. Leonidas Bleris is a Professor of Bioengineering at the University of Texas at Dallas (UT Dallas), affiliated with the Erik Jonsson School of Engineering and Computer Science. His research focuses on synthetic biology, gene circuit design, and systems biology, with applications in gene therapy, cancer treatment, and biosecurity. He holds a PhD in Electrical Engineering from Lehigh University and completed a postdoc in systems biology at Harvard University. Key research interests include engineering genetic circuits for noise control, developing RNA-based communication systems, and applying CRISPR technologies for genome editing. Notable achievements include the NSF CAREER Award for early-stage investigators. His work bridges electrical engineering principles with biological systems, emphasizing quantitative approaches to understand and manipulate cellular networks. Dr. Bleris has collaborated on projects such as engineering robust gene networks, developing plasmonic detection systems for SARS-CoV-2, and exploring biosecurity primitives using genetic unclonable functions. He has supervised interdisciplinary studies on cellular noise, transcriptional logic, and biomarker identification in metastatic cancers. Awards: NSF CAREER Award (2013) Projects: Includes collaborations on gene network engineering, biosecurity tools, and CRISPR-based therapies Labs: Leads a lab focused on synthetic biology and molecular engineering at UT Dallas Publications span synthetic gene circuits, biomarker discovery, and computational models of biological systems, reflecting his expertise in merging engineering and life sciences.

• Synthetic Biology
• Gene Therapy
• Biomedical Engineering
• +۳ مورد دیگر

Matti Mäntysalo is a Professor in the Department of Electrical Engineering at the Faculty of Information Technology and Communication Sciences, Tampere University. His research focuses on advanced materials for energy storage systems, printed electronics, and biomedical applications. He leads projects on supercapacitors, flexible/stretchable electronics, and biosensors, with a strong emphasis on sustainability and biodegradability. Mäntysalo has authored over 130 publications and contributed to initiatives like the ECOtronics research project (2019–2022). His work integrates material science, nanotechnology, and engineering to develop next-generation energy storage solutions and wearable medical devices. Key contributions include dopamine-functionalized supercapacitors, piezoelectric PLLA sensors for cardiovascular monitoring, and 3D-printed biodegradable electrodes. He also explores scalable manufacturing techniques such as roll-to-roll printing for monolithic supercapacitors and membrane-based energy systems. Mäntysalo serves as an editorial board member for special issues on flexible sensors and MEMS technologies. His research bridges fundamental science and practical applications, addressing challenges in IoT, smart packaging, and sustainable electronics. Recent efforts include self-powered e-tattoo sensors and zero-discharge microbial electrolysis cells.

• Energy Storage Systems
• Printed Electronics
• Biosensors
• +۷ مورد دیگر

Maarten van Lohuizen is a Professor of Biology and Epigenetic Regulation of Stem Cells at the University of Amsterdam (since 2007, part-time) and holds a part-time Professor position at Amsterdam University Medical School. He serves as Head of the Division of Molecular Genetics at The Netherlands Cancer Institute (NKI) since 2002 and has been an Associate Professor/staff member there since 2000. His career spans significant contributions to epigenetics and cancer biology. Education: Cum Laude Masters (1986) and PhD (1992) in Biology from the University of Amsterdam Postdoctoral training: UCSF (1993-1995) and NKI (1992-1993) His research focuses on epigenetic gene silencing mechanisms via Polycomb-group protein complexes, which regulate development, differentiation, stem cell identity, and cancer formation. Current work employs human cancer organoids and mouse models to test epigenetic therapies and screen for Polycomb targets using in vivo shRNAi. Key research contributions include developing genome-wide high-throughput genetic screens in cell-based assays and cancer-prone mice to identify oncogenic pathways, as well as a novel transposon-based reporter system for chromatin effects on gene regulation. His work bridges fundamental epigenetic mechanisms with translational cancer research. 1999 PIONEER grant from NWO EMBO member since 2004 Member of Centre for Biomedical Genetics Multiple awards for academic excellence (cum laude degrees)

