Raimund Hoffrogge

Dr. Raimund Hoffrogge is a Researcher at the University of Bielefeld, affiliated with the Faculty of Engineering. He serves in multiple capacities including as Library Officer for Biotechnology, member of the Examination Board for Molecular Biotechnology (Master), and as personal deputy for Florian Schröder on the Faculty Conference for Academic Staff. His work is centered at the intersection of biotechnology and proteomics, with particular focus on Chinese hamster ovary (CHO) cell systems for biopharmaceutical production.

Dr. Hoffrogge's research primarily focuses on proteomic analysis of biotechnological systems, with special emphasis on CHO cells used in therapeutic protein production. His work spans multiple areas including rAAV (recombinant adeno-associated virus) production, DNA methylation in CHO cells, extracellular vesicle analysis, and cell culture optimization techniques. He has developed expertise in advanced proteomic methodologies including SILAC-MS, phosphoproteomics, and label-free protein quantification approaches.

Analysis of his recent publications (2016-2025) reveals a consistent research trajectory centered on understanding and optimizing cellular systems for biopharmaceutical production. His work shows increasing sophistication in multi-omics integration, with recent papers combining proteomic, genomic, and epigenetic analyses. The research demonstrates practical applications in improving yields of therapeutic proteins and viral vectors, with particular attention to cellular response mechanisms under various culture conditions.

Dr. Hoffrogge collaborates extensively within the University of Bielefeld's Center for Biotechnology (CeBiTec) and works closely with the Cell Culture Technology Group and Systems Biotechnology Group. His laboratory work focuses on developing and applying advanced proteomic techniques to solve practical challenges in bioproduction systems.