جست‌وجوی استاد و پژوهشگر

Sophie Layéمشاهده پروفایل

استاد

• Neurobiology
• Nutritional Neuroscience
• Cognitive Aging
• +۷ مورد دیگر

Sophie Layé is a leading neurobiologist and Research Director at INRAE, affiliated with the University of Bordeaux and Bordeaux INP, where she directs the NutriNeuro institute. Her work bridges neuroscience and nutrition, focusing on how dietary components—particularly omega-3 fatty acids—influence brain health across the lifespan. Her research interests center on the role of nutrition in cognitive aging, depression, and neurodegenerative diseases. She explores how omega-3s modulate neuroinflammation and microglial function, and how dietary imbalances during gestation or postnatal periods may predispose individuals to neurodevelopmental and neurodegenerative disorders. Her work combines experimental models with clinical translational approaches to develop dietary interventions for brain health. The recent publications highlight a strong focus on omega-3 fatty acids, neuroinflammation, and brain development. Key themes include microglial phagocytosis, synaptic pruning, lipid metabolism in depression, and the developmental origins of brain disorders. The research spans molecular neuroscience, immunometabolism, and nutritional psychiatry, indicating a highly interdisciplinary and translational profile. Scientific Awards: INRAE Scientific Challenge Laureate (2015) Sophie Layé leads major research initiatives including the international Food4BrainHealth network and its associated OptiNutriBrain laboratory, fostering collaboration between French and Canadian researchers. She has secured significant research funding through INRAE and international partnerships, enabling large-scale studies on diet and brain function. She actively mentors researchers and contributes to public science communication through documentaries and media interviews. She is involved with the NutriNeuro laboratory, a joint research unit integrating expertise from INRAE, the University of Bordeaux, and Bordeaux INP. This team conducts cutting-edge research on the gut-brain axis, lipid neuroscience, and nutritional interventions for cognitive and mood disorders.

Mathilde Huskyمشاهده پروفایل

استاد

• Youth Mental Health
• Anxiety-Depressive Disorders
• Substance Use
• +۷ مورد دیگر

Mathilde Husky is a Professor of Clinical Psychology and Psychopathology at the University of Bordeaux, affiliated with the Faculty of Psychology. She leads the research axis on 'Social cognition: normal and psychopathological functioning' within the psychology laboratory and serves as the French national referent for the World Mental Health Survey Initiative (WHO). Her work bridges clinical practice, epidemiology, and digital mental health, with a focus on youth well-being. PhD in Psychology, University of Bordeaux (2004) Academic experience at Yale University and Columbia University (USA) Junior Member, Institut universitaire de France (2013–2018) Professor, University of Bordeaux (2016–present) Affiliation with University of Paris Descartes (2012–2016) Her research centers on youth mental health, particularly anxiety-depressive disorders, substance use, cyberbullying, and the psychological impact of social networks. She investigates how digital environments interact with traditional social dynamics to influence emotional regulation, academic performance, and mental health trajectories in children and adolescents. Her work emphasizes empirical data collection and the development of prevention strategies. The analysis of her recent publications reveals a sustained focus on adolescent mental health in digital contexts. Her research employs longitudinal designs, large-scale surveys, and epidemiological methods to explore the interplay between cyberbullying, social media use, and internalizing disorders. Key trends include the development of screening tools, methodological innovation in digital behavior measurement, and cross-national comparisons of mental health prevalence. Her scientific recognition includes: Junior Member of the Institut universitaire de France (2013–2018) Mathilde Husky leads the ANR-funded Cyberlife research project, a major cohort study involving 4,000 students from grades 5 to 9. This project examines the development of cyberbullying in relation to traditional bullying and investigates how social network use affects well-being, academic outcomes, and mental health. She also contributes to international research through the WHO-affiliated World Mental Health Survey Initiative, where she coordinates the student survey component in France. These roles indicate active grant leadership and research supervision, though specific advisees are not listed. She is a key figure in the psychology laboratory at the University of Bordeaux, where she directs a research axis on social cognition. Her work integrates clinical, cognitive, and epidemiological perspectives, contributing to both theoretical understanding and practical interventions in youth mental health.

