Younbok Lee

Dr. Younbok Lee is a Senior Lecturer in Basic and Clinical Neuroscience at King's College London. He is also Vice President and Head of Discovery at AviadoBio, a university spin-out专注于基因治疗开发 for neurodegenerative disorders. His primary research focuses on gene therapy strategies for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), particularly targeting C9orf72 mutations and RNA-binding proteins like TDP-43. He collaborates closely with institutions like University College London and the Motor Neurone Disease Association.

His work integrates molecular biology, gene therapy vectors, and preclinical studies to address challenges in neurodegenerative disease treatment. Key collaborations include projects with Professors Christopher Shaw and James Uney. Dr. Lee leads multiple funded initiatives, including AAV gene therapy trials and industry partnerships to advance therapies for debilitating neurological conditions.

Notable projects include the development of AVB-101 (a gene therapy targeting frontotemporal dementia) and studies on ER-mitochondria interactions in neurodegeneration. His publications emphasize mechanisms of RNA misprocessing, dipeptide repeat proteins, and cellular stress responses in ALS/FTD progression.