معرفی
John E. Moses is a Professor at Cold Spring Harbor Laboratory (CSHL), where he leads the Moses Laboratory and serves as Faculty Head of the Mass Spectrometry Shared Resource for the Cancer Center. He is also a Cancer Center Member focusing on developing chemical tools for biological discovery, particularly in cancer research.
Dr. Moses earned his D.Phil. in Synthetic Organic Chemistry from the University of Oxford in 2004. His academic journey includes positions as Professor of Organic Chemistry at La Trobe University (2017-2020), Level 6 Future Fellow at the Australian Research Council (2017-2021), and Reader & Associate Professor in Organic Chemistry at the University of Nottingham (2007-2017).
Moses' research focuses on click chemistry, a powerful discovery method that uses robust chemical reactions to synthesize functional molecules. His lab specializes in developing and exploiting bond-forming click reactions for rapid synthesis of small functional molecules, including cancer drugs and chemical probes. They apply these molecular tools in multidisciplinary projects spanning biology and chemistry.
His recent work has led to significant advances in click chemistry methodologies, including Diversity Oriented Clicking (DOC) and Phosphorus Fluoride Exchange (PFEx). These approaches have enabled the discovery of new cancer therapeutics and antibiotics effective against multidrug-resistant bacteria like MRSA.
Dr. Moses has received numerous honors including the 2021 Organic Division Horizon Prize: Robert Robinson Award in Synthetic Organic Chemistry, Fellow of the Royal Society of Chemistry (2015), Thieme Chemistry Award (2011), and UK & ROI Lilly Award for Excellence in Organic Chemistry (2011).
Through his work at CSHL, Moses mentors students and postdoctoral researchers while collaborating with biologists to develop Chemistry For Biology. His lab's innovative approaches have been supported by multiple grants, including those from the National Cancer Institute.
The Moses Laboratory is at the forefront of click chemistry research, developing new methodologies while applying them to solve critical problems in cancer biology and antibiotic resistance.
