جست‌وجوی استاد و پژوهشگر

Itys Vacher-Cometمشاهده پروفایل

پژوهشگر ارشد

• Chromatin
• Epigenetics
• Polycomb proteins
• +۵ مورد دیگر

Itys Vacher-Comet is a Research Fellow at the Biotech Research & Innovation Centre (BRIC), University of Copenhagen, working in the laboratory of Prof. Kristian Helin since May 2009. He holds a Ph.D. in Biochemistry and Molecular Biology from Montpellier I, Medicine University, France (2007) and an M.Sc. in Chemical and Biological Sciences for Health from Montpellier II, Sciences and Techniques University, France (2002). Dr. Vacher-Comet's research focuses on elucidating the molecular mechanisms of Polycomb group (PcG) proteins in mammals. His work explores how chromatin structure and epigenetic regulation influence gene silencing, cell identity, differentiation, and cancer development. His research combines molecular biology, chromatin analysis, and genomic approaches to understand the recruitment mechanisms of PcG proteins in embryonic stem cells and during cellular differentiation. Analysis of his publication record from 2011-2023 reveals a consistent focus on Polycomb-mediated gene regulation, chromatin architecture, and cancer epigenetics. His work spans basic molecular mechanisms of chromatin organization to translational applications in cancer therapy, particularly in pediatric gliomas. The research demonstrates increasing emphasis on therapeutic applications of epigenetic knowledge in recent years. Lundbeck foundation grant (2012-2015, EUR 201k) EMBO Long-Term Fellowship (2010-2012) French National League against Cancer fellowship (2005-2006) French ministry of scientific research fellowship (2002-2005, ranked first out of 48) Dr. Vacher-Comet has mentored two master's students at University Montpellier II (2006-2007) and delivered lectures on epigenetics and structural biochemistry. His laboratory management training through the EMBO Laboratory Management Course for Postdocs (2013) supports his research leadership within Prof. Helin's internationally recognized laboratory at BRIC.

Ryan Hiliمشاهده پروفایل

دانشیار

• Chemical Biology
• Combinatorial Chemistry
• Organic Chemistry
• +۴ مورد دیگر

Ryan Hili is an Associate Professor in the Department of Chemistry at York University, holding a York Research Chair (Tier 2). He leads the Hili Group, which focuses on chemical biology, combinatorial chemistry, and organic chemistry at the interface of chemistry and biology. His research integrates synthetic organic chemistry with molecular biology to develop DNA-encoded library technologies for drug discovery, small-molecule catalysts, and biomarker profiling. The group is affiliated with the Centre for Research on Biomolecular Interactions (CRBI). Research interests include molecular evolution, DNA-encoded libraries, and epitranscriptomics. The Hili Group employs enzymatic methods and high-throughput DNA sequencing to screen millions of molecules for functional properties, emphasizing interdisciplinary collaboration. Recent work addresses N2-methylation in RNA and ligase-catalyzed polymerization techniques for aptamer evolution. Awards: York Research Chair (Tier 2) Labs: Hili Lab, CRBI Key Technologies: LOOPER (ligase-catalyzed oligonucleotide polymerization), PhOxi-seq Advising and grants focus on training interdisciplinary researchers. Ongoing projects explore synthetic nucleic acid polymers, RNA modifications, and enzyme-free translation systems.

