جست‌وجوی استاد و پژوهشگر

Sonam Parakhمشاهده پروفایل

پژوهشگر ارشد

• Amyotrophic Lateral Sclerosis (ALS)
• Frontotemporal Dementia with Motor Neuron Disease
• Molecular Origins of Neurodegenerative Diseases
• +۴ مورد دیگر

Sonam Parakh is a Research Fellow at the Motor Neuron Disease Research Centre within Macquarie Medical School , Macquarie University , where she has worked since 2017. Her research focuses on elucidating the molecular origins of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) , with a particular emphasis on endoplasmic reticulum stress, protein misfolding, and therapeutic target development. Education: PhD in Neuroscience (2016, Macquarie University) MSc in Biotechnology and Bioinformatics (2012, La Trobe University) BSc in Biotechnology (2009, Bangalore University) Her research explores TDP-43 pathology , C9orf72 dipeptide repeats , and ER-Golgi trafficking in ALS/FTD. Recent projects include: MNDRA Innovator : Targeting TDP-43 with nucleoredoxin (NRX) gene therapy (2023-2024) MND 24 : Investigating GABAA agonists against TDP-43 pathology (2025-2026) Her publications highlight roles for protein disulfide isomerases , redox activity , and cyclin F mutations in neurodegenerative disease mechanisms. Current collaborations involve researchers like J. Atkin , V. Gupta , and C. Blair , with affiliations to Macquarie University’s centralized biobank project (2015-2019) and the Centre for Motor Neuron Disease Research (2017-2019).

• Healthcare Informatics
• Neurodegenerative Diseases
• Patient Safety
• +۶ مورد دیگر

Julie Li is a Researcher in the Centre for Health Systems and Safety Research at Macquarie University's Faculty of Medicine, Health and Human Sciences. She holds a Doctor of Philosophy and focuses on healthcare informatics, patient safety, and neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). Her research explores DNA repair mechanisms, protein misfolding, and ER-Golgi trafficking dysregulation in neurodegenerative disorders. With an h-index of 13 and over 944 citations, her work bridges clinical and molecular insights, emphasizing translational applications in healthcare technology and safety. Her research interests include understanding the molecular pathways underlying ALS pathology, particularly the role of TDP-43, C9orf72 mutations, and cyclin F defects. She has contributed to studies on ER stress, Golgi fragmentation, and the protective roles of proteins like PDI and ERp57. Julie has also explored healthcare information systems, advocating for safer patient care through technological interventions. Education: Doctor of Philosophy (PhD) Key achievements include awards such as the Australian Institute of Health Innovation Three Minute Thesis (2024), Best Poster at the Context Sensitive Health Informatics Conference (2023), and the Branko Cesnick Award (2024). Her work has been published in high-impact journals, with a focus on interdisciplinary approaches to neurodegenerative disease mechanisms and healthcare innovation. Julie collaborates internationally on projects addressing ER-Golgi trafficking defects in ALS and FTD. Her lab’s work on real-time clinical dashboards and mobile point-of-care testing (PoCT) aims to enhance diagnostic efficiency in healthcare settings.

