معرفی
Charles Baroud is a Professor at École Polytechnique and Head of the Pasteur-Polytechnique Joint Research Group on Physical Microfluidics and Bioengineering at the Institut Pasteur, Paris, within the Genomes and Genetics Department. His interdisciplinary research bridges physics, engineering, and biology, leveraging microfluidic technologies to study cellular systems at single-cell resolution.
Education:
- B.Sc., MIT (1994)
- Ph.D., University of Texas at Austin (2001)
- Post-doctoral training, École Normale Supérieure, Laboratoire de Physique Statistique (2002)
His research focuses on quantitative biology, developing microfluidic platforms to investigate antibiotic resistance in bacterial populations, 3D cell culture (spheroids and organoids), and cancer immunotherapy using organ-on-a-chip models. His lab has pioneered droplet-based microfluidic systems for encapsulating and monitoring single cells under controlled conditions, enabling precise measurements of cellular heterogeneity and response dynamics.
His recent publications (2023–2025) reveal a strong trend in applying microfluidics to stem cell biology, developmental hematopoiesis, and T-cell cytotoxicity. Notably, his work on the APC mutation’s impact on T-cell engagement in tumor killing and on SUMOylation in embryonic stem cells has been published in high-impact journals such as PNAS, Science Advances, and Cell Reports.
Scientific Recognition:
- Co-founder of Stilla Technologies (2013), demonstrating successful technology transfer.
- Supervision of multiple PhD students and postdocs, several of whom have won the École Polytechnique thesis prize.
- Former group members have founded three startup companies and secured faculty positions internationally.
Baroud leads several ongoing projects including Measuring single-cell susceptibility to antibiotics, Quantitative microbiology, 3D cell culture: spheroids and organoids, and Technology transfer: Making 3D cell culture available to all. His lab is part of broader transversal initiatives at Institut Pasteur, including the IP Stem Cell Initiative, Quantitative Biology program, and Antimicrobial Resistance efforts.
He is actively involved in mentoring and research leadership, with no indication of retirement or part-time status. While no specific scientific awards are listed in the text, his influence is evident through the success of his trainees and the translational impact of his work.