Andreas Brunschweigerمشاهده پروفایل

استاد

• DNA-encoded libraries
• Macrocycles
• Data science
• +۶ مورد دیگر

Professor Andreas Brunschweiger serves as Chair of Pharmaceutical Chemistry within the Institute of Pharmacy and Food Chemistry at the University of Würzburg's Faculty of Chemistry and Pharmacy. His research group operates from Hubland Campus (Room 01.004) with administrative support from Jana Müller. His primary research focuses on DNA-encoded libraries (DEL) for drug discovery, where he pioneers chemically stabilized DNA systems and nanoheterogeneous platforms. Additional expertise spans macrocyclic compound development , data science applications in chemical reaction spaces , and lipid nanoparticle engineering for mRNA vaccine delivery systems. His team actively develops TEAD-YAP protein-protein interaction inhibitors and novel biodegradable compounds including chemically modified lipids and PEGylated lipid substitutes. DEL Technologies: Screening complex compound mixtures via DNA sequencing for target protein binders Lipid Research: Designing stable, biodegradable lipid nanoparticles for tissue-specific drug delivery Data Science: Statistical analysis of DEL selections and reaction space modeling Professor Brunschweiger maintains active research collaborations in translational pharmaceutical sciences with emphasis on sustainable drug discovery methodologies. His laboratory infrastructure supports nucleic acid-based therapeutic development and compound validation assays.

Jan Vogesمشاهده پروفایل

پژوهشگر

• Genomic Data Compression
• DNA Data Storage
• Bioinformatics
• +۳ مورد دیگر

Dr. Jan Voges is a Research Group Leader at the Institute for Information Processing and the L3S Research Center at Leibniz University Hannover, where he leads the BioAI Lab. He has held previous research leadership positions at the same institution (2022-2024), CIMA University of Navarra (2024-2025), and maintains a visiting position at the Peter L. Reichertz Institute for Medical Informatics. Dr. Voges' research spans the intersection of computer science, genomics, and medical informatics, with a focus on: Developing AI methods for multi-omics data analysis DNA sequencing data compression and storage 3D genome reconstruction Single-cell RNA sequencing data modeling International standardization of genomic data His recent work demonstrates a strategic shift toward integrating artificial intelligence with genomic data analysis, particularly for medical applications. The development of Genie, the first open-source ISO/IEC encoder for genomic data, represents a significant contribution to genomic data standards. His research shows strong translational potential, bridging computational methods with clinical applications as evidenced by his P4D Dashboard project for depression cohort monitoring. Dr. Voges has received recognition for his work, most notably earning his Dr.-Ing. degree with distinction in 2022. His active participation in ISO/IEC standardization committees and collaborations with international institutions demonstrates the impact of his work beyond traditional academic boundaries. As a supervisor, Dr. Voges maintains a focused lab structure with 3 PhD students, emphasizing quality mentorship and opportunities for students to contribute to high-impact projects with real-world applications. His lab provides unique opportunities at the cutting edge of genomic data science, with exposure to international standardization processes and interdisciplinary collaborations.

Ken Pearceمشاهده پروفایل

استاد پژوهشی

• Early drug discovery
• Oncology
• Epigenetic targets
• +۴ مورد دیگر

Ken Pearce is a Research Professor at the UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. He leads an interdisciplinary team focused on early-stage drug discovery, particularly in oncology and epigenetic pathways. Education: No explicit educational details are provided in the text. Research Interests: His laboratory integrates reagent production, assay development, high-throughput screening, biophysics, and exploratory cell biology to identify small-molecule chemical probes and therapeutics. Specific areas include inhibition of chromatin methyl-lysine reader proteins, targeting small GTPases (e.g., K-Ras, Gaq), inositol phosphate kinases, and protein–protein interactions involving CIB1 and MAGE proteins. They also pursue phenotypic screens—such as enhancing c-Myc degradation in pancreatic cancer cells—and are advancing DNA-encoded library technologies as a complement to traditional high-throughput approaches. Publication Trends: Recent articles (2022–2025) emphasize chemical biology, structure-guided drug design, epigenetic modulators, and immunotherapy. Earlier work (2004) focused on structural characterization of nuclear receptors. The trajectory illustrates a consistent focus on translating biochemical insights into therapeutic leads for cancer, neurodegeneration, and inflammatory diseases. Funding & Collaborations: Pearce actively partners with the Center for Integrative Chemical Biology and Drug Discovery and multiple groups across the UNC campus, leveraging shared resources and expertise to accelerate translational research. Laboratory & Teams: He directs a comprehensive collaborative group housed in Marsico Hall, Chapel Hill, NC, equipped for high-throughput screening, biophysical characterization, and cellular imaging.

