معرفی
Christophe D’Enfert is a Professor at Institut Pasteur and Head of the Fungal Biology and Pathogenicity Unit, which operates within the Mycology Department and the Department of Genomes and Genetics. His research focuses on the biology, pathogenicity, and genomics of Candida albicans and other pathogenic yeasts, with a strong emphasis on biofilm formation, morphogenesis, and host-microbiota interactions. He is affiliated with the National Institute for Agronomic Research (INRAE) and collaborates internationally, including with the University of Aberdeen.
- PhD in Molecular Biology, Institut Pasteur
His research interests center on the mechanisms underlying fungal infections, particularly in immunocompromised individuals. He investigates C. albicans genomic diversity, colonization of biotic and abiotic surfaces, and regulation of morphogenesis. His lab uses functional genomics, high-throughput screening, and molecular biology to dissect virulence mechanisms and antifungal resistance.
The recent publications reflect a strong trend in understanding fungal cell wall architecture, metabolic adaptation in biofilms, host-fungal-microbiota interplay, and genomic basis of virulence and resistance. His work spans molecular microbiology, systems biology, and translational medical mycology.
- Coordinator, Marie Sklodowska-Curie Initial Training Network (FunHoMic)
- Funded by Swiss National Science Foundation (Sinergia program)
Christophe D’Enfert leads multiple research grants and mentors several PhD students and postdoctoral researchers. His lab is part of major transversal projects at Institut Pasteur, including INCEPTION, focused on integrative biology and data science. He contributes to educational initiatives such as the MOOC on Medical Mycology and specialized courses in molecular genetics and epigenetics. His team develops advanced genomic tools like the C. albicans ORFeome and barcoded strain collections, fostering collaborative research across Europe.
He leads or co-leads multiple ongoing projects including FunHoMic, CANDIHUB, Candida genomic diversity, biofilm colonization, and morphogenesis regulation. His lab, located at 25-28 Rue du Docteur Roux in Paris, is equipped with state-of-the-art instrumentation for microbiology, genomics, and imaging, supporting a multidisciplinary approach to fungal pathogenesis.