Heike Lamanمشاهده پروفایل

استاد

• Ubiquitin ligases
• Cell cycle regulation
• Cancer biology
• +۵ مورد دیگر

Professor Heike Laman is the Head of the Department of Pathology and Professor of Cellular and Molecular Biology at the University of Cambridge , leading research on ubiquitin ligases and their roles in disease. Her work bridges molecular mechanisms to therapeutic applications, focusing on cancer, neurodegeneration, and protein homeostasis. Current affiliation: Department of Pathology, School of the Biological Sciences Resident at Clare College since 2014 (Fellow and Graduate Admissions Tutor) Research Interests: Ubiquitin ligases orchestrate diverse cellular signals beyond protein degradation, influencing activity, localization, and interactions. Key areas include: Cancer: Investigating SCF-Fbxw7 networks in epithelial cancers and cyclin E1 accumulation Neurodegeneration: Fbxo7's role in Parkinson's disease and dopaminergic neuron survival Therapeutic Innovation: Developing PROTACs and nanobodies to target ubiquitin ligases Publication Trends: Recent work spans ubiquitin signaling in cancer metabolism, neuroprotective pathways in Parkinson's, and structure-based design of degraders. Collaborations with AstraZeneca and academic experts highlight translational focus. Scientific Awards: Recognized for academic leadership, including election to Clare College Fellowship (2014) and early career Imperial Cancer Research Fund Fellowship. Advising: Mentors PhD students in projects on ubiquitin ligases, Parkinson's, cancer metabolism, and targeted protein degradation, with lab members working in 3D organoids , mouse models , and hiPSC-derived systems . Labs & Teams: Based at the Department of Pathology (Downing Site, Cambridge), the lab collaborates across Genetics , Pharmacology , and Clinical Neurosciences , with access to the Microscopy Bioscience Platform and Cambridge Stem Cell Institute .

Henry F. Frierson, Jr.مشاهده پروفایل

استاد

• Pathology
• Cytopathology
• Prostate Cancer Research
• +۴ مورد دیگر

Henry F. Frierson, Jr., M.D. is a Professor of Pathology and Director of Cytopathology at the University of Virginia School of Medicine. With decades of experience in academic pathology, Dr. Frierson has established himself as a leading expert in cytopathology and prostate cancer research. Dr. Frierson received his B.S. from Davidson College in 1977 and his M.D. from the Medical University of South Carolina in 1981. He completed his residency in Anatomic and Clinical Pathology at the University of Virginia from 1981-1985. His educational background provided the foundation for his subsequent specialization in cytopathology and molecular cancer research. Dr. Frierson's research primarily focuses on mouse models of prostate cancer, where he has characterized the phenotypes of numerous genotypes with genetic alterations involving PTEN, MYC, TGFBR2, SMAD2, APC, and AKT. His work bridges basic science with clinical applications, particularly in understanding cancer progression mechanisms. He has also conducted international volunteer pathology services in St. Lucia, Peru, Belize, and Nicaragua, demonstrating commitment to global health initiatives. His publication record spans nearly four decades, with recent work emphasizing molecular mechanisms in adenoid cystic carcinoma and prostate cancer. The research shows a clear trajectory from diagnostic pathology toward molecular oncology, with increasing focus on genetic alterations and their clinical implications. His 2022 publication on MYB and MYBL1 rearrangements represents the current direction of his work in cancer genomics. Dr. Frierson maintains active clinical service in both Cytopathology and Surgical Pathology at UVA Health. His work demonstrates how academic pathology integrates diagnostic expertise with cutting-edge research to advance cancer understanding and treatment.

Carol Auمشاهده پروفایل

پژوهشگر

• Neurodegenerative Diseases
• Molecular Biology
• Cell Culture Models
• +۳ مورد دیگر

Dr. Carol Au is a Researcher at the Dementia Research Centre, Macquarie University. She holds a PhD in Medicine from the University of Sydney (Children’s Hospital at Westmead) and completed postdoctoral training at the University of California San Diego (UCSD) under an American Heart Association Fellowship. Prior to her current role, she worked at the Children’s Cancer Institute, Institute for Molecular Biosciences, and UNSW Sydney, joining the Dementia Research Unit at UNSW in 2017 before moving to Macquarie University in 2018. Education: PhD in Medicine, University of Sydney (Children’s Hospital at Westmead) Postdoctoral Fellowship at UCSD (American Heart Association) Her research focuses on using tissue culture models and AAV technology to study molecular mechanisms of neurodegenerative diseases such as Motor Neuron Disease, Frontotemporal Dementia, and Alzheimer’s. Recent work emphasizes protein pathology in ALS/FTD and tau-related mechanisms. Collaborations span international institutions, with publications in journals like Neuron and Cells . Awards: American Heart Association Fellowship Labs/Teams: Active in the Dementia Research Centre, collaborating on projects involving AAV-based therapies and neurodegenerative disease modeling.