Jenny Chenمشاهده پروفایل

پژوهشگر ارشد

• Behavioral Genetics
• Computational Genomics
• Evolutionary Biology
• +۳ مورد دیگر

Jenny Chen is an NIH K99/R00 MOSAIC Scholar and former Harvard Data Science Fellow. She holds a PhD in Bioinformatics and Integrative Genomics from MIT, advised by Aviv Regev. Currently affiliated with Harvard University, her research focuses on understanding the genetic basis of innate behaviors using comparative genomics, single-cell transcriptomics, and computational methods. Her work combines experimental and computational approaches to study behavioral evolution in rodents and discover novel neuropeptides. Education: PhD in Bioinformatics, MIT (Advisor: Aviv Regev) Postdoctoral Training: Hoekstra Lab & Eddy Lab, Harvard University Research Interests: Dr. Chen investigates how genes encode behavioral traits, particularly reproductive behaviors in deer mice (Peromyscus species). Her lab explores two major areas: (1) genetic mechanisms of mating and parental care behaviors, and (2) computational discovery of conserved neuropeptides. She uses advanced techniques like single-nucleus RNA-sequencing, immunostaining, and machine learning to identify molecular pathways governing behavior. Teaching: She has taught Molecular Biology and Genetics at MIT/Harvard Medical School and emphasizes active learning through real-world data analysis and ethical discussions on CRISPR technology. Her mentoring philosophy prioritizes fostering creativity, resilience, and scientific independence in students. Labs & Collaborations: Collaborates with the Hoekstra Lab (behavioral genetics) and Eddy Lab (computational biology). Her independent lab will continue investigating neuronal cell-type evolution and neuropeptide functions.

Hacer Karatas Bristowمشاهده پروفایل

استادیار

• Medicinal Chemistry
• Protein-Protein Interaction Inhibitors
• Fragment-Based Drug Discovery
• +۴ مورد دیگر

Dr. Hacer Karatas Bristow is an Assistant Professor in the Department of Chemistry at West Virginia University (WVU), where she leads the Karatas Lab. She holds a Ph.D. in Medicinal Chemistry from the University of Michigan and completed postdoctoral research at EPFL (Switzerland) and the Max Planck Institute (Germany). Her research focuses on developing protein-protein interaction inhibitors and fragment-based drug discovery to address unmet needs in cancer treatment. Key targets include Hox/Pbx transcription factors, β-catenin/BCL9 interactions, and cardiac troponin C for heart failure therapies. Her academic journey includes prior faculty positions at Istanbul Medipol University (Turkiye) before joining WVU in 2022. She teaches Medicinal Chemistry and oversees a dynamic lab team comprising graduate and undergraduate students. Recent lab milestones include candidacy exams passed by Abra Dadum, Pegah Norouzi, and Vahid Lotfikahalaji in 2024. Research interests span drug discovery, assay development, and mechanism-of-action studies for small molecules and peptidomimetics. The lab actively recruits students through WVU’s RAP, SURE, and CHEM 497 programs. Collaborative projects include cardiac contractility modulation via calcium sensitization and transcription factor inhibition strategies for oncology.

Jean-Marie Lehnمشاهده پروفایل

استاد

• Supramolecular Chemistry
• Molecular Recognition
• Dynamic Combinatorial Chemistry
• +۳ مورد دیگر

Jean-Marie Lehn is a renowned chemist and Nobel Laureate in Chemistry (1987) for his contributions to supramolecular chemistry. He held the Chair of 'Chimie des Interactions Moléculaires' at the Collège de France since 1979 and was a Professor at the University of Strasbourg (1970–1979). His work spans molecular recognition, self-organization, and dynamic combinatorial chemistry. Education: Bachelor of Sciences (1960), University of Strasbourg Ph.D. in Chemistry (1963), University of Strasbourg Postdoctoral research at Harvard University (1964) with Robert Burns Woodward Research Interests: Supramolecular Chemistry: Designing systems that self-assemble via molecular recognition Dynamic Combinatorial Chemistry: Exploring reversible libraries for drug discovery Nanotechnology: Developing programmable materials and adaptive systems Bio-inspired Systems: Mimicking biological processes like ion transport and neural signaling Awards & Honors: Nobel Prize in Chemistry (1987) Gold Medal of the CNRS (1981) Commandeur de l’Ordre de la Légion d’Honneur (1996) Over 30 honorary doctorates worldwide Labs & Teams: Laboratoire de Chimie Supramoléculaire at ISIS, Strasbourg Laboratoire de Chimie des Interactions Moléculaires at Collège de France Adjunct Professorships at institutions like Karlsruhe Institute of Technology