• Second Language Acquisition
• Psycholinguistics
• Language Teaching Methodology
• +۹ مورد دیگر

Vanda Marijanovic is an Associate Professor in the Department of Language Sciences at the University of Toulouse - Jean Jaurès, where she conducts research and teaching in linguistics and second language acquisition, particularly in the context of French as a Foreign Language (FLE). She is affiliated with the NeuroPsychoLinguistics Laboratory (LNPL, EA 4156) and serves as co-responsible for the master's program ADFLE. Her academic work spans both theoretical and applied aspects of language learning, with a focus on early learners and psycholinguistic mechanisms. Her research interests include L2 literacy development, pronunciation, memory in language acquisition, and contrastive analysis. She explores how learners, especially children and adolescents, process and acquire a second language, drawing on methodologies from psycholinguistics and cognitive didactics. Her work investigates the interplay between oral and written language, phonological representations, and the influence of orthographic input on spoken output. The recent publications highlight a consistent focus on early language learners, particularly Croatian children acquiring French. Themes such as phonological processing, reading aloud, word identification, and the role of memory recur across her work. She frequently collaborates with researchers like M. Billières, C. Solier, and A. Krönert, contributing to international conferences such as EUROSLA, AFLS, and DIDCOG. Her publications appear in peer-reviewed journals, book chapters, and conference proceedings, reflecting active engagement in the academic community. She has contributed to educational outreach, including a MOOC on pronunciation teaching in FLE and public lectures such as 'Le cerveau à deux langues' during the Brain Awareness Week. While no specific awards are listed, her sustained research output and leadership in academic programs underscore her contributions to the field. In terms of teaching, she offers courses in FLE methodology, technology in language classrooms (TICE), cultural anthropology, general linguistics, and critical approaches to language teaching. She also teaches sociolinguistics and linguistic diversity within the broader linguistics curriculum. Her academic journey includes a PhD in Language Sciences from the University of Toulouse-Le Mirail, supported by a strong educational foundation from Sorbonne Nouvelle – Paris 3 and INALCO, where she studied Italian, Arabic, and foreign language pedagogy.

Philippe Connesمشاهده پروفایل

استاد

• Exercise Physiology
• Hematology
• Sickle Cell Disease
• +۷ مورد دیگر

Philippe Connes is a full Professor at Université Claude Bernard Lyon 1, where he leads the Vascular Biology and Red Blood Cell (VBRBC) team at the LIBM laboratory (EA7424). He previously held positions at the University of the French West Indies and served as a researcher at Inserm UMR 1134 in Guadeloupe. He is Vice-Dean of Doctorate School EDISS 205 and Scientific Research referent for the Constitutive Reference Center on Red Blood Cell Disorders in Lyon. PhD in Exercise Physiology and Hematology, Montpellier (2003) HDR, University of the French West Indies (2009) Junior Member, French University Institute (IUF) (2013) His research focuses on the cellular and physiological mechanisms underlying sickle cell disease and other hematological disorders, including hereditary spherocytosis and chronic mountain sickness. He investigates blood rheology, vascular function, autonomic nervous system activity, inflammation, and the effects of exercise on red blood cell physiology in both healthy individuals and patients. His work integrates clinical, physiological, and molecular approaches to understand disease complications and improve therapeutic strategies. The 15 most recent articles reflect a strong trend in sickle cell disease pathophysiology, red blood cell behavior, vascular dysfunction, and hemorheological adaptations to hypoxia and exercise. Key themes include inflammation, microcirculation, oxidative stress, and the role of nitric oxide metabolites. His publications span high-impact journals in hematology, physiology, and microcirculation. A.L. Copley Best Paper Prize 2019 A.L. Copley Best Paper Prize 2020 A.L. Copley Best Paper Prize 2023 Junior Member, French University Institute (IUF) Philippe Connes has supervised over 20 PhD and postdoctoral researchers and secured funding from diverse sources including the French National Research Agency (ANR), German Research Foundation (DFG), European H2020 programs, Marie-Curie ITN, and private pharmaceutical companies like Erytech Pharma and Hartis Pharma. He is actively involved in editorial work for Clinical Hemorheology and Microcirculation , Frontiers in Physiology , and PLOS ONE , and holds leadership roles in the European Society of Clinical Hemorheology and Microcirculation (ESCHM), the French Club of the Red Blood Cell and Iron, and the International Society for Clinical Hemorheology (ISCH). He leads the VBRBC research team at LIBM, focusing on vascular biology and red blood cell disorders, with strong collaborations across national and international institutions.

