Jeff Aubé

Jeff Aubé, PhD, is a Professor at the University of North Carolina (UNC) at Chapel Hill, affiliated with the Eshelman School of Pharmacy and the Department of Chemistry. He serves as a member of the UNC Lineberger Comprehensive Cancer Center and directs the Aubé Laboratory, which integrates synthetic organic chemistry with chemical biology and drug discovery.

• Awards: Volwiler Research Achievement Award (2023), Edward Leete Award (2017), Midwest Award (2012), ACS Fellow (2012), Arthur C. Cope Scholar (2012), AAAS Fellow (2004).

Research Interests: The laboratory specializes in synthetic methodology development (e.g., intramolecular Schmidt reactions, heterocyclic chemistry) and natural product total synthesis, with applications in cancer, infectious disease, and neuroscience. Collaborative projects focus on designing small-molecule libraries for drug discovery, targeting RNA-binding proteins like HuR, and leveraging structural biology for fragment-based screening.

Publication Trends: Recent work spans Medicinal Chemistry (HuR inhibitors, opioid receptor modulators), Neuroscience (Angelman syndrome studies), Antimicrobial Research (tuberculosis drug targets), and Computational Drug Discovery (virtual screening workflows).

Laboratory: The Aubé Lab employs interdisciplinary approaches to address unmet medical needs, with expertise in organic synthesis, chemical biology, and collaborative translational research.