معرفی
Mélanie Legrand is a permanent researcher at the Institut Pasteur, where she is integrated into the Fungal Biology and Pathogenicity Unit led by Professor Christophe d’Enfert. She obtained her Master's and PhD from the University of Minnesota, focusing on mating and DNA repair in human fungal pathogens Candida albicans and C. dubliniensis. She secured a permanent position at INRA in 2010 and continues her research at the Institut Pasteur on genome integrity and plasticity in C. albicans.
Her research interests include Candida albicans general biology, genome dynamics, mating mechanisms, and the regulation of loss of heterozygosity (LOH). She leads a project identifying regulators of LOH and contributes to the C. albicans ORFeome project. Her work lies at the intersection of molecular genetics, fungal pathogenesis, and genome evolution.
The analysis of her recent publications (2019–2024) reveals a consistent focus on genome plasticity, DNA repair, transcriptional regulation in biofilm formation, antifungal tolerance, and the role of stochastic processes in genome dynamics in diploid fungi. Her studies employ advanced techniques such as CRISPR-Cas9 genome editing, transcriptomics, and functional genomics, positioning her at the forefront of fungal molecular biology research.
She has not been mentioned to have received any specific scientific awards in the provided text.
Mélanie Legrand collaborates extensively with leading scientists in the field, including Christophe d’Enfert, Kasturi Sanyal, and others. Although no formal advisees are listed, her leadership in key projects suggests active mentorship and team coordination. There is no mention of grants in the provided texts.
She is a core member of the Fungal Biology and Pathogenicity Unit, which is a collaborative and multidisciplinary research team focused on understanding the biology and pathogenic mechanisms of fungal pathogens, particularly Candida species, using cutting-edge genomic and molecular tools.