Quentin Giai Gianettoمشاهده پروفایل

پژوهشگر

• Proteomics
• Mass Spectrometry
• Bioinformatics
• +۳ مورد دیگر

Quentin Giai Gianetto is a Researcher at the Institut Pasteur in Paris, France, where he has been working since September 2016. He is affiliated with the Bioinformatics and Biostatistics HUB and is detached to the Proteomics facility. He holds a PhD in Signal Processing from Telecom Bretagne (now IMT Atlantique) and a Master in Mathematics with a specialty in Statistical Engineering from Rennes 1 University. His research interests span Proteomics, Mass Spectrometry, Bioinformatics, Biostatistics, and Data Analysis. He focuses on developing new methodologies to optimize proteomics data analysis pipelines, from the identification of peptides/proteins to their quantification and the interpretation of results. He has developed several R packages including cp4p, imp4p, DAPAR (with its GUI ProStar), and MSclassifR. His publication record demonstrates expertise across multiple domains. In virology, he has contributed to influenza A virus research, investigating viral ribonucleoprotein egress and host-virus interactions. In microbiology, his work spans Vibrio cholerae antibiotic tolerance mechanisms, Bordetella pertussis fimbriae characterization, and Mycobacterium abscessus subspecies identification. His cell biology research includes mitochondrial function studies related to hepatic steatosis and heart failure, as well as tunnelling nanotube formation. He has also contributed to parasitology research on Leishmania and Trypanosoma brucei. At the Institut Pasteur, Giai Gianetto has been actively involved in education, contributing to the Bioinformatics program for PhD students and multiple Introduction to Data Analysis courses, as well as a specialized course on Quantitative Proteomic Analysis.

• Biostatistics
• Multivariate Statistics
• Data Visualization
• +۷ مورد دیگر

Vincent Guillemot is a biostatistician at the Hub of Bioinformatics and Biostatistics, Institut Pasteur, Paris. He holds a PhD in multivariate data analysis and has held postdoctoral positions at NeuroSpin (Saclay), Ludwig Maximilian University (Munich), and the Brain and Spine Institute (Paris). His work focuses on statistical data integration, machine learning, and bioinformatics. His research expertise includes: Biostatistics and multivariate statistics Data visualization and statistical inference Machine learning for biological data Statistical data integration in genomics and imaging Analysis of high-throughput datasets (e.g., microarray, RNA-seq) His recent publications span fields such as immunology, neurogenetics, virology, and public health, reflecting a strong interdisciplinary approach. Trends in his work show a focus on integrating complex biological datasets to uncover mechanisms in disease and immunity, particularly through advanced statistical modeling and network analysis. He is actively involved in teaching and training, including: Coordinator and instructor in the Bioinformatics program for PhD students (INCEPTION program) Teaching courses on R programming, data analysis, and statistics Leading the Data Integration Group at the Hub He has not received any scientific awards mentioned in the text. He supervises no explicitly named students but contributes to training numerous PhD candidates through structured programs. He is involved in the INCEPTION program, which promotes integrative biology, data science, and social sciences to understand disease emergence. His leadership in the Data Integration Group supports methodological development and knowledge sharing within the bioinformatics community at Institut Pasteur.

