معرفی
Alison Hogan is a Research Fellow at the Motor Neuron Disease Research Centre within Macquarie Medical School at Macquarie University. Her research focuses on understanding the molecular mechanisms underlying motor neuron diseases, particularly Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).
Dr. Hogan's research interests span several key areas:
- Amyotrophic Lateral Sclerosis (ALS) and Motor Neuron Disease
- TDP-43 protein pathology and phase separation
- Neurodegeneration mechanisms
- Frontotemporal Dementia (FTD)
- Molecular pathways in motor neuron diseases
Her recent work has focused on the role of TDP-43 protein in neurodegenerative diseases, particularly examining how post-translational modifications affect protein phase separation, compartmentalization, and aggregation. She has developed protocols for characterizing biomolecular condensates through live-cell imaging, contributing significantly to methodologies in the field. Her research bridges molecular biology with clinical neuroscience, aiming to identify therapeutic targets for motor neuron diseases.
Dr. Hogan is currently involved in three major research projects:
- IDEAS 23: TDP-43 nuclear depletion in MND (2024-2027)
- PDF2303: RNA-binding protein SFPQ as therapeutic target (2023-2026)
- MNDRA24: Targeting TDP-43 supplementation in the nucleus (2024-2025)
She serves as a member of the Faculty of Medicine, Health and Human Sciences committee at Macquarie University and has an h-index of 12 with 557 citations according to Scopus data.