• Cancer Biology
• Hematopoietic Malignancies
• Extracellular Vesicles
• +۶ مورد دیگر

Margaret McGee is an Associate Professor at the School of Biomolecular and Biomedical Science , University College Dublin , with a research focus on cancer biology and extracellular vesicle signaling. Her work spans hematological malignancies, bone marrow microenvironment interactions, and mitotic regulatory mechanisms. She coordinates major modules including Genetic Basis of Disease and Regulation of Gene Expression . BSc University of Reading Dip Applied Science Dublin Institute of Technology PhD Biochemistry Trinity College Dublin Her research explores extracellular vesicle-mediated communication in cancer progression, cyclophilin A's role in mitotic exit, and preclinical biotherapeutic development. Current collaborations with Vejle Hospital Denmark and Mater Hospital Dublin investigate EV-based liquid biopsies for therapy response prediction. Notably, she co-authored the foundational MISEV2023 guidelines for extracellular vesicle research. Scientific contributions include: Wellcome Trust ISSF Mid Career Fellow (2017) Conway Institute Fellow (2007) IRCSET Fellowship (2003) She leads the EU Twinflag consortium for EV-based biomarker development in joint disorders and chairs the SBBS Research, Innovation and Impact Committee (2020-2024). Her lab has trained numerous researchers who now hold prominent positions in academia and industry.

Jennilee Davidsonمشاهده پروفایل

پژوهشگر ارشد

• Cellular biology
• Protein degradation
• Neurobiology
• +۵ مورد دیگر

Jennilee Davidson is a Research Fellow at Macquarie University's Motor Neuron Disease Research Centre, affiliated with the Macquarie Medical School. Her research focuses on cellular biology, protein degradation, and neurodegenerative diseases. She holds a PhD in Biomedical Sciences from York University and has prior roles in clinical research and industry, including Medical Sales Representative at Boehringer Ingelheim. Education: Bachelor of Science (Honours in Biology), Queen's University Kingston Master of Science (Molecular and Cellular Biology), York University Graduate Diploma (Neuroscience), York University Doctor of Philosophy (Biomedical Sciences), York University Her research interests span cellular health mechanisms, proteomics, and neurobiology, with a focus on ALS/FTD pathogenesis. Key areas include protein degradation pathways, TDP-43 interactome analysis, and cyclin F's role in neurodegeneration. She has led projects like 'Developing a self-regulating TDP-43 degrader therapeutic for ALS' and 'Characterising the interactome of sequestosome-1/p62.' Her publications explore topics such as fractal-based neurosurgery, cyclin F's impact on TDP-43 turnover, and proteomic profiling of neurodegenerative diseases. Collaborations span institutions globally, emphasizing translational research in ALS/FTD and protein homeostasis.

Albert Leeمشاهده پروفایل

دانشیار

• Neuroproteomics
• Cellular Survival Mechanisms
• Proteostasis Dysfunction
• +۳ مورد دیگر

Albert Lee is an Associate Professor at Macquarie University's Macquarie Medical School and leads the Neuroproteomics Research Group within the Motor Neuron Disease Research Centre. His career spans academic research and education, with a focus on understanding cellular survival mechanisms in neurodegenerative diseases like ALS and FTD. He holds a PhD from Macquarie University and completed postdoctoral training at Johns Hopkins University and New York University. Education: B.Sc. Molecular Biotechnology (2004, University of Sydney) M.Biotech(Hons I)/Business (2006, Macquarie University) Ph.D. in Proteomics (2011, Macquarie University) Research Interests: Dr. Lee's work integrates proteomics to study post-translational modifications (e.g., ubiquitination, phosphorylation) and their roles in neurodegeneration. His lab focuses on TDP-43 pathobiology, SCF Cyclin F dysfunction in ALS/FTD, and translational proteomics for disease biomarkers. Collaborative projects include NHMRC Dementia Teams Grants and industry partnerships. Articles Trends: Recent studies highlight TDP-43 aggregation mechanisms, mitochondrial dysfunction in Machado Joseph disease, and therapeutic strategies targeting autophagy. His proteomic approaches uncover novel pathways linking ubiquitin ligase defects to neurodegeneration. Awards: 2020 HDR Supervisor Award (Macquarie University) 2021 Faculty Teaching Excellence Award NHLBI Postdoctoral Fellowship (2011–2013) Advising & Grants: Supervised 19 students across PhD/MRes programs and leads 37 active projects, including NHMRC-funded initiatives and industry grants. His Neuroproteomics group employs 3 postdocs and 2 research assistants. Labs & Teams: Heads the Neuroproteomics Research Group, collaborating with the Australian Proteome Analysis Facility (APAF) and the Macquarie Centre for MND Research. Active in interdisciplinary teams targeting ALS/FTD biomarkers and therapeutics.