Sébastien MELLAمشاهده پروفایل

پژوهشگر

• Bioinformatics
• Genomics
• Single-cell RNA sequencing
• +۴ مورد دیگر

Sébastien Mella is a researcher at Institut Pasteur in Paris, France, with extensive involvement in bioinformatics education and research. He has co-instructed multiple training programs for PhD students including: Bioinformatics program for PhD students 2023-2024 Bioinformatics program for PhD students 2022-2023 Bioinformatics program for PhD students 2020-2021 Introduction to R and statistics – RS1 courses (2021-2022) He contributes to the Bioinformatics and Biostatistics HUB and participates in single-cell transcriptomics projects through collaborative efforts with the CB UTechS and Biomics platforms. His research interests span immunology, genomics, and developmental biology, with recent publications focusing on: Immune signatures in dengue virus infection SARS-CoV-2 pathogenesis mechanisms Human mucosal-associated invariant T cell regulation Mouse embryonic development signaling pathways Intestinal immune cell dynamics in genetic disorders Mella actively publishes in high-impact journals like Cell Host Microbe, iScience, and Frontiers in Immunology. His work utilizes advanced techniques including single-cell RNA-seq, bulk RNA-seq, and statistical analysis of genomic data.

Marie-Agnès Dilliesمشاهده پروفایل

پژوهشگر

• Biostatistics
• Transcriptomics
• RNA-seq Analysis
• +۳ مورد دیگر

Marie-Agnès Dillies is a Researcher at Institut Pasteur's Department of Computational Biology, where she currently serves as interim manager of the Bioinformatics and Biostatistics Hub (since July 2020) and co-manages the StatOmique consortium of French statisticians. Previously, she was co-head of the Hub (2015-2020) and a statistician at the Transcriptome and Epigenome Platform (2002-2017). Her education includes a PhD in Control of Complex Systems (UTC, 1993), Master's in Functional Genomics (Paris Diderot, 2002), and an Engineering degree in Biomedical Engineering (UTC, 1989). Dr. Dillies specializes in biostatistical methods for high-throughput biological data, with research interests spanning: Transcriptomics and RNA-seq analysis Experimental design optimization Single-cell data interpretation Statistical inference frameworks Bioinformatics tool development Her recent publications demonstrate strong focus on pathogen genomics (Entamoeba, Lassa virus), host-pathogen interactions , and development of computational tools for mass spectrometry data. Research consistently integrates statistical approaches with molecular biology techniques. She leads significant training initiatives including PhD courses in bioinformatics and coordinates the Institut Pasteur's bioinformatics program. Current projects include biostatistical support for transcriptomics studies and technological developments in data analysis pipelines.

• Epigenetics
• Chemical Biology
• Medicinal Chemistry
• +۷ مورد دیگر

Paola B. Arimondo is a Professor and research group leader at the Institut Pasteur in Paris, where she heads the Epigenetic Chemical Biology Unit within the Department of Structural Biology and Chemistry. She is also the administrative director of the joint CNRS-Institut Pasteur Research Unit UMR3523 (Chem4Life). Her work bridges chemistry and biology to develop innovative chemical probes and therapeutic strategies targeting epigenetic mechanisms in cancer and infectious diseases. Institution: Institut Pasteur Research Unit: UMR3523 CNRS-Institut Pasteur (Chem4Life) Department: Epigenetic Chemical Biology Unit Leadership: Administrative Director of UMR3523 Teaching: Involved in Master’s programs and the Pasteur-Paris University-Oxford PhD exchange program Her research focuses on epigenetic regulation, particularly DNA and histone methylation. She designs chemical inhibitors and probes to reprogram gene expression in cancer cells and to study host-pathogen interactions. Her interdisciplinary approach integrates medicinal chemistry, biochemistry, and molecular biology. The recent articles highlight a strong trend in targeting epigenetic enzymes like DNMT1 and MBD2, using computational and synthetic methods to develop novel anticancer agents. There is also a focus on chemical probe development for mechanistic studies in epigenetics, with applications in cancer, stem cells, and infectious diseases. Collaborative work spans chemical synthesis, structural studies, and functional genomics. She is actively involved in major collaborative research projects, including the DIM1HEALTH EpiK project on the cytosine code in disease. Her work is supported by Institut Pasteur and regional funding agencies. She mentors students and postdoctoral researchers and collaborates with a wide network of national and international scientists in epigenetics, cancer biology, and infectious diseases. She organizes scientific events and seminars, contributing to the academic community. Her research unit operates advanced facilities for mass spectrometry-based detection of nucleic acid modifications and collaborates with core platforms for high-throughput screening and chemical biology. She is part of a vibrant interdisciplinary environment at Institut Pasteur focused on chemistry for life sciences.