• Proteomics
• Biotechnology
• Cell Culture Technology
• +۴ مورد دیگر

Dr. Raimund Hoffrogge is a Researcher at the University of Bielefeld, affiliated with the Faculty of Engineering. He serves in multiple capacities including as Library Officer for Biotechnology, member of the Examination Board for Molecular Biotechnology (Master), and as personal deputy for Florian Schröder on the Faculty Conference for Academic Staff. His work is centered at the intersection of biotechnology and proteomics, with particular focus on Chinese hamster ovary (CHO) cell systems for biopharmaceutical production. Dr. Hoffrogge's research primarily focuses on proteomic analysis of biotechnological systems, with special emphasis on CHO cells used in therapeutic protein production. His work spans multiple areas including rAAV (recombinant adeno-associated virus) production, DNA methylation in CHO cells, extracellular vesicle analysis, and cell culture optimization techniques. He has developed expertise in advanced proteomic methodologies including SILAC-MS, phosphoproteomics, and label-free protein quantification approaches. Analysis of his recent publications (2016-2025) reveals a consistent research trajectory centered on understanding and optimizing cellular systems for biopharmaceutical production. His work shows increasing sophistication in multi-omics integration, with recent papers combining proteomic, genomic, and epigenetic analyses. The research demonstrates practical applications in improving yields of therapeutic proteins and viral vectors, with particular attention to cellular response mechanisms under various culture conditions. Dr. Hoffrogge collaborates extensively within the University of Bielefeld's Center for Biotechnology (CeBiTec) and works closely with the Cell Culture Technology Group and Systems Biotechnology Group. His laboratory work focuses on developing and applying advanced proteomic techniques to solve practical challenges in bioproduction systems.

Liangcai Guمشاهده پروفایل

دانشیار

• Protein Engineering
• Molecular Biology
• Biochemistry
• +۱۱ مورد دیگر

Liangcai Gu is an Associate Professor in the Department of Biochemistry at the University of Washington, with an adjunct appointment in Genome Sciences. His research focuses on developing protein-based sensors and actuators for chemogenetic and optogenetic manipulation of cellular behaviors in vivo, alongside spatial barcoding and sequencing technologies for single-cell transcriptomics and proteomics in intact tissues. Education B.S., Lanzhou University (1998) M.S., Tsinghua University (2002) Ph.D., University of Michigan (2008) Research Themes Gu's work bridges molecular engineering and systems biology, with applications in cellular senescence, chronic pain, addiction, and therapeutic evolution. His lab combines protein design, spatial omics, and multimodal control systems to address disease mechanisms and biotechnological challenges. Scientific Awards Cutting-Edge Basic Research Award (CEBRA), 2020 Safeway Early Career Award in Cancer Research, 2018 University of Washington Innovation Award, 2017 Jane Coffin Childs Postdoctoral Fellowship, 2009–2012 Young Investigator Award, Society for Industrial Microbiology, 2009 Robert M. Scarborough Award for Graduate Excellence, American Chemical Society, 2008

Stefan M. Kastمشاهده پروفایل

استاد

• Computational Chemistry
• Molecular Dynamics Simulations
• Solvation Theory
• +۵ مورد دیگر

