معرفی
Dr. Grant Richter is an early career postdoctoral research fellow at the Centre for MND Research at Macquarie University's Macquarie Medical School. His research focuses on characterizing pathological MND-related proteins within living cells and developing drugs to treat Motor Neuron Disease.
Dr. Richter obtained his PhD from the University of Sydney, where he trained as an electrophysiologist and animal surgeon investigating rodent models of stroke. His dissertation was titled "GABA Drugs for Motor Recovery After Stroke." He also completed master's studies at the Centre for Neuroregeneration at the University of Edinburgh, where he was first exposed to zebrafish models.
Dr. Richter's research spans multiple areas of neuroscience with a particular focus on Motor Neuron Disease. His work combines expertise in electrophysiology, live confocal microscopy of zebrafish motor neurons, and advanced computer image analysis. He has made significant contributions to understanding RNA binding proteins, particularly TDP-43, and their role in neurodegenerative diseases. His earlier work investigated GABAA receptors and Z-drugs pharmacology.
Dr. Richter's publications show a clear progression from his early work on GABAA receptors and stroke recovery to his current focus on MND research, particularly on TDP-43 protein dynamics and biomolecular condensates. His most recent work emphasizes live-cell imaging techniques to characterize protein behavior in living cells.
Dr. Richter is actively involved in multiple research projects at Macquarie University, including:
- MND 24: What's upstream of loss of nuclear TDP-43 function? - The impact of phosphorylation on RNA binding (2025-2026)
- MNDRA24: Probing molecular drivers of TDP-43 phase transition: the influence of lysine modifications (2024-2025)
- Characterising the interactome of sequestosome-1/(p62) – the peacemaker between protein homeostasis and dysfunction (2023)
Dr. Richter works in the Morsch Lab at Macquarie University, where he applies cutting-edge techniques of live confocal microscopy of zebrafish motor neurons and advanced computer image analysis to study Motor Neuron Disease mechanisms.
