معرفی
Roman Manetsch is a Professor of Chemistry and Chemical Biology at Northeastern University, with a joint appointment in the Bouvé College of Health Sciences. His research focuses on medicinal chemistry, particularly developing novel therapies for neglected parasitic diseases like malaria and leishmaniasis, as well as antibacterial agents targeting drug-resistant pathogens. He leads the Manetsch Lab, which integrates mass spectrometry-based approaches with synthetic chemistry to optimize drug candidates.
Expertise includes kinetic target-guided synthesis, protein crosslinking strategies for neurodegenerative diseases, and the discovery of compounds targeting Plasmodium species. Notable contributions include advancements in antimalarial drug design, development of streptothricin F as a novel antibiotic, and synthetic methodologies like sulfo-click and seleno-click amidation.
- Recipient of the 2023 TIER1 Seed Grant for innovative drug discovery research
- Leading multidisciplinary projects with the Barnett Institute of Chemical and Biological Analysis
- Collaborations in both biomedical research and pharmaceutical sciences
Research trends emphasize translational applications of synthetic chemistry, with recent work exploring multifragment screening for protein interaction modulators and biocompatible reaction systems for targeted drug delivery. His lab’s publications consistently address critical gaps in treating neglected tropical diseases and antibiotic-resistant infections.