• Microfluidics
• Bioengineering
• Quantitative Biology
• +۷ مورد دیگر

Charles Baroud is a Professor at École Polytechnique and Head of the Pasteur-Polytechnique Joint Research Group on Physical Microfluidics and Bioengineering at the Institut Pasteur, Paris, within the Genomes and Genetics Department. His interdisciplinary research bridges physics, engineering, and biology, leveraging microfluidic technologies to study cellular systems at single-cell resolution. Education: B.Sc., MIT (1994) Ph.D., University of Texas at Austin (2001) Post-doctoral training, École Normale Supérieure, Laboratoire de Physique Statistique (2002) His research focuses on quantitative biology , developing microfluidic platforms to investigate antibiotic resistance in bacterial populations , 3D cell culture (spheroids and organoids) , and cancer immunotherapy using organ-on-a-chip models . His lab has pioneered droplet-based microfluidic systems for encapsulating and monitoring single cells under controlled conditions, enabling precise measurements of cellular heterogeneity and response dynamics. His recent publications (2023–2025) reveal a strong trend in applying microfluidics to stem cell biology , developmental hematopoiesis , and T-cell cytotoxicity . Notably, his work on the APC mutation’s impact on T-cell engagement in tumor killing and on SUMOylation in embryonic stem cells has been published in high-impact journals such as PNAS , Science Advances , and Cell Reports . Scientific Recognition: Co-founder of Stilla Technologies (2013), demonstrating successful technology transfer. Supervision of multiple PhD students and postdocs, several of whom have won the École Polytechnique thesis prize. Former group members have founded three startup companies and secured faculty positions internationally. Baroud leads several ongoing projects including Measuring single-cell susceptibility to antibiotics , Quantitative microbiology , 3D cell culture: spheroids and organoids , and Technology transfer: Making 3D cell culture available to all . His lab is part of broader transversal initiatives at Institut Pasteur, including the IP Stem Cell Initiative , Quantitative Biology program, and Antimicrobial Resistance efforts. He is actively involved in mentoring and research leadership, with no indication of retirement or part-time status. While no specific scientific awards are listed in the text, his influence is evident through the success of his trainees and the translational impact of his work.

