Jae Seong Lee

Dr. Jae Seong Lee serves as Associate Professor in the Department of Molecular Science and Technology at Ajou University, South Korea, where he directs the Mammalian Cell Designers' Lab. His research bridges mammalian synthetic biology and industrial biopharmaceutical production through advanced cell engineering.

Academic credentials include B.S. and Ph.D. in Biological Sciences from KAIST, followed by postdoctoral training at the Novo Nordisk Foundation Center for Biosustainability (DTU). His educational journey established foundations in genetic and metabolic engineering of CHO cells.

Research focuses on reprogramming mammalian cells using genome-scale methodologies for:

• Therapeutic protein production
• Diagnostic applications
• Drug discovery platforms
• Big data-driven cell line optimization
• CRISPR-based genome editing technologies

These efforts target cost reduction in biopharmaceutical manufacturing while enhancing Korean industry competitiveness.

Recent publications demonstrate CRISPR screening breakthroughs in CHO cells and inducible expression systems, establishing foundational technologies for next-generation bioproduction. Work consistently appears in high-impact journals like Metabolic Engineering and Scientific Data.

Mentorship spans 14+ graduate students, with multiple recipients of KSBB and KSIEC Excellent Poster Awards. Lab activities include frequent invited talks at national symposia and international conferences across Korea and Europe.

The Mammalian Cell Designers' Lab operates from Paldal Hall at Ajou University, maintaining active collaborations with biopharma industry partners to translate synthetic biology innovations into commercial production pipelines.