• Cancer Research
• Cell Metabolism
• Tumor Biology
• +۲ مورد دیگر

Dr Ruhi Deshmukh is an Honorary Research Fellow at the School of Cancer Sciences, CRUK Scotland Institute. Her research focuses on cancer metabolism, tumor biology, and molecular mechanisms driving metastasis and tumorigenesis. Her work spans diverse areas including: Metabolic reprogramming in cancer progression Role of extracellular vesicles in invasive microenvironments Epigenetic regulation of tumor suppression Physiological cell culture modeling Recent peer-reviewed articles highlight her contributions to understanding: Glioma metabolism and IDH1 signaling Lung adenocarcinoma initiation and therapeutic vulnerabilities Lipid metabolism in breast cancer metastasis Stem cell metabolic regulation Her interdisciplinary research bridges cancer biology, biochemistry, and cellular metabolism.

• Neurodegenerative Diseases
• Stem Cell Modeling
• Alzheimer's Disease Research
• +۲ مورد دیگر

Dr. Simon Maksour serves as the Race Against Dementia – Dementia Australia Research Foundation Research Fellow (2025-2030) within the School of Medical Sciences at the University of Sydney's Faculty of Medicine and Health. His research bridges molecular neuroscience and therapeutic development for neurodegenerative disorders. Dr. Maksour's research focuses on modeling neurodegenerative diseases using induced pluripotent stem cells (iPSCs) to generate neural cells and organoids. His work spans Alzheimer's disease , Motor Neuron Disease , Friedreich's ataxia , Vanishing White Matter disease , Huntington's disease , and Parkinson's disease . Current projects target microglia-specific therapies for Alzheimer's disease, including gene therapy validation in advanced stem cell models and microglial cell replacement strategies. His publication record demonstrates consistent output in high-impact journals, with recent first-author papers in BMC Biology (2025), Frontiers in Cellular Neuroscience (2024), and Antioxidants & Redox Signaling (2024). Research themes include: Neurosciences and Mental Health Healthy Ageing Cellular/Molecular mechanisms of neurodegeneration Therapeutic interventions for dementia Dr. Maksour received the Australasian Society for Stem Cell Research (ASSCR) Rising Star Award for his contributions to stem cell modeling of neurodegenerative conditions. His work has been featured in media outlets including 2GB Sydney and UOW communications. As an active supervisor, he offers PhD and honours projects in microglia-targeted Alzheimer's therapies, microglial replacement strategies, and neuroprotective compound screening using brain organoids. His Race Against Dementia Fellowship provides dedicated funding through 2030 for developing novel therapeutic approaches.