• Fungal Biology
• Pathogenicity
• Host-pathogen interactions
• +۷ مورد دیگر

Christophe D’Enfert is a Professor at Institut Pasteur and Head of the Fungal Biology and Pathogenicity Unit, which operates within the Mycology Department and the Department of Genomes and Genetics. His research focuses on the biology, pathogenicity, and genomics of Candida albicans and other pathogenic yeasts, with a strong emphasis on biofilm formation, morphogenesis, and host-microbiota interactions. He is affiliated with the National Institute for Agronomic Research (INRAE) and collaborates internationally, including with the University of Aberdeen. PhD in Molecular Biology, Institut Pasteur His research interests center on the mechanisms underlying fungal infections, particularly in immunocompromised individuals. He investigates C. albicans genomic diversity, colonization of biotic and abiotic surfaces, and regulation of morphogenesis. His lab uses functional genomics, high-throughput screening, and molecular biology to dissect virulence mechanisms and antifungal resistance. The recent publications reflect a strong trend in understanding fungal cell wall architecture, metabolic adaptation in biofilms, host-fungal-microbiota interplay, and genomic basis of virulence and resistance. His work spans molecular microbiology, systems biology, and translational medical mycology. Coordinator, Marie Sklodowska-Curie Initial Training Network (FunHoMic) Funded by Swiss National Science Foundation (Sinergia program) Christophe D’Enfert leads multiple research grants and mentors several PhD students and postdoctoral researchers. His lab is part of major transversal projects at Institut Pasteur, including INCEPTION, focused on integrative biology and data science. He contributes to educational initiatives such as the MOOC on Medical Mycology and specialized courses in molecular genetics and epigenetics. His team develops advanced genomic tools like the C. albicans ORFeome and barcoded strain collections, fostering collaborative research across Europe. He leads or co-leads multiple ongoing projects including FunHoMic, CANDIHUB, Candida genomic diversity, biofilm colonization, and morphogenesis regulation. His lab, located at 25-28 Rue du Docteur Roux in Paris, is equipped with state-of-the-art instrumentation for microbiology, genomics, and imaging, supporting a multidisciplinary approach to fungal pathogenesis.

Marc Delarueمشاهده پروفایل

استاد

• Structural Biology
• Computational Structural Biology
• DNA Repair
• +۱۲ مورد دیگر

Marc Delarue is a Professor and Head of Structure at the Laboratory of Architecture and Dynamics of Biological Macromolecules, part of the Department of Structural Biology and Chemistry at the Institut Pasteur in Paris, France. He leads multiple research projects focused on DNA repair, DNA replication, ion channels, and computational structural biology. Institution: Institut Pasteur School: Department of Structural Biology and Chemistry Department: Architecture and Dynamics of Biological Macromolecules Role: Head of Structure, Principal Investigator His research integrates experimental and computational approaches, including X-ray crystallography, cryo-EM, molecular dynamics, and electrostatic modeling, to understand macromolecular structure-function relationships. Key interests include DNA polymerases, NHEJ repair in cancer, ligand-gated ion channels, and the development of simulation software such as MinActionPath and NOMAD-Ref. The recent publications highlight a strong trend in structural mechanisms of DNA-processing enzymes, ion channel pharmacology, and computational modeling of macromolecular transitions. These works frequently appear in high-impact journals and involve collaborations across disciplines and institutions. Marc Delarue has mentored numerous PhD students and postdoctoral researchers, including Jérémie Piton, Jerome Gouge, Frederic Poitevin, and Leonardo Betancurt Anzola. His projects are supported by internal and transversal funding initiatives at the Institut Pasteur, such as the Cancer Initiative and INCEPTION convergence program, though specific grant names are not detailed. He is actively involved in software development for structural bioinformatics, leading projects like MinActionPath and NOMAD-Ref, which are used to simulate conformational changes and analyze dynamics in large macromolecular complexes.

Agathe Subtilمشاهده پروفایل

پژوهشگر

• Host-pathogen interactions
• Cell biology
• Intracellular bacteria
• +۱۱ مورد دیگر

Agathe Subtil is a Research Director at the Centre National de la Recherche Scientifique (CNRS) and leads the 'Genome Integrity, Immunity and Cancer' unit at the Institut Pasteur in Paris. Her research focuses on host-pathogen interactions, particularly the intracellular bacterium Chlamydia , including C. trachomatis and C. pneumoniae , which cause diseases such as trachoma, pelvic inflammatory disease, and pneumonia. Her work explores the mechanisms of bacterial entry, intracellular survival, and the manipulation of host cell processes such as membrane trafficking, autophagy, and nuclear functions. She investigates how Chlamydia infection leads to DNA damage and inflammation, with implications for cervical cancer development. Her lab also studies the evolutionary connections between Chlamydia and plant organelles. The 15 most recent publications highlight consistent research themes: Chlamydia 's manipulation of host metabolism (glycolysis, oxidative phosphorylation), immune evasion (via ISG15), effector protein function (e.g., CT622, CT295), and organelle remodeling (endosomes, inclusion membrane). Techniques include cell culture, microscopy, molecular biology, and metabolic labeling. ERC-2011-StG NUChLEAR grant She mentors several PhD students and postdoctoral researchers, including Camille Dos Santos-Toinet, Klementina Borovnik, and Yongzheng Wu. She has received significant research funding, notably an ERC Starting Grant. Her team operates within state-of-the-art facilities at the Institut Pasteur, engaging in transversal projects such as drug discovery and cancer research. The laboratory investigates the biogenesis of the Chlamydia inclusion, the role of type III secretion effectors, and the long-term consequences of infection, such as infertility and oncogenesis. The team collaborates across disciplines and participates in broader initiatives like the Institut Pasteur's Cancer Initiative and Antimicrobial Resistance programs.

