Wei-Shou Hu

Wei-Shou Hu is a Professor in the Department of Chemical Engineering and Materials Science at the University of Minnesota, affiliated with the Institute for Engineering in Medicine and the Cellular Mechanisms of Cancer initiative. His research bridges chemical engineering principles with biomedical applications, focusing on synthetic biology, biopharmaceutical manufacturing, and viral vector production.

• Develops synthetic cell lines for recombinant adeno-associated virus (rAAV) production
• Investigates metabolic robustness in fed-batch cell culture systems
• Applies multi-omics approaches (transcriptomics, proteomics) to bioprocess optimization
• Contributes to biomanufacturing standards through collaborations with NIIMBL and NIST

Key research areas include:

• Synthetic Biology: Designing engineered mammalian cell systems and CHO lines for therapeutic applications
• Metabolic Engineering: Enhancing cellular metabolism for improved biopharmaceutical yields
• Viral Vector Production: Optimization of AAV production systems for gene therapy
• Genomic Analysis: Developing algorithms for sequencing data interpretation and integration

Recent publications show expertise in:

• Comparative transcriptomic/proteomic analysis of viral production systems
• Systematic characterization of synthetic cell line productivity
• Elucidation of capsid assembly mechanisms in viral vectors
• Development of mechanistic-empirical models for bioprocess control

Dr. Hu has received multiple research grants including:

• National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) membership
• NIH/NIGMS funded projects on biotechnology development
• Collaborative grants with University of Massachusetts Lowell on biomanufacturing

His work contributes to UN Sustainable Development Goals through advancements in biopharmaceutical manufacturing and disease treatment technologies.