Professor Stefan M. Kast is a faculty member in the Department of Physical Chemistry at the Faculty of Chemistry and Chemical Biology, TU Dortmund University. His research focuses on computational chemistry, molecular dynamics simulations, and solvation theory, with particular emphasis on integral equation theory and biophysical applications including potassium channel studies. Professor Kast's research interests span computational chemistry, molecular dynamics simulations, and solvation theory, with particular emphasis on integral equation theory. His work bridges physical chemistry and biophysics, investigating molecular systems in aqueous environments, protein structure and function, and chemical shift predictions. His interdisciplinary approach combines theoretical methods with experimental validation, focusing on the molecular mechanisms underlying biological processes. Professor Kast leads an active research group with numerous PhD students and postdoctoral researchers. His group participates in major collaborative research efforts including the RESOLV Excellence Cluster. His work has significant implications for understanding molecular interactions in aqueous environments, with applications in drug design and biomolecular engineering. Professor Kast maintains laboratory facilities within the Physical Chemistry department at TU Dortmund University, where his team conducts computational research supported by high-performance computing resources. His group collaborates extensively with experimental researchers to validate theoretical predictions and develop new computational approaches for complex biomolecular systems.

Anja Sandströmمشاهده پروفایل

استاد

• Medicinal Chemistry
• Peptidomimetics
• Drug Discovery
• +۳ مورد دیگر

Anja Sandström is a Professor at the Department of Medicinal Chemistry; Drug Design and Discovery, Uppsala University, with a focus on peptides and peptidomimetics in drug discovery for infectious diseases. She serves as Deputy Dean of Education at the Faculty of Pharmacy and has held leadership roles including Study Director and Assistant Head of Department. Her research spans Antiviral protease inhibitors (SARS-CoV-2, hepatitis C, Zika, tick-borne encephalitis) Antibacterial agents targeting LpxH and signal peptidase Peptidomimetic analgesics for neuropathic pain Chemical methodologies in solid-phase peptide synthesis Structure-activity relationships in drug design Computational and experimental screening techniques Recent publication trends highlight her work on Broad-spectrum antivirals against coronaviruses and flaviviruses Novel scaffolds for protease inhibition Metabolic stability and permeability of peptide-based drugs Advanced synthetic methods via palladium catalysis Modulation of substance P fragments for pain relief Targeting bacterial enzymes for antibiotic development Scientific accolades include multiple teaching awards from Uppsala University and the Pharmaceutical Student Union, with recognition as an excellent teacher in 2017. She has contributed to 15+ peer-reviewed articles in journals like Antimicrobial Agents and Chemotherapy , Journal of the American Chemical Society , and European Journal of Medicinal Chemistry , covering antivirals, antibiotics, and neuropharmacological agents. Her laboratory collaborates on multidisciplinary projects integrating Organic synthesis Biochemical assays Computational modeling Pharmacokinetic studies Structure-based drug design Translational research in pain and infectious diseases

• Medicinal Chemistry
• Drug Discovery
• Pharmacology
• +۳ مورد دیگر

Kristian Sandberg is a researcher at the Department of Medicinal Chemistry, Preparative Medicinal Chemistry , affiliated with the Faculty of Pharmacy at Uppsala University and the Science for Life Laboratory (SciLifeLab) . His work focuses on drug discovery and development, particularly targeting viral proteases and inflammatory diseases. Research Interests : Drug discovery using DNA-encoded chemical libraries Computational methods for antiviral drug design Proteomics in inflammatory bowel disease Metabolism in immune response pathways Academic-industry collaborations in drug development Publication Trends : His recent research emphasizes antiviral therapies, particularly against coronaviruses, and proteomic studies in immunology. Earlier work includes aptamer-based modulation of receptors and metabolic regulation in immune cells. Affiliations : Uppsala University SciLifeLab Karolinska Institutet (previous collaboration)