Gérard Eberlمشاهده پروفایل

استاد

• Immunology
• Mucosal Immunity
• Innate Lymphoid Cells (ILCs)
• +۷ مورد دیگر

Gérard Eberl is a Professor and the Structure Manager Responsible at the Institut Pasteur in Paris, leading the research unit on Microenvironment and Immunity. His work is central to understanding the complex interactions between the host immune system, the gut microbiota, and the nervous system. Position: Professor, Structure Manager Responsible Institution: Institut Pasteur Department: Microenvironment and Immunity Contact: gerard.eberl@pasteur.fr His research focuses on the fundamental role of the symbiotic microbiota in host physiology, particularly in the development and regulation of the immune system. He investigates the function of Innate Lymphoid Cells (ILCs) in mucosal defense and tissue homeostasis, and explores the emerging field of neuroimmunology, where he has demonstrated direct communication between gut bacteria, the enteric nervous system, and systemic immune and metabolic responses. His recent publications reveal a strong trend in the intersection of immunology, microbiology, and neuroscience. His work frequently examines how microbial signals are sensed by neurons (e.g., via Nod2) to regulate appetite and inflammation, and how the brain responds to peripheral immune signals (e.g., IL-1β) to modulate systemic physiology. His research program is highly interdisciplinary, bridging mucosal immunology, microbial ecology, and neurobiology. Dr. Eberl has supervised numerous PhD students and post-doctoral fellows, contributing significantly to training the next generation of scientists in the field of immunology and host-microbe interactions. His leadership in major projects like 'Symbiotic microbiota and the development and regulation of the immune system' and 'The role of Intestinal lymphoid cells (ILCs) in defense and physiology' underscores his prominent role in the research community. He is involved in collaborative research environments, including the 'Microbes & Brain' Grand Programme Fédérateur, which brings together international teams in neuroscience and immunology. His work is supported by significant funding from initiatives such as LabEx IBEID and the 'When Gut Bacteria Changes Brain Functions' project.

• Bioinformatics
• Biostatistics
• Computational Biology
• +۵ مورد دیگر

Laurent Essioux and Hervé Ménager co-lead the Bioinformatics and Biostatistics Hub at Institut Pasteur, providing computational biology support to the institute's research units and platforms. The Hub is structured into five specialized centers: AIM (AI and Mathematical Modeling), FUNOMICA (Functional and OMICs Analysis), PAGE (Phylogeny, Algorithms, Genomics, Evolution), STATS (Statistics), and WISPR (Web Integration, Scientific Programming and Reproducibility). Their research spans multiple computational biology domains including: Bioinformatics methodologies and biostatistics Machine learning applications in biological data analysis Genomic and metagenomic data processing Statistical experimental design Development of specialized bioinformatics software tools The Hub offers three-tiered support: free assistance for projects under 3 months, subsidized support (3k€/month) for longer strategic projects, and potential staff detachment for extended collaborations. They maintain an open desk every Tuesday morning for direct researcher support and have developed numerous software tools including ToolDog, Bioconvert, and SHADE. Both leaders actively participate in educational initiatives, teaching PhD courses in bioinformatics and biostatistics through the institute's training programs. Their work facilitates cutting-edge research across the Institut Pasteur by bridging computational methods with biological discovery.