Gyun Min Lee

Professor Gyun Min Lee is a faculty member in the Department of Biological Sciences at Korea Advanced Institute of Science and Technology (KAIST), where he leads the Animal Cell Engineering Lab. His research focuses on developing advanced mammalian cell systems for therapeutic protein and viral vector production through innovative engineering approaches.

Dr. Lee earned his Ph.D. in Chemical Engineering from the University of Michigan, providing him with a strong foundation at the intersection of engineering principles and biological systems. His technical expertise spans from molecular biology to bioprocess engineering, enabling comprehensive solutions for biopharmaceutical production challenges.

Professor Lee's research program centers on animal cell engineering for biopharmaceutical applications. His team utilizes synthetic biology approaches including artificial promoters and transcriptional regulation to develop improved mammalian cell lines. A major focus involves using CRISPR/Cas9 technology and site-specific gene integration to construct cell libraries for discovering novel engineering targets. Additional research areas include cell line development platforms, bioprocess optimization, apoptosis and autophagy studies in production cell lines, proteomic analysis of host cell proteins, and strategies for improving difficult-to-express protein production.

Analysis of Professor Lee's recent publication record reveals a strong emphasis on genome editing technologies for cell line improvement, particularly using CRISPR-based screening methods in CHO and HEK293 cells. His work bridges fundamental molecular mechanisms with practical bioprocess applications, demonstrating consistent innovation in enhancing productivity while maintaining product quality in therapeutic protein manufacturing. The research shows increasing sophistication in systems-level approaches to cell engineering.

Professor Lee actively mentors researchers in the Animal Cell Engineering Lab, guiding projects that address critical challenges in biopharmaceutical production. His research is supported by various funding sources focused on advancing cell engineering technologies for therapeutic applications.

The Animal Cell Engineering Lab maintains state-of-the-art facilities for mammalian cell culture, genetic engineering, and bioprocess development. The lab collaborates extensively with both academic and industry partners to translate basic research findings into practical applications for the biopharmaceutical industry, contributing significantly to advancements in therapeutic protein and viral vector manufacturing.