Stuart J. Conwayمشاهده پروفایل

استاد

• Chemical Biology
• Medicinal Chemistry
• Epigenetics
• +۳ مورد دیگر

Stuart J. Conway is the inaugural Michael and Alice Jung Endowed Chair in Medicinal Chemistry and Drug Discovery at the University of California, Los Angeles (UCLA). He has held faculty positions at the University of St Andrews and the University of Oxford, where he was E. P. Abraham Cephalosporin Fellow at St Hugh’s College. He is also an Associate Editor for Journal of Medicinal Chemistry and ACS Bio & Med Chem Au , and served as President of the Royal Society of Chemistry Organic Division from 2019–2022. Education: BSc in Chemistry with Medicinal Chemistry, University of Warwick (1994–1997) PhD in Pharmacology, University of Bristol (1997–2000) Postdoctoral Research, University of Cambridge (2000–2003) Research Interests: Conway's research lies at the intersection of chemistry and biology, using synthetic organic chemistry to develop molecular probes for studying biological systems. His work is organized into three main themes: Human Epigenetics: Investigating epigenetic processes in health and disease, particularly targeting bromodomain-containing proteins like BRD4 and CREBBP for cancer therapy. Cellular Redox: Designing bio-responsive chemistries to measure and manipulate redox conditions in cells, with applications in cancer imaging and prodrug activation. Parasite Epigenetics: Exploring epigenetic regulation in parasites such as Trypanosoma , Leishmania , and Schistosoma to identify novel therapeutic targets for neglected tropical diseases. Publication Trends: Conway's recent publications demonstrate a strong focus on bromodomain inhibitors, hypoxia-activated prodrugs, and parasite-targeted therapies. His work integrates chemical biology, structural biology, and translational medicine, with applications in cancer and infectious disease treatment. Notable contributions include the development of selective ligands for CREBBP and parasite bromodomains, as well as innovative imaging tools for hypoxia and redox states. Scientific Awards: Translational Melanoma Research Alliance Team Science Award (2024) UCB-Ehrlich Award for Excellence in Medicinal Chemistry (2024) Robert M. Scarborough Award (2024) Karle Lecturer, University of Michigan (2021) RSC BMCS Lectureship (2016) Fellow of the Royal Society of Chemistry (2014) EFMC Prize for a Young Medicinal Chemist in Academia (2012) Advising & Grants: Conway has supervised numerous PhD students and postdoctoral researchers across his labs at UCLA, Oxford, and St Andrews. His research has been supported by major funding bodies including the Royal Society, Wellcome Trust, Cancer Research UK, and the European Research Council. He is actively involved in mentoring early-career scientists and promoting diversity in postgraduate education. Labs & Teams: At UCLA, the Conway Group operates across multiple lab spaces in Young Hall (5033, 5036, 5076, 5077, 5085, 5086, 5090, 5096) and offices (5070/5070A). The group collaborates extensively with structural biologists, parasitologists, and translational researchers both within UCLA and internationally.

Jeff Martellمشاهده پروفایل

استادیار

• Catalysis
• Biochemistry
• Organic Chemistry
• +۴ مورد دیگر

Jeff Martell is an Assistant Professor in the Department of Chemistry at the University of Wisconsin-Madison. His research merges synthetic and biological catalysis, focusing on enzyme-mimicking catalysts within evolvable three-dimensional scaffolds. Education: B.A., 2009, Northwestern University Ph.D., 2015, Massachusetts Institute of Technology Postdoctoral Researcher, 2015–2019, University of California, Berkeley Research interests include developing synthetic catalysts that replicate enzyme efficiency and selectivity through cage-like architectures, combinatorial strategies, and high-throughput screening. Applications span synthetic methodology, energy, environmental remediation, diagnostics, targeted therapeutics, and chemical separations. Recent publications highlight advancements in DNA-scaffolded catalysis, proximity labeling, and polymer-degrading enzyme engineering. Key grants include a three-year Army Research Office award for porous protein frameworks and Hartwell Foundation support for biomedical research. Scientific Awards: Hartwell Foundation Individual Biomedical Research Award Army Research Office Grant Current and former students include Ashley Ogorek (ACS Young Investigator Award), Xu (Assistant Professor, Nanjing University), and NSF Graduate Research Fellowship recipients David Hardy and Max Unger. The Martell Group emphasizes interdisciplinary collaboration and innovative catalytic mechanisms.