Marco Morschمشاهده پروفایل

دانشیار

• Neurodegeneration
• Zebrafish Models
• Protein Aggregation
• +۳ مورد دیگر

Marco Morsch is an Associate Professor and Co-Director of Research at the Macquarie Medical School, Macquarie University. He leads a neurodegeneration research group focusing on motor neuron diseases (MND/ALS) using zebrafish models. He holds a PhD from the University of Bonn and completed a postdoc at the University of Sydney before joining Macquarie in 2014. Education: PhD (University of Bonn), Postdoc (University of Sydney) Affiliations: Macquarie Medical School, Motor Neuron Disease Research Centre Roles: Group Leader, Co-Director of Research His research combines advanced microscopy and molecular tools to study neurodegeneration mechanisms, including TDP-43 phase separation and protein aggregation. He pioneered Australia's first zebrafish platform for real-time CNS imaging, addressing critical gaps in preclinical models. Key achievements include groundbreaking work on TDP-43 biology and methylmercury bioremediation. Awards include the 2018 'Outstanding mid-career researcher' and 2020 Academic Of The Year. Current projects involve developing gene therapies for ALS and investigating TDP-43 condensation mechanisms. His lab offers PhD/Masters opportunities in neuron-glia interactions and MND. Collaborations span international institutions, with active grants from NHMRC and NIH. Media engagement includes public science festivals and outreach on motor neuron disease research.

Yazi Keمشاهده پروفایل

استاد

• Neurodegenerative diseases
• Frontotemporal dementia (FTD)
• Amyotrophic lateral sclerosis (ALS)
• +۷ مورد دیگر

Professor Yazi Ke is the Deputy Director (Research and Operations) of the Dementia Research Centre and holds a Professorship in the Department of Biomedical Sciences, Faculty of Medicine and Health Sciences at Macquarie University. She obtained her PhD in Neuroscience from the University of Sydney (2009) and completed postdoctoral research at the Brain and Mind Research Institute (2010-2013). Previously, she served as a research-only Lecturer and Senior Lecturer at UNSW Sydney, supported by ARC DECRA and NHMRC Career Development Fellowships. Her research focuses on neurodegenerative diseases, particularly frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), with expertise in developing transgenic mouse models and investigating pathogenic mechanisms. Affiliations: Macquarie Medical School, Dementia Research Centre, Faculty of Medicine and Health Sciences Education: PhD in Neuroscience (University of Sydney, 2009) Her research interests include: Developing novel FTD/ALS mouse models using transgenesis and AAV approaches Deciphering pathogenic mutations in neurodegenerative diseases Gene therapy strategies for neurodegenerative disorders Recent projects include: FightMND-funded studies on motor neuron disease mechanisms (2024-2028) Advancing immune-resistant gene therapies for FTD and MND (2024-2027) Development of next-gen gene therapy vectors for epilepsy (2024-2026) Notable awards include the UNSW School of Medical Sciences New Researcher of the Year (2015) and Apte Scholarship for Academic Women (2016). Her work has been cited over 4,759 times, with a focus on tau and TDP-43 pathologies, viral neurobiology, and gene therapy applications.

Antonio Marzioمشاهده پروفایل

استادیار

• Cancer Biology
• Ubiquitin-Proteasome System
• DNA Damage Response
• +۳ مورد دیگر

Antonio Marzio is an Assistant Professor at the Weill Cornell Medical College within the Graduate School of Medical Sciences . His research focuses on the ubiquitin-proteasome system (UPS) and its role in cancer progression, particularly in the DNA damage response (DDR) and antitumor immunity . He is affiliated with the Department of Pathology and Laboratory Medicine , leveraging multidisciplinary approaches like biochemistry, mouse models, and pharmacotherapy to identify molecular drivers of tumorigenesis for therapeutic applications. Education : Bachelor's (2009), Master's (2010) in Genetics and Molecular Biology, and PhD (2014) in Medical Genetics from SAPIENZA University of Rome. Postdoctoral Training : NYU Langone Health (2014-2022) under Michele Pagano. His lab investigates deregulation of E3 ubiquitin ligases (e.g., KEAP1, EMSY) in non-small cell lung cancer (NSCLC) and other malignancies. Key projects include: KEAP1's role in antitumor immunity UPS activity in innate immunity and tumor immunosurveillance EMSY's oncogenic activity in DNA repair and immune evasion Analysis of his publications reveals a focus on ubiquitin ligases , DNA repair , immune regulation , and cancer therapy , with subtopics spanning proteasomal degradation, synthetic lethality, and optogenetic tools. Notable awards include the American-Italian Cancer Foundation Fellowship (2022, 2014-2016), AIRC-Marie Curie Fellowship (2016-2018), and F1000 membership (2016). His research aims to translate molecular insights into therapeutic strategies for cancers like NSCLC and prostate cancer, utilizing biochemical and genetic models to identify vulnerabilities in tumor-immune interactions.