• Genetics
• Epigenetics
• Cancer biology
• +۵ مورد دیگر

Sergio Catz, PhD is a Professor in the Department of Molecular and Cellular Biology at Scripps Research. His research focuses on intracellular vesicular transport mechanisms and their roles in immunity, inflammation, and disease. He leads a laboratory utilizing super-resolution microscopy and systems biology approaches to study Rab GTPases and vesicular trafficking in innate immune cells. Education: PhD in Biological Sciences, University of Buenos Aires (1997) BSc in Biochemistry, University of Buenos Aires (1991) Research Interests: His work investigates molecular mechanisms of autophagy, exocytosis, and phagocytosis, with applications to coronary artery disease, lysosomal storage disorders, and autoinflammatory syndromes. The lab develops small-molecule inhibitors/activators of vesicular trafficking and employs high-throughput screening assays. Awards & Leadership: Chair-elect, Neutrophil Biennial International Symposium (2026) NIH Study Section Member (CSF1, MBPP) Editorial Board, Journal of Leukocyte Biology Recipient: Prize Boeringher Ingelheim (1995) Lab & Collaborations: The lab is internationally recognized for studying vesicular trafficking in innate immunity. Current projects include pre-clinical trials for lysosomal disorders and viral encephalitis using novel compounds.

• Intracellular Vesicular Transport
• Immunology
• Molecular Biology
• +۷ مورد دیگر

Dr. Lukas Gerstweiler is a Lecturer in the School of Chemical Engineering at the University of Adelaide, within the Faculty of Sciences, Engineering and Technology. His research focuses on advancing biomanufacturing processes, particularly continuous bioprocessing, downstream purification techniques, and virus-like particle (VLP) technology. He explores novel chromatography methods using porous co-polymers and mechanistic modeling to optimize biomolecule separation. His work aims to enhance efficiency in producing biotherapeutics, recombinant proteins, and vaccines. Dr. Gerstweiler’s research group emphasizes interdisciplinary approaches combining engineering, biology, and computational sciences. Key areas include VLP-based vaccine platforms for emerging pathogens and process intensification strategies for cost-effective biomanufacturing. He actively supervises research students in Masters and PhD programs, fostering innovation in sustainable protein production and healthcare solutions. His publications highlight contributions to VLP stability analysis, chromatography optimization, and continuous manufacturing systems. Collaborations are sought to address global health challenges through transformative biomanufacturing technologies.

• Biomanufacturing
• Continuous Bioprocessing
• Downstream Processing
• +۴ مورد دیگر

Jiang Zhe is a Professor in the Mechanical Engineering/Biomedical Engineering department at the University of Akron . With a career spanning over two decades, Dr. Zhe has made significant contributions to micro/nano sensor technology, biosensors, and machine health monitoring. He joined the University in 2003 after industry experience at Fitel Technologies and Advanced Micro Sensors, and was recognized as a Fellow of the American Society of Mechanical Engineers. Ph.D., Columbia University (2002) M. Phil., Columbia University (2000) B.S., Northwestern Polytechnic University (1993) Dr. Zhe’s research focuses on Micro and Nano Sensors , Lab-on-a-Chip , and Microfluidic Devices . His work integrates Artificial Neural Networks and Biosensors for applications in Machine Health Monitoring and Biomolecular Detection . Recent publications highlight advancements in Viscoelastic Fluids , Surface Charge Analysis , and Deep Learning for Sensor Arrays . Dr. Zhe has secured 11 funded NSF grants and received prestigious awards including the ASME Lewis F. Moody Award and the College of Engineering Outstanding Researcher Award . He leads a research group at the University of Akron’s MEMS Laboratory, where he develops cutting-edge technologies for particle manipulation, fluid analysis, and biomedical diagnostics. His laboratory specializes in Microfluidic Resistive Pulse Sensors , Inductive Sensors , and Wearable Devices , with applications in automotive systems, healthcare diagnostics, and environmental monitoring. Dr. Zhe’s interdisciplinary approach bridges mechanical engineering, biomedical science, and machine learning to solve complex challenges in sensor design and fluid dynamics.

• Micro and Nano Sensors
• Biosensors and Bioinstrumentation
• Lab on a Chip
• +۳ مورد دیگر