معرفی
Sonam Parakh is a Research Fellow at the Motor Neuron Disease Research Centre within Macquarie Medical School, Macquarie University, where she has worked since 2017. Her research focuses on elucidating the molecular origins of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD), with a particular emphasis on endoplasmic reticulum stress, protein misfolding, and therapeutic target development.
- Education:
- PhD in Neuroscience (2016, Macquarie University)
- MSc in Biotechnology and Bioinformatics (2012, La Trobe University)
- BSc in Biotechnology (2009, Bangalore University)
Her research explores TDP-43 pathology, C9orf72 dipeptide repeats, and ER-Golgi trafficking in ALS/FTD. Recent projects include:
- MNDRA Innovator: Targeting TDP-43 with nucleoredoxin (NRX) gene therapy (2023-2024)
- MND 24: Investigating GABAA agonists against TDP-43 pathology (2025-2026)
Her publications highlight roles for protein disulfide isomerases, redox activity, and cyclin F mutations in neurodegenerative disease mechanisms.
Current collaborations involve researchers like J. Atkin, V. Gupta, and C. Blair, with affiliations to Macquarie University’s centralized biobank project (2015-2019) and the Centre for Motor Neuron Disease Research (2017-2019).
