معرفی
Associate Professor David Anthony Jacques leads the Structural Virology Group at the EMBL Australia Node for Single Molecule Science, UNSW Sydney. He holds a PhD from the University of Sydney and completed postdoctoral research at the MRC Laboratory of Molecular Biology, Cambridge. His work focuses on structural biology of HIV and other viruses, employing techniques like X-ray crystallography, cryo-EM, and single-molecule fluorescence. Key research areas include HIV capsid structure-function relationships, host-pathogen interactions, and viral immune evasion mechanisms.
Education:
- PhD in Biochemistry, University of Sydney (supervised by Professors Jill Trewhella and Mitchell Guss)
- BSc (Advanced) (Hons) in Biochemistry and Chemistry
Research Interests: Structural basis of viral infection, HIV capsid dynamics, nuclear transport mechanisms, and development of antiviral strategies. His studies reveal how HIV exploits host machinery for replication and how viral proteins interact with cellular cofactors like nucleoporins and innate immune sensors.
Grants & Awards:
- NHMRC Early Career Fellowship (2012-2017)
- Wellcome Trust Collaborator Award (2019-2024)
- ARC Discovery Project (DP180101384)
Advising & Labs: Supervises Honours, Masters, and PhD students in virology and structural biology. Leads the Structural Virology Group with expertise in advanced microscopy and biophysical techniques. Collaborates on the X-ray Facility for Protein Crystallography funded under ARC LE190100165.
