معرفی
Giulia Manina is a Researcher and Structure Manager leading the Microbial Individuality and Infection group at the Department of Microbiology, Institut Pasteur, Paris, France. Her research focuses on understanding phenotypic heterogeneity in Mycobacterium tuberculosis and its role in infection, persistence, and antibiotic resistance. She employs a multidisciplinary approach integrating classical microbiology, genetics, and advanced single-cell technologies including microfluidics, real-time epifluorescence microscopy, and FACS-based analysis.
Her research interests include microbial individuality, bacterial quiescence, DNA damage response, host-pathogen interactions, and the development of novel therapeutic strategies for tuberculosis. She investigates how metabolic and genetic heterogeneity at the single-cell level contributes to long-term persistence and reactivation of latent infections. Her work aims to identify molecular markers of dormancy and new drug targets to improve treatment outcomes.
The recent articles highlight a consistent focus on single-cell dynamics of M. tuberculosis under stress and drug exposure. Key themes include phenotypic heterogeneity, microfluidic screening platforms, DNA repair mechanisms, and the discovery of compounds that modulate bacterial phenotypes to enhance antibiotic efficacy. Her research bridges fundamental microbiology with translational applications in infectious disease control.
Scientific Awards:
- No scientific awards mentioned in the provided text.
Advising and Grants:
Giulia Manina has supervised numerous students and postdoctoral fellows, including undergraduate students, graduate students, and postdocs. She leads multiple research projects funded by major initiatives such as the Labex IBEID (Integrative Biology of Emerging Infectious Diseases) and the Carnot Pasteur Microbes and Santé program. Her projects include 'Impact of the host on microbial individuality', 'DNA damage response', 'Molecular markers for cell quiescence', and 'Single-cell gene expression dynamics', indicating sustained grant support for her research program.
Labs and Teams:
She leads the 'Microbial Individuality and Infection' research team at the Institut Pasteur, which includes research engineers, technicians, postdoctoral fellows, and administrative staff. The team utilizes advanced platforms such as microfluidics, bioimage analysis, and single-cell data analysis. She collaborates within cross-functional projects on emerging infectious diseases and antimicrobial resistance, and is part of the broader scientific ecosystem at the Institut Pasteur focused on host-mimicking platforms and infection biology.