Flora Chengمشاهده پروفایل

پژوهشگر

• Motor Neuron Disease
• Proteomics
• Neurodegenerative Diseases
• +۳ مورد دیگر

Flora Cheng is a Researcher at Macquarie University's Motor Neuron Disease Research Centre within the Faculty of Medicine, Health and Human Sciences. She holds a FightMND Scholarship (2023-2026) and focuses on RNA-protein interactions of TDP-43 in motor neuron disease. Her research bridges neurodegenerative diseases, proteomics, and molecular mechanisms. Education : Bachelor of Science (Biology & Biochemistry), University of New-Caledonia (2014) Masters of Biotechnology and Business, Sydney (2016) Research Interests : Flora's work centers on understanding TDP-43's role in ALS/FTD, proteomic signatures in neurodegeneration, and therapeutic interventions. She explores molecular pathways involving cyclin F, ubiquitin-proteasome systems, and autophagy activation. Recent Trends in Articles : Her publications emphasize proteomic analyses of TDP-43 interactomes, FTO's DNA repair suppression, and autophagy-based therapies. Themes include neurodegeneration mechanisms, protein aggregation, and biomarker discovery. Awards : FightMND Scholarship (2023-2026) Grants & Collaborations : MNDRA PhD Top-Up Scholarship (2024-2027) International collaborations on neurodegenerative disease mechanisms Labs/Teams : Member of the Neuroproteomics Team under Prof. Albert Lee, focusing on ALS/FTD pathogenesis and proteomic profiling.

Rachelle Balezمشاهده پروفایل

پژوهشگر ارشد

• Biochemistry and cell biology
• Cell neurochemistry
• Regenerative medicine
• +۵ مورد دیگر

Rachelle Balez is an Associate Fellow at the School of Chemistry and Molecular Bioscience within the Faculty of Science, Medicine and Health at the University of Wollongong, where she has been conducting research since 2022. Her work bridges molecular biology, neuroscience, and regenerative medicine to investigate the underlying mechanisms of neurodegenerative diseases, with a particular focus on Alzheimer's disease. Her educational background includes: PhD in Biological Sciences from the University of Wollongong (2015-2022) Bachelor's degree in Biological Sciences from the University of Wollongong (2005-2013) Bachelor's degree in Creative Arts from the University of Wollongong (2005-2010) Dr. Balez's research program centers on understanding the molecular and cellular mechanisms of neurodegenerative diseases using human induced pluripotent stem cell (iPSC) models. She has developed expertise in generating various neural cell types including cortical neurons, astrocytes, and basal forebrain cholinergic neurons to study disease processes. Her work spans epigenetic regulation, calcium signaling, lipid metabolism, and cell death pathways in neurodegeneration. She has pioneered techniques for single-cell metabolomic imaging by mass spectrometry and has made significant contributions to understanding REST/CoREST protein function, nitrosative stress, and presenilin mutations in Alzheimer's disease. Her publication record shows a consistent focus on Alzheimer's disease mechanisms with increasing technical sophistication, from molecular analysis through cellular physiology to advanced single-cell resolution techniques. Recent work demonstrates growing integration of computational approaches with experimental neuroscience for longitudinal data analysis. Dr. Balez has received recognition as an alumna of Homeward Bound, a global women in science leadership initiative, reflecting her commitment to promoting diversity in STEMM fields. She has also exhibited her science-art collaborations in the CoLABs Sci-Art Festival (2017) and co-organized Magnified (2018), a science-art exhibition. She has secured research funding including an Early Mid Career Researcher Enabling Grant (2023) and is currently leading the project 'Sparking and fading: Spatially linking the complex metabolic activities of neurotransmitters and lipids during cell death' (2023-2024), which combines single-cell metabolomic imaging with human iPSC-derived brain cell subtypes to visualize metabolic signatures of